Pain wind-up

{{Short description|Perception of pain}} '''Pain wind-up''' is the increase in [[pain]] intensity over time when a given stimulus is delivered repeatedly above a critical rate. It is caused by repeated stimulation of [[group C nerve fiber|group C peripheral nerve fibers]], leading to progressively increasing electrical response in the corresponding spinal cord ([[posterior horn of spinal cord|posterior horn]]) neurons due to priming of the [[NMDA]] receptor based response.<ref name="XuLu2011">{{cite book|author1=Feng Xu|author2=Tianjian Lu|title=Introduction to Skin Biothermomechanics and Thermal Pain|url=https://books.google.com/books?id=fMggKzt8ofoC&pg=PA347|accessdate=25 April 2012|date=29 May 2011|publisher=Springer|isbn=978-3-642-13201-8|page=347}}</ref><ref name="Pitcher and Henry">Pitcher and Henry (2000). ''Eur. J. Neurosci.'', 12:2006–2020.</ref> It describes an exponentially progressive increase in firing of [[wide dynamic range neuron]] with repeated stimulation.

==References== <references/>

[[Category:Pain]]