POLR2G

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''DNA-directed RNA polymerase II subunit RPB7''' is an [[enzyme]] that in humans is encoded by the ''POLR2G'' [[gene]].<ref name="pmid7579693">{{cite journal |vauthors=Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA | title = Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology | journal = Mol Biol Cell | volume = 6 | issue = 7 | pages = 759–75 |date=December 1995 | pmid = 7579693 | pmc = 301239 | doi = 10.1091/mbc.6.7.759}}</ref><ref name="pmid9256063">{{cite journal |vauthors=Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR | title = Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization | journal = Biochim Biophys Acta | volume = 1353 | issue = 1 | pages = 39–49 |date=August 1997 | pmid = 9256063 | doi = 10.1016/s0167-4781(97)00041-9| url = https://zenodo.org/record/1259891 }}</ref>

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.<ref>{{cite web | title = Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5436}}</ref>

==Interactions== POLR2G has been shown to [[Protein-protein interaction|interact]] with [[TAF15]],<ref name=pmid9488465>{{cite journal |last=Bertolotti |first=A |author2=Melot T |author3=Acker J |author4=Vigneron M |author5=Delattre O |author6=Tora L |date=March 1998 |title=EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes |journal=Mol. Cell. Biol. |volume=18 |issue=3 |pages=1489–97 |location = UNITED STATES| issn = 0270-7306| pmid = 9488465 |pmc=108863 | doi=10.1128/mcb.18.3.1489}}</ref> [[POLR2C]],<ref name=pmid9201987>{{cite journal |doi=10.1074/jbc.272.27.16815 |last=Acker |first=J |author2=de Graaff M |author3=Cheynel I |author4=Khazak V |author5=Kedinger C |author6=Vigneron M |date=July 1997 |title=Interactions between the human RNA polymerase II subunits |journal=J. Biol. Chem. |volume=272 |issue=27 |pages=16815–21 |location = UNITED STATES| issn = 0021-9258| pmid = 9201987 |doi-access=free }}</ref> [[POLR2H]]<ref name=pmid9201987/> and [[POLR2E]].<ref name=pmid9201987/>

==References== {{reflist}}

==Further reading== {{refbegin | 2}}

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