PPP1R10

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Serine/threonine-protein phosphatase 1 regulatory subunit 10''' is an enzyme that in humans is encoded by the ''PPP1R10'' gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.<ref name="pmid9461602">{{cite journal | vauthors = Allen PB, Kwon YG, Nairn AC, Greengard P | title = Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit | journal = J Biol Chem | volume = 273 | issue = 7 | pages = 4089–95 |date=Mar 1998 | pmid = 9461602 | doi =10.1074/jbc.273.7.4089 | doi-access = free }}</ref><ref name="pmid9784381">{{cite journal | vauthors = Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P | title = Cloning of a new gene (FB19) within HLA class I region | journal = Biochem Biophys Res Commun | volume = 250 | issue = 3 | pages = 555–7 |date=Nov 1998 | pmid = 9784381 | doi = 10.1006/bbrc.1998.9354 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5514}}</ref>

== Function ==

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.<ref name="entrez"/>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Totaro A, Rommens JM, Grifa A, etal |title=Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region. |journal=Genomics |volume=31 |issue= 3 |pages= 319–26 |year= 1997 |pmid= 8838313 |doi= 10.1006/geno.1996.0054 }} *{{cite journal |vauthors=Kreivi JP, Trinkle-Mulcahy L, Lyon CE, etal |title=Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. |journal=FEBS Lett. |volume=420 |issue= 1 |pages= 57–62 |year= 1998 |pmid= 9450550 |doi=10.1016/S0014-5793(97)01485-3 |s2cid=23856958 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Kim YM, Watanabe T, Allen PB, etal |title=PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13819–28 |year= 2003 |pmid= 12574161 |doi= 10.1074/jbc.M209621200 |doi-access= free }} *{{cite journal |vauthors=Reeder JE, Sowden MP, Messing EM, etal |title=Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line. |journal= Cancer Cell International|volume=3 |issue= 1 |pages= 12 |year= 2003|pmid= 12914669 |doi= 10.1186/1475-2867-3-12 | pmc=183861 |doi-access=free }} *{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |doi-access= free }} *{{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }} *{{cite journal | vauthors=Raha-Chowdhury R, Andrews SR, Gruen JR |title=CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease. |journal=Brain Res. Mol. Brain Res. |volume=138 |issue= 1 |pages= 70–83 |year= 2005 |pmid= 15894402 |doi= 10.1016/j.molbrainres.2005.04.001 }} *{{cite journal |vauthors=Landsverk HB, Kirkhus M, Bollen M, etal |title=PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. |journal=Biochem. J. |volume=390 |issue= Pt 3 |pages= 709–17 |year= 2006 |pmid= 15907195 |doi= 10.1042/BJ20050678 | pmc=1199665 }} *{{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 }} *{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }} *{{cite journal |vauthors=Lee SJ, Lim CJ, Min JK, etal |title=Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2. |journal=Cell Death Differ. |volume=14 |issue= 6 |pages= 1106–16 |year= 2007 |pmid= 17318220 |doi= 10.1038/sj.cdd.4402111 |doi-access= free }} {{refend}}