'''Penola''' may refer to the following:
==Places== ;Antarctica *Penola Island *Penola Strait ;Australia *Penola, South Australia, a town and locality *Penola Conservation Park, a protected area in South Australia *Hundred of Penola, a cadastral unit in South Australia ;United States *Penola, Virginia, an unincorporated community in Virginia
==Ships== * ''Penola'', a sailing ship used for the British Graham Land expedition *SS Penola, a steamship
==Other== *''Penola'' (fly), a genus of flies in the family Sphaeroceridae *Penola Catholic College, a secondary school in Victoria, Australia
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