PLEKHA1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Pleckstrin homology domain-containing family A member 1''' is a protein that in humans is encoded by the ''PLEKHA1'' gene.<ref name="pmid11001876">{{cite journal | vauthors = Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR | title = Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities | journal = Biochem J | volume = 351 | issue = Pt 1 | pages = 19–31 | date = Jan 2001 | pmid = 11001876 | pmc = 1221362 | doi = 10.1042/0264-6021:3510019 }}</ref><ref name="pmid15485858">{{cite journal | vauthors = Hogan A, Yakubchyk Y, Chabot J, Obagi C, Daher E, Maekawa K, Gee SH | title = The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization | journal = J Biol Chem | volume = 279 | issue = 51 | pages = 53717–24 | date = Dec 2004 | pmid = 15485858 | doi = 10.1074/jbc.M410654200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=59338}}</ref>

== Interactions ==

PLEKHA1 has been shown to interact with MPDZ.<ref name=pmid11802782>{{cite journal | vauthors = Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR | title = Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 525–36 | date = Feb 2002 | pmid = 11802782 | pmc = 1222335 | doi = 10.1042/0264-6021:3610525 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM | title = Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity | journal = Biochem. J. | volume = 358 | issue = Pt 2 | pages = 287–94 | year = 2001 | pmid = 11513726 | pmc = 1222060 | doi = 10.1042/0264-6021:3580287 }} * {{cite journal | vauthors = Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR | title = Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 525–36 | year = 2002 | pmid = 11802782 | pmc = 1222335 | doi = 10.1042/0264-6021:3610525 }} * {{cite journal | vauthors = Marshall AJ, Krahn AK, Ma K, Duronio V, Hou S | title = TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor | journal = Mol. Cell. Biol. | volume = 22 | issue = 15 | pages = 5479–91 | year = 2002 | pmid = 12101241 | pmc = 133950 | doi = 10.1128/MCB.22.15.5479-5491.2002 }} * {{cite journal | vauthors = Kimber WA, Deak M, Prescott AR, Alessi DR | title = Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1 | journal = Biochem. J. | volume = 376 | issue = Pt 2 | pages = 525–35 | year = 2003 | pmid = 14516276 | pmc = 1223793 | doi = 10.1042/BJ20031154 }} * {{cite journal | vauthors = Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB | title = Susceptibility Genes for Age-Related Maculopathy on Chromosome 10q26 | journal = Am. J. Hum. Genet. | volume = 77 | issue = 3 | pages = 389–407 | year = 2006 | pmid = 16080115 | pmc = 1226205 | doi = 10.1086/444437 }} {{refend}}