'''Pepo''' may refer to:
*Pepo (botany), a modified berry with a hard outer rind, typical of cucurbits such as cucumbers and melons **''Pepo'' <small>Mill.</small>, a synonym of the genus ''Cucurbita'' *Pepo (ethnology), Plains Indigenous peoples in Taiwan *Pepo (jurist), an 11th-century law teacher at the University of Bologna *Pepo (cartoonist), born René Ríos Boettiger, a Chilean cartoonist, who used Pepo as a pseudonym *PEPO Lappeenranta, a Finnish football club *''Pepo'' (film), a 1935 Armenian film made by Hamo Beknazarian *Pepo Frick (born 1952), Liechtenstein politician *Nickname of Susilo Bambang Yudhoyono
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