PACSIN2

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Protein kinase C and casein kinase substrate in neurons protein 2''' (Pacsin 2) is a protein that in humans is encoded by the ''PACSIN2'' gene.<ref name="pmid10431838">{{cite journal | vauthors = Ritter B, Modregger J, Paulsson M, Plomann M | title = PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins | journal = FEBS Lett | volume = 454 | issue = 3 | pages = 356–62 | date = Aug 1999 | pmid = 10431838 | doi = 10.1016/S0014-5793(99)00830-3 | s2cid = 44788141 | doi-access = free }}</ref><ref name="pmid11082044">{{cite journal | vauthors = Modregger J, Ritter B, Witter B, Paulsson M, Plomann M | title = All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis | journal = J Cell Sci | volume = 113 | issue = 24| pages = 4511–21 | date = Jan 2001 | doi = 10.1242/jcs.113.24.4511 | pmid = 11082044 }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: PACSIN2 protein kinase C and casein kinase substrate in neurons 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11252}}</ref> Pacsin 2 is involved in the formation of caveolae.<ref>{{cite journal|last1=Shvets|first1=E|last2=Ludwig|first2=A|last3=Nichols|first3=BJ|title=News from the caves: update on the structure and function of caveolae.|journal=Current Opinion in Cell Biology|date=August 2014|volume=29|pages=99–106|pmid=24908346|doi=10.1016/j.ceb.2014.04.011}}</ref>

The variant rs2413739 in PACSIN2 has been associated with the activity of the enzyme thiopurine-methyltransferase during remission maintenance therapy of children with acute lymphoblastic leukemia and with the incidence of severe gastrointestinal adverse events during remission consolidation therapy of children with acute lymphoblastic leukemia, based mostly on the antimetabolites mercaptopurine and methotrexate.<ref>{{cite journal|title = PACSIN2 rs2413739 Influence on Thiopurine Pharmacokinetics: Validation Studies in Pediatric Patients |journal = The Pharmacogenomics Journal |year = 2020 |doi = 10.1038/s41397-019-0130-0|hdl = 2318/1757668 |hdl-access = free |last1 = Franca |first1 = Raffaella |last2 = Stocco |first2 = Gabriele |last3 = Favretto |first3 = Diego |last4 = Giurici |first4 = Nagua |last5 = Del Rizzo |first5 = Irene |last6 = Locatelli |first6 = Franco |last7 = Vinti |first7 = Luciana |last8 = Biondi |first8 = Andrea |last9 = Colombini |first9 = Antonella |last10 = Fagioli |first10 = Franca |last11 = Barisone |first11 = Elena |last12 = Pelin |first12 = Marco |last13 = Martellossi |first13 = Stefano |last14 = Ventura |first14 = Alessandro |last15 = Decorti |first15 = Giuliana |last16 = Rabusin |first16 = Marco |volume = 20 |issue = 3 |pages = 415–425 |pmid = 31792371 |s2cid = 208539277 }}</ref>

== Interactions ==

PACSIN2 has been shown to interact with: * Fas ligand,<ref name = pmid12023017>{{cite journal | vauthors = Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O | title = Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) | journal = FEBS Lett. | volume = 519 | issue = 1–3 | pages = 50–8 | date = May 2002 | pmid = 12023017 | doi = 10.1016/s0014-5793(02)02709-6| s2cid = 26765451 }}</ref> * PACSIN1,<ref name = pmid11082044 /><ref name = pmid16189514>{{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}</ref> and * PACSIN3.<ref name = pmid11082044/>

== References == {{Reflist}}

== Further reading == {{Refbegin| 2}} * {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }} * {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }} * {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 | bibcode = 1999Natur.402..489D | doi-access = free }} * {{cite journal | vauthors = Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M | title = PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family | journal = Gene | volume = 262 | issue = 1–2 | pages = 199–205 | year = 2001 | pmid = 11179684 | doi = 10.1016/S0378-1119(00)00531-X }} * {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }} * {{cite journal | vauthors = Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O | title = Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) | journal = FEBS Lett. | volume = 519 | issue = 1–3 | pages = 50–8 | year = 2002 | pmid = 12023017 | doi = 10.1016/S0014-5793(02)02709-6 | s2cid = 26765451 }} * {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biol. | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 | doi-access = free }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} * {{cite journal | vauthors = Kessels MM, Dong J, Leibig W, Westermann P, Qualmann B | title = Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network | journal = J. Cell Sci. | volume = 119 | issue = Pt 8 | pages = 1504–16 | year = 2006 | pmid = 16551695 | doi = 10.1242/jcs.02877 | doi-access = free }} * {{cite journal | vauthors = Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S | title = PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4 | journal = J. Biol. Chem. | volume = 281 | issue = 27 | pages = 18753–62 | year = 2006 | pmid = 16627472 | doi = 10.1074/jbc.M602452200 | doi-access = free | hdl = 2066/51163 | hdl-access = free }} * {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | doi-access = free }} {{Refend}}