'''Peluffo''' is a surname. Notable people with the surname include:
* Ana Luisa Peluffo (1929–2026), Mexican actress * Luisa Peluffo (born 1941), Argentine writer and journalist * Mariano Peluffo (born 1971), Argentine TV host and producer * Norberto Peluffo (born 1958), Colombian footballer * Vinicio Peluffo (born 1971), Italian politician * Daniel Peluffo-Wiese (born 2003), American-born Uruguayan professional footballer
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Category:Spanish-language surnames