PECR

Peroxisomal trans-2-enoyl-CoA reductase is an enzyme that in humans is encoded by the PECR gene.^[1][2][3][4] Research suggests that the (human) enzyme participates in the conversion of phytol to phytanic acid in the peroxisomes, which is part of the process of breaking down phytol.^[5] In particular, it catalyzes reactions of the form:

a (2E)-enoyl-CoA + NADPH + H⁺ \rightleftharpoons a 2,3-saturated acyl-CoA + NADP⁺

With affinity for trans-2-enoyl-CoAs of lengths between 4:1 and 16:1.^[5]

See Also

• MECR

References

1. ^ Das AK, Uhler MD, Hajra AK (Sep 2000). "Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs". J Biol Chem. 275 (32): 24333–40. doi:10.1074/jbc.M001168200. PMID 10811639
2. ^ Amery L, Mannaerts GP, Subramani S, Van Veldhoven PP, Fransen M (Oct 2001). "Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology". Comb Chem High Throughput Screen. 4 (7): 545–52. doi:10.2174/1386207013330832. PMID 11669066
3. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726
4. ^ "Entrez Gene: PECR peroxisomal trans-2-enoyl-CoA reductase"
5. ^ Gloerich J, Ruiter JP, van den Brink DM, Ofman R, Ferdinandusse S, Wanders RJ (2006-04-03). "Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation". FEBS Lett. 580 (8): 2092-6. doi:10.1016/j.febslet.2006.03.011. PMID 16546181

Further reading

• Gay F, Anglade I, Gong Z, Salbert G (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Mol. Endocrinol.. 14 (10): 1627–48. doi:10.1210/mend.14.10.0538. PMID 11043578
• Jia L; Young MF; Powell J; Yang, Liming; Ho, Nicola C.; Hotchkiss, Robert; Robey, Pamela Gehron; Francomano, Clair A. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452
• Braastad CD, Leguia M, Hendrickson EA (2002). "Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element". Nucleic Acids Res.. 30 (8): 1713–24. doi:10.1093/nar/30.8.1713. PMC 113227. PMID 11937624
• Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM; Schuler, GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
• Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S; Rasooly, R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res.. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334
• Hillier LW; Graves TA; Fulton RS; Fulton, Lucinda A.; Pepin, Kymberlie H.; Minx, Patrick; Wagner-Mcpherson, Caryn; Layman, Dan; Wylie, Kristine (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621
• Gloerich J; Ruiter JP; van den Brink DM; Ofman, R; Ferdinandusse, S; Wanders, R (2006). "Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation". FEBS Lett.. 580 (8): 2092–6. doi:10.1016/j.febslet.2006.03.011. PMID 16546181. S2CID 34148550