{{cs1 config|name-list-style=vanc|display-authors=6}} {{drugbox | drug_name = Protodesnitazene | image = Protodesnitazene_structure.png | image_class = skin-invert-image | legal_UK = | legal_DE = | C = 23 | H = 31 | N = 3 | O = 1 | IUPAC_name = N,N-diethyl-2-[2-[(4-propoxyphenyl)methyl]benzimidazol-1-yl]ethanamine | CAS_number = 805212-21-9 | UNII = 3U89F8KB95 | ChemSpiderID = 129433206 | PubChem = 157010653 | smiles = CCCOC1=CC=C(C=C1)CC2=NC3=CC=CC=C3N2CCN(CC)CC | StdInChI= 1S/C23H31N3O/c1-4-17-27-20-13-11-19(12-14-20)18-23-24-21-9-7-8-10-22(21)26(23)16-15-25(5-2)6-3/h7-14H,4-6,15-18H2,1-3H3 | StdInChIKey = CEHFMRGBRNNSCM-UHFFFAOYSA-N }}
'''Protodesnitazene''' is a benzimidazole derivative which has been sold as a designer drug, and has potent opioid effects. It has been identified in Canada, Australia, the United Kingdom and Finland, first appearing in early 2025.<ref>{{cite web |title=High Risk Substance Detected In Fentanyl Trafficking Investigation |url=https://www.sarniapolice.ca/news/530/high-risk-substance-detected-in-fentanyl-trafficking-investigation/ |website=Sarnia Police Service |date=13 March 2025 |access-date=17 August 2025}}</ref><ref>{{cite web |title=Fredericton Police Warn of New, Potentially Fatal Street Drug |url=https://www.fredericton.ca/your-government/news/fredericton-police-warn-new-potentially-fatal-street-drug |website=City of Fredericton |publisher=Fredericton Police |date=9 April 2025 |access-date=17 August 2025}}</ref><ref>{{cite web |title=New nitazene (strong opioid) Protodesnitazene detected |url=https://www.poisonsinfo.health.qld.gov.au/__data/assets/pdf_file/0033/385854/Queensland-Drug-Warning-new-nitazene-strong-opioid-Protodesnitazene-detected.pdf |website=Queensland Health |publisher=Queensland Government |date=March 2025 |access-date=17 August 2025}}</ref><ref>{{cite web | vauthors = Gwynn L |title=Nitazines found in black market vapes as criminals make new variations to evade detection |url=https://www.abc.net.au/news/2025-04-04/new-nitazene-detected-in-australia-for-first-time/105130890 |website=ABC News |publisher=Australian Broadcasting Corporation |date=4 April 2025 |access-date=17 August 2025}}</ref><ref>{{cite web |title=Rapid Action Drug Alerts and Response (RADAR) Alert: Nitazenes |url=https://publichealthscotland.scot/publications/rapid-action-drug-alerts-and-response-radar-alert-nitazenes/rapid-action-drug-alerts-and-response-radar-alert-nitazenes-version-20/what-are-nitazenes/ |website=Public Health Scotland |publisher=NHS Scotland |date=12 August 2025 |access-date=17 August 2025}}</ref><ref>{{cite web |title=Customs warns about an extremely dangerous substance in the drug trade |url=https://tulli.fi/en/-/customs-warns-about-an-extremely-dangerous-substance-in-the-drug-trade |website=Finnish Customs |date=20 October 2025 |access-date=22 August 2025}}</ref><ref>{{cite journal | vauthors = Clayton J, Shi L, Robertson MJ, Skiniotis G, Michaelides M, Stavitskaya L, Shen J | date = August 2025 | title = A putative binding model of nitazene derivatives at the μ-opioid receptor | journal = Neuropharmacology | volume = 273 | article-number = 110437 | doi = 10.1016/j.neuropharm.2025.110437 | pmc = 12279083 | pmid = 40185362 }}</ref><ref>{{cite journal | vauthors = Hardwick EK, Couch AN, Davidson JT | date = March 2026 | title = Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool | journal = Rapid Communications in Mass Spectrometry | volume = 40 | issue = 5 | article-number = e70004 | doi = 10.1002/rcm.70004 | pmid = 41359886 }}</ref>
== See also == * Butodesnitazene * Etodesnitazene * Etomethazene * Metodesnitazene * Protonitazene * List of benzimidazole opioids
== References == {{reflist}}
{{Opioids}}
Category:Analgesics Category:Designer drugs Category:Benzimidazole opioids Category:Aromatic ethers Category:Diethylamino compounds Category:Propoxy compounds
{{Analgesic-stub}}