PLEKHO1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Pleckstrin homology domain-containing family O member 1''' is a protein that in humans is encoded by the ''PLEKHO1'' gene.<ref name="pmid10799509">{{cite journal | vauthors = Bosc DG, Graham KC, Saulnier RB, Zhang C, Prober D, Gietz RD, Litchfield DW | title = Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 19 | pages = 14295–306 | date = May 2000 | pmid = 10799509 | doi = 10.1074/jbc.275.19.14295 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLEKHO1 pleckstrin homology domain containing, family O member 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51177}}</ref>

== Interactions ==

PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1<ref name=pmid10799509 /> and SMURF1.<ref name=pmid18641638>{{cite journal | vauthors = Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L, He F | title = Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1 | journal = Nature Cell Biology | volume = 10 | issue = 8 | pages = 994–1002 | date = August 2008 | pmid = 18641638 | doi = 10.1038/ncb1760 | s2cid = 19216909 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }} * {{cite journal | vauthors = Olsten ME, Canton DA, Zhang C, Walton PA, Litchfield DW | title = The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane | journal = The Journal of Biological Chemistry | volume = 279 | issue = 40 | pages = 42114–27 | date = October 2004 | pmid = 15254037 | doi = 10.1074/jbc.M407628200 | doi-access = free }} * {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }} * {{cite journal | vauthors = Zhang L, Xing G, Tie Y, Tang Y, Tian C, Li L, Sun L, Wei H, Zhu Y, He F | title = Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis | journal = The EMBO Journal | volume = 24 | issue = 4 | pages = 766–78 | date = February 2005 | pmid = 15706351 | pmc = 549613 | doi = 10.1038/sj.emboj.7600532 }} * {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = March 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 | bibcode = 2005Sci...307.1621B | s2cid = 39457788 }} * {{cite journal | vauthors = Canton DA, Olsten ME, Kim K, Doherty-Kirby A, Lajoie G, Cooper JA, Litchfield DW | title = The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein | journal = Molecular and Cellular Biology | volume = 25 | issue = 9 | pages = 3519–34 | date = May 2005 | pmid = 15831458 | pmc = 1084316 | doi = 10.1128/MCB.25.9.3519-3534.2005 | url = http://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=3252&context=open_access_pubs }} * {{cite journal | vauthors = Zhang L, Tie Y, Tian C, Xing G, Song Y, Zhu Y, Sun Z, He F | title = CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM | journal = Cellular Signalling | volume = 18 | issue = 9 | pages = 1386–95 | date = September 2006 | pmid = 16325375 | doi = 10.1016/j.cellsig.2005.10.017 }} * {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }} * {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 | s2cid = 13709685 | doi-access = free }} * {{cite journal | vauthors = Canton DA, Olsten ME, Niederstrasser H, Cooper JA, Litchfield DW | title = The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein | journal = The Journal of Biological Chemistry | volume = 281 | issue = 47 | pages = 36347–59 | date = November 2006 | pmid = 16987810 | pmc = 2583070 | doi = 10.1074/jbc.M607595200 | doi-access = free }} * {{cite journal | vauthors = Zhang L, Tang Y, Tie Y, Tian C, Wang J, Dong Y, Sun Z, He F | title = The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling | journal = Cellular Signalling | volume = 19 | issue = 5 | pages = 932–44 | date = May 2007 | pmid = 17197158 | doi = 10.1016/j.cellsig.2006.11.002 }} * {{cite journal | vauthors = Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R, Itoh T, Takenawa T, Miyazono K, Tsuruo T | title = Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo | journal = Cancer Research | volume = 67 | issue = 20 | pages = 9666–76 | date = October 2007 | pmid = 17942896 | doi = 10.1158/0008-5472.CAN-07-1050 | doi-access = free }} {{refend}}