PPEF1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Serine/threonine-protein phosphatase with EF-hands 1''' is an enzyme that in humans is encoded by the ''PPEF1'' gene.<ref name="pmid9215685">{{cite journal | vauthors = Montini E, Rugarli EI, Van de Vosse E, Andolfi G, Mariani M, Puca AA, Consalez GG, den Dunnen JT, Ballabio A, Franco B | title = A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin | journal = Human Molecular Genetics | volume = 6 | issue = 7 | pages = 1137–45 | date = Jul 1997 | pmid = 9215685 | doi = 10.1093/hmg/6.7.1137 | doi-access = free }}</ref><ref name="pmid9326663">{{cite journal | vauthors = Sherman PM, Sun H, Macke JP, Williams J, Smallwood PM, Nathans J | title = Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 21 | pages = 11639–44 | date = Oct 1997 | pmid = 9326663 | pmc = 23563 | doi = 10.1073/pnas.94.21.11639 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5475}}</ref>

== Function ==

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.<ref name="entrez" />

== Interactions ==

PPEF1 has been shown to interact with Calmodulin 1.<ref name=pmid12051765>{{cite journal | vauthors = Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N | title = Protein Ser/Thr phosphatases PPEF interact with calmodulin | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 3 | pages = 1047–52 | date = May 2002 | pmid = 12051765 | doi = 10.1016/S0006-291X(02)00338-8 | bibcode = 2002BBRC..293.1047K }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Herzig S, Neumann J | title = Effects of serine/threonine protein phosphatases on ion channels in excitable membranes | journal = Physiological Reviews | volume = 80 | issue = 1 | pages = 173–210 | date = Jan 2000 | pmid = 10617768 | doi = 10.1152/physrev.2000.80.1.173| s2cid = 17770945 }} * {{cite journal | vauthors = Huang X, Honkanen RE | title = Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC) | journal = The Journal of Biological Chemistry | volume = 273 | issue = 3 | pages = 1462–8 | date = Jan 1998 | pmid = 9430683 | doi = 10.1074/jbc.273.3.1462 | doi-access = free }} * {{cite journal | vauthors = Ramulu P, Kennedy M, Xiong WH, Williams J, Cowan M, Blesh D, Yau KW, Hurley JB, Nathans J | title = Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2) | journal = Molecular and Cellular Biology | volume = 21 | issue = 24 | pages = 8605–14 | date = Dec 2001 | pmid = 11713293 | pmc = 100021 | doi = 10.1128/MCB.21.24.8605-8614.2001 }} * {{cite journal | vauthors = Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N | title = Protein Ser/Thr phosphatases PPEF interact with calmodulin | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 3 | pages = 1047–52 | date = May 2002 | pmid = 12051765 | doi = 10.1016/S0006-291X(02)00338-8 | bibcode = 2002BBRC..293.1047K }} * {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }} * {{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biology | volume = 5 | issue = 2 | article-number = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 | doi-access = free }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} {{refend}}

Category:EF-hand-containing proteins