PDS5B

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Sister chromatid cohesion protein PDS5 homolog B''' '''(PDS5B)''' is a protein that in humans is encoded by the ''PDS5B'' gene.<ref name="pmid8812419">{{cite journal |vauthors=Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J | title = Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13 | journal = Genomics | volume = 36 | issue = 1 | pages = 86–99 |date=Feb 1997 | pmid = 8812419 | doi =10.1006/geno.1996.0428 |display-authors=etal| doi-access = free }}</ref><ref name="pmid10215036">{{cite journal |vauthors=Geck P, Szelei J, Jimenez J, Sonnenschein C, Soto AM | title = Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus | journal = J Steroid Biochem Mol Biol | volume = 68 | issue = 1–2 | pages = 41–50 |date=May 1999 | pmid = 10215036 | doi =10.1016/S0960-0760(98)00165-4 | s2cid = 32542980 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: APRIN androgen-induced proliferation inhibitor| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23047}}</ref> It is a regulatory subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by ESCO1 and ESCO2.

==References== {{reflist}}

Category:Genes mutated in mice Category:Genes on human chromosome 13