Phorbol-12-myristate-13-acetate-induced protein 1

{{cs1 config|name-list-style=vanc}} {{short description|Protein-coding gene in the species Homo sapiens}} {{redirect|Noxa|the Indonesian grindcore band|Noxa (band)}} {{Infobox_gene}} '''Phorbol-12-myristate-13-acetate-induced protein 1''' is a protein that in humans is encoded by the ''PMAIP1'' gene, and is also known as Noxa.<ref name="pmid2398525">{{cite journal | vauthors = Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K | title = Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line | journal = J Virol | volume = 64 | issue = 10 | pages = 4632–9 | date = October 1990 | pmid = 2398525 | pmc = 247947 | doi = 10.1128/JVI.64.10.4632-4639.1990}}</ref><ref name="pmid12879012">{{cite journal | vauthors = Jansson AK, Emterling AM, Arbman G, Sun XF | title = Noxa in colorectal cancer: a study on DNA, mRNA and protein expression | journal = Oncogene | volume = 22 | issue = 30 | pages = 4675–8 | date = July 2003 | pmid = 12879012 | doi = 10.1038/sj.onc.1206655 | doi-access = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5366}}</ref>

Noxa (Latin for ''damage'') is a pro-apoptotic member of the Bcl-2 protein family.<ref>{{cite journal | vauthors = Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N | title = Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis | journal = Science | volume = 288 | issue = 5468 | pages = 1053–1058 | date = May 2000 | pmid = 10807576 | doi = 10.1126/science.288.5468.1053 | bibcode = 2000Sci...288.1053O }}</ref> Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.

== Interactions == Noxa has been shown to interact with: * BCL2-like 1,<ref name = pmid15694340/><ref name = pmid10807576>{{cite journal | vauthors = Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N | title = Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis | journal = Science | volume = 288 | issue = 5468 | pages = 1053–8 | date = May 2000 | pmid = 10807576 | doi = 10.1126/science.288.5468.1053| bibcode = 2000Sci...288.1053O }}</ref> * Bcl-2,<ref name = pmid15694340/><ref name = pmid10807576/> and * MCL1.<ref name = pmid15694340>{{cite journal | vauthors = Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC | title = Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function | journal = Mol. Cell | volume = 17 | issue = 3 | pages = 393–403 | date = February 2005 | pmid = 15694340 | doi = 10.1016/j.molcel.2004.12.030 | doi-access = free }}</ref><ref name = pmid15901672>{{cite journal | vauthors = Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC | title = Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins | journal = Genes Dev. | volume = 19 | issue = 11 | pages = 1294–305 | date = June 2005 | pmid = 15901672 | pmc = 1142553 | doi = 10.1101/gad.1304105 }}</ref><ref>{{cite journal |last1=Heckmeier |first1=Philipp J. |last2=Ruf |first2=Jeannette |last3=Janković |first3=Brankica G. |last4=Hamm |first4=Peter |title=MCL-1 promiscuity and the structural resilience of its binding partners |journal=The Journal of Chemical Physics |date=7 March 2023 |volume=158 |issue=9 |doi=10.1063/5.0137239|pmid=36889945 |bibcode=2023JChPh.158i5101H |doi-access=free |arxiv=2211.08934 }}</ref>

== See also == * Apoptosis * Apoptosome * Bcl-2 * Bcl-2-associated X protein (BAX) * BH3 interacting domain death agonist (BID) * Caspases * Cytochrome c * Mitochondrion * p53 upregulated modulator of apoptosis (PUMA) * 12-''O''-Tetradecanoylphorbol-13-acetate (Phorbol-12-myristate-13-acetate)

