PCDH10

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Protocadherin-10''' is a protein that in humans is encoded by the ''PCDH10'' gene.<ref name="pmid10835267">{{cite journal |vauthors=Nollet F, Kools P, van Roy F | title = Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members | journal = J Mol Biol | volume = 299 | issue = 3 | pages = 551–72 |date=Jul 2000 | pmid = 10835267 | doi = 10.1006/jmbi.2000.3777 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCDH10 protocadherin 10| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=57575}}</ref>

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.<ref name="entrez" />

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169|s2cid=44844497 |doi-access=free }} *{{cite journal |vauthors=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236–44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236 |s2cid=12847618 }} *{{cite journal |vauthors=Wu Q, Maniatis T |title=A striking organization of a large family of human neural cadherin-like cell adhesion genes |journal=Cell |volume=97 |issue= 6 |pages= 779–90 |year= 1999 |pmid= 10380929 |doi=10.1016/S0092-8674(00)80789-8 |s2cid=6014717 |doi-access=free }} *{{cite journal |vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 |doi-access=free }} *{{cite journal | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65 |name-list-style=vanc| author2=Kikuno R | author3=Ishikawa KI | display-authors=3 | last4=Hirosawa | first4=M | last5=Ohara | first5=O |doi-access=free}} *{{cite journal | author=Wu Q |title=Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters |journal=Genome Res. |volume=11 |issue= 3 |pages= 389–404 |year= 2001 |pmid= 11230163 |doi= 10.1101/gr.167301 | pmc=311048 |name-list-style=vanc| author2=Zhang T | author3=Cheng JF | display-authors=3 | last4=Kim | first4=Y | last5=Grimwood | first5=J | last6=Schmutz | first6=J | last7=Dickson | first7=M | last8=Noonan | first8=JP | last9=Zhang | first9=MQ }} *{{cite journal |vauthors=Wolverton T, Lalande M |title=Identification and characterization of three members of a novel subclass of protocadherins |journal=Genomics |volume=76 |issue= 1–3 |pages= 66–72 |year= 2001 |pmid= 11549318 |doi= 10.1006/geno.2001.6592 }} *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal | author=Ying J |title=Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation |journal=Oncogene |volume=25 |issue= 7 |pages= 1070–80 |year= 2006 |pmid= 16247458 |doi= 10.1038/sj.onc.1209154 |name-list-style=vanc| author2=Li H | author3=Seng TJ | display-authors=3 | last4=Langford | first4=C | last5=Srivastava | first5=G | last6=Tsao | first6=S W | last7=Putti | first7=T | last8=Murray | first8=P | last9=Chan | first9=A T C |s2cid=11573872 }} {{refend}}