PLA2R1

{{Infobox_gene}} '''Secretory phospholipase A2 receptor''' is a protein that in humans is encoded by the ''PLA2R1'' gene.<ref name="pmid7721806">{{cite journal | vauthors = Ancian P, Lambeau G, Mattéi MG, Lazdunski M | title = The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization | journal = The Journal of Biological Chemistry | volume = 270 | issue = 15 | pages = 8963–70 | date = Apr 1995 | pmid = 7721806 | doi = 10.1074/jbc.270.15.8963 | doi-access = free }}</ref><ref name="pmid7925459">{{cite journal | vauthors = Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H | title = Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals | journal = European Journal of Biochemistry | volume = 225 | issue = 1 | pages = 375–82 | date = Oct 1994 | pmid = 7925459 | doi = 10.1111/j.1432-1033.1994.00375.x | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=22925}}</ref>

== Clinical significance ==

M-type phospholipase A2 receptor is the major antigen in idiopathic membranous nephropathy attributed to over 70% of cases.<ref>{{cite journal | vauthors = Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ | title = M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy | journal = The New England Journal of Medicine | volume = 361 | issue = 1 | pages = 11–21 | date = Jul 2009 | pmid = 19571279 | pmc = 2762083 | doi = 10.1056/NEJMoa0810457 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Silliman CC, Moore EE, Zallen G, Gonzalez R, Johnson JL, Elzi DJ, Meng X, Hanasaki K, Ishizaki J, Arita H, Ao L, England KM, Banerjee A | title = Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion | journal = American Journal of Physiology. Cell Physiology | volume = 283 | issue = 4 | pages = C1102–13 | date = Oct 2002 | pmid = 12225974 | doi = 10.1152/ajpcell.00608.2001 }} * {{cite journal | vauthors = Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts | journal = Molecular Vision | volume = 8 | pages = 196–204 | date = Jun 2002 | pmid = 12107411 }} * {{cite journal | vauthors = Morioka Y, Saiga A, Yokota Y, Suzuki N, Ikeda M, Ono T, Nakano K, Fujii N, Ishizaki J, Arita H, Hanasaki K | title = Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor | journal = Archives of Biochemistry and Biophysics | volume = 381 | issue = 1 | pages = 31–42 | date = Sep 2000 | pmid = 11019817 | doi = 10.1006/abbi.2000.1977 }} * {{cite journal | vauthors = Yokota Y, Higashino K, Nakano K, Arita H, Hanasaki K | title = Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor | journal = FEBS Letters | volume = 478 | issue = 1–2 | pages = 187–91 | date = Jul 2000 | pmid = 10922494 | doi = 10.1016/S0014-5793(00)01848-2 | s2cid = 28188560 | doi-access = free }} * {{cite journal | vauthors = Yokota Y, Ikeda M, Higashino K, Nakano K, Fujii N, Arita H, Hanasaki K | title = Enhanced tissue expression and elevated circulating level of phospholipase A(2) receptor during murine endotoxic shock | journal = Archives of Biochemistry and Biophysics | volume = 379 | issue = 1 | pages = 7–17 | date = Jul 2000 | pmid = 10864436 | doi = 10.1006/abbi.2000.1849 }} * {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3491–6 | date = Mar 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 | bibcode = 2000PNAS...97.3491D | doi-access = free }} {{refend}}