{{chembox | ImageFile = | ImageSize = | IUPACName = 1-ethenylpyrrolidin-2-one | OtherNames = {{Unbulleted list|Polyvinyl polypyrrolidone|crospovidone|crospolividone|E1202|Kollidon CL}} | Section1 = {{Chembox Identifiers | Abbreviations = PVPP | CASNo = 25249-54-1 | ChemSpiderID = none | PubChem = | ChEMBL = | SMILES = }} | Section2 = {{Chembox Properties | Formula = | MolarMass = | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} | Section6 = {{Chembox Pharmacology | ATCCode_prefix = A07 | ATCCode_suffix = BC03 }} | Section7 = {{Chembox Hazards | FlashPt = | AutoignitionPt = }} }} '''Polyvinylpolypyrrolidone''' ('''polyvinyl polypyrrolidone''', '''PVPP''', '''crospovidone''', '''crospolividone,''' or '''E1202''') is a highly cross-linked modification of polyvinylpyrrolidone (PVP).
This cross-linked form of PVP is used as a disintegrant (see also excipients) in pharmaceutical tablets.<ref>{{Cite web |title=Povidones, Copovidones, and Crospovidones for Pharmaceutical Products |url=https://pharma.basf.com/chemistry/povidones-copovidones-crospovidones |access-date=2022-06-11 |website=BASF Pharma |language=en-US}}</ref>
PVPP is insoluble in water, though it still absorbs water and swells very rapidly generating a swelling force. This property makes it useful as a disintegrant in tablets.{{citation needed|date=October 2025}}
PVPP can be used as a drug, taken as a tablet or suspension to absorb compounds (so-called endotoxins) that cause diarrhea. (''Cf.'' bone char, charcoal.){{citation needed|date=October 2025}}
It is also used as a fining to extract impurities (via agglomeration followed by filtration). It is used in winemaking. Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced.<ref>[http://www.sls.hw.ac.uk/components/staffDocs/G-2005-0718-294.pdf Microsoft Word - G0294.doc<!-- Bot generated title -->]{{Dead link|date=May 2017}}</ref> One such commercial product is called Polyclar. PVPP forms bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.<ref>{{Cite web |url=http://micro-report.com/wp-content/uploads/ISP_007_Stabilization_of_Beer_with_Polyclar_Brewbrite.pdf |title=A Novel Stabilization of Beer with Polyclar Brewbrite. Mustafa Rehmanji, Chandra Gopal, and Andrew Mola, MBAA TQ vol. 39, no. 1, 2002, pp. 24–28 |access-date=2017-05-19 |archive-url=https://web.archive.org/web/20150906062643/http://micro-report.com/wp-content/uploads/ISP_007_Stabilization_of_Beer_with_Polyclar_Brewbrite.pdf |archive-date=2015-09-06 |url-status=dead }}</ref>
PVPP is used as a stabiliser.{{citation needed|date=October 2025}}
== Safety == Autopsies have found that crospovidone/PVPP contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.<ref>{{Cite journal| pmid = 12692192| year = 2003| last1 = Ganesan| first1 = S| title = Embolized crospovidone (polyN-vinyl-2-pyrrolidone) in the lungs of intravenous drug users| journal = Modern Pathology| volume = 16| issue = 4| pages = 286–92| last2 = Felo| first2 = J| last3 = Saldana| first3 = M| last4 = Kalasinsky| first4 = V. F.| last5 = Lewin-Smith| first5 = M. R.| last6 = Tomashefski Jr| first6 = J. F.| doi = 10.1097/01.MP.0000062653.65441.DA| doi-access = free}}</ref>
==See also== *Polyethylene glycol-polyvinyl alcohol
==References== {{reflist|30em}}
Category:Vinyl polymers Category:Food additives Category:Pyrrolidones Category:Excipients Category:E-number additives