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N | title = Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. | journal = Science | volume = 288 | issue = 5468 | pages = 1053–8 | year = 2000 | pmid = 10807576 | doi = 10.1126/science.288.5468.1053 | bibcode = 2000Sci...288.1053O }} * {{cite journal | vauthors = Seo YW, Shin JN, Ko KH, Cha JH, Park JY, Lee BR, Yun CW, Kim YM, Seol DW, Kim DW, Yin XM, Kim TH | title = The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death. | journal = J. Biol. Chem. | volume = 278 | issue = 48 | pages = 48292–9 | year = 2004 | pmid = 14500711 | doi = 10.1074/jbc.M308785200 | doi-access = free }} * {{cite journal | vauthors = Kim JY, Ahn HJ, Ryu JH, Suk K, Park JH | title = BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. | journal = J. Exp. Med. | volume = 199 | issue = 1 | pages = 113–24 | year = 2004 | pmid = 14699081 | pmc = 1887730 | doi = 10.1084/jem.20030613 }} * {{cite journal | vauthors = Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI | title = BOK and NOXA are essential mediators of p53-dependent apoptosis. | journal = J. Biol. Chem. | volume = 279 | issue = 27 | pages = 28367–74 | year = 2004 | pmid = 15102863 | doi = 10.1074/jbc.M313526200 | doi-access = free }} * {{cite journal | vauthors = Qin JZ, Stennett L, Bacon P, Bodner B, Hendrix MJ, Seftor RE, Seftor EA, Margaryan NV, Pollock PM, Curtis A, Trent JM, Bennett F, Miele L, Nickoloff BJ | title = p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. | journal = Mol. Cancer Ther. | volume = 3 | issue = 8 | pages = 895–902 | year = 2005 | doi = 10.1158/1535-7163.895.3.8 | pmid = 15299072 | s2cid = 34940117 | doi-access = free }} * {{cite journal | vauthors = Flinterman M, Guelen L, Ezzati-Nik S, Killick R, Melino G, Tominaga K, Mymryk JS, Gäken J, Tavassoli M | title = E1A activates transcription of p73 and Noxa to induce apoptosis. | journal = J. Biol. Chem. | volume = 280 | issue = 7 | pages = 5945–59 | year = 2005 | pmid = 15572378 | doi = 10.1074/jbc.M406661200 | doi-access = free | url = https://www.openaccessrepository.it/record/95333/files/fulltext.pdf | archive-url = https://web.archive.org/web/20240110152838/https://www.openaccessrepository.it/record/95333/files/fulltext.pdf | url-status = dead | archive-date = January 10, 2024 }} * {{cite journal | vauthors = Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC | title = Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. | journal = Mol. Cell | volume = 17 | issue = 3 | pages = 393–403 | year = 2005 | pmid = 15694340 | doi = 10.1016/j.molcel.2004.12.030 | doi-access = free }} * {{cite journal | vauthors = Sun Y, Leaman DW | title = Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection. | journal = J. Biol. Chem. | volume = 280 | issue = 16 | pages = 15561–8 | year = 2005 | pmid = 15705586 | doi = 10.1074/jbc.M412630200 | doi-access = free}} * {{cite journal | vauthors = Ceballos E, Muñoz-Alonso MJ, Berwanger B, Acosta JC, Hernández R, Krause M, Hartmann O, Eilers M, León J | title = Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes. | journal = Oncogene | volume = 24 | issue = 28 | pages = 4559–71 | year = 2005 | pmid = 15856024 | doi = 10.1038/sj.onc.1208652 | s2cid = 21190604 | doi-access = }} * {{cite journal | vauthors = Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC | title = Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. | journal = Genes Dev. | volume = 19 | issue = 11 | pages = 1294–305 | year = 2005 | pmid = 15901672 | pmc = 1142553 | doi = 10.1101/gad.1304105 }} * {{cite journal | vauthors = Alves NL, Derks IA, Berk E, Spijker R, van Lier RA, Eldering E | title = The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. | journal = Immunity | volume = 24 | issue = 6 | pages = 703–16 | year = 2006 | pmid = 16782027 | doi = 10.1016/j.immuni.2006.03.018 | doi-access = free }} * {{cite journal | vauthors = Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ | title = FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. | journal = Cell Death Differ. | volume = 14 | issue = 3 | pages = 534–47 | year = 2007 | pmid = 16888645 | doi = 10.1038/sj.cdd.4402017 | doi-access = free }} * {{cite journal | vauthors = Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY | title = Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. | journal = J. Biol. Chem. | volume = 281 | issue = 42 | pages = 31440–7 | year = 2006 | pmid = 16928686 | doi = 10.1074/jbc.M604356200 | doi-access = free}} * {{cite journal | vauthors = Smit LA, Hallaert DY, Spijker R, de Goeij B, Jaspers A, Kater AP, van Oers MH, van Noesel CJ, Eldering E | title = Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. | journal = Blood | volume = 109 | issue = 4 | pages = 1660–8 | year = 2007 | pmid = 17038534 | doi = 10.1182/blood-2006-05-021683 | s2cid = 16995479 | doi-access = }} * {{cite journal | vauthors = Armstrong JL, Veal GJ, Redfern CP, Lovat PE | title = Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours. | journal = Apoptosis | volume = 12 | issue = 3 | pages = 613–22 | year = 2007 | pmid = 17216584 | doi = 10.1007/s10495-006-0020-1 | s2cid = 41674871 }} * {{cite journal | vauthors = Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, et al. | title = NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer. | journal = Proc Natl Acad Sci USA | volume = 119 | issue = 9 | year = 2022 | pmid = 35197278 | pmc = 8892327| doi = 10.1073/pnas.2105691119 | doi-access = free | bibcode = 2022PNAS..11905691D }} {{refend}}

== External links == * {{MeshName|NOXA+protein,+human}}

Category:Programmed cell death Category:Proteins Category:Apoptosis Category:Anticancer genes