{{Infobox protein family | Symbol = Antimicrobial12 | Name = Antimicrobial12 | image = | width = | caption = solution structure and cell selectivity of piscidin 1 and its analogues | Pfam = PF08107 | Pfam_clan = | InterPro = IPR012515 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = 1.C.62 | OPM family = 142 | OPM protein = 1z64 | CAZy = | CDD = }} '''Pleurocidin''' is an antimicrobial peptide found in the mucus secreted by the skin of the winter flounder (Pleuronectes americanus). It exhibits broad-spectrum antimicrobial activity.<ref>{{Cite journal|title = Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications|journal = Journal of Food Science|date = 2004-04-01|issn = 1750-3841|pages = FMS66–FMS71|volume = 69|issue = 3|doi = 10.1111/j.1365-2621.2004.tb13373.x|language = en|first = O. J.|last = Burrowes|first2 = C.|last2 = Hadjicharalambous|first3 = G.|last3 = Diamond|first4 = Tung-Ching|last4 = Lee}}</ref> Pleurocidin assumes an amphipathic alpha-helical conformation similar to other linear antimicrobial peptides and may play a role in innate host defence.<ref name="pmid9115266">{{cite journal |vauthors=Cole AM, Weis P, Diamond G | title = Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder | journal = J. Biol. Chem. | volume = 272 | issue = 18 | pages = 12008–13 |date=May 1997 | pmid = 9115266 | doi = 10.1074/jbc.272.18.12008| doi-access = free }}</ref>
==Potential Applications== Pleurocidin has been noted for its potential use in food safety, in part due to its heat stable properties and clinically demonstrated effectiveness against common food-borne microorganisms.<ref>{{Cite journal|title = Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications|journal = Journal of Food Science|date = 2004-04-01|issn = 1750-3841|pages = FMS66–FMS71|volume = 69|issue = 3|doi = 10.1111/j.1365-2621.2004.tb13373.x|language = en|first = O. J.|last = Burrowes|first2 = C.|last2 = Hadjicharalambous|first3 = G.|last3 = Diamond|first4 = Tung-Ching|last4 = Lee}}</ref>
==References== {{reflist}} {{InterPro content|IPR012515}}
Category:Protein families Category:Antimicrobial peptides