PA2G4

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Proliferation-associated protein 2G4''' (PA2G4) also known as '''ErbB3-binding protein 1''' (EBP1) is a protein that in humans is encoded by the ''PA2G4'' gene.<ref name="pmid9345902">{{cite journal | vauthors = Lamartine J, Seri M, Cinti R, Heitzmann F, Creaven M, Radomski N, Jost E, Lenoir GM, Romeo G, Sylla BS | title = Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4 | journal = Cytogenetics and Cell Genetics | volume = 78 | issue = 1 | pages = 31–5 | date = November 1997 | pmid = 9345902 | doi = 10.1159/000134621 }}</ref>

== Function ==

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional corepressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Paradoxically, the expression of EBP1 is decreased in prostate cancer,<ref>{{cite journal | vauthors = Zhang Y, Linn D, Liu Z, Melamed J, Tavora F, Young CY, Burger AM, Hamburger AW | title = EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance | journal = Molecular Cancer Therapeutics | volume = 7 | issue = 10 | pages = 3176–86 | date = October 2008 | pmid = 18852121 | pmc = 2629587 | doi = 10.1158/1535-7163.MCT-08-0526 }}</ref> but increased in Acute Myelogneous Leukemia.<ref>{{cite journal | vauthors = Nguyen le XT, Zhu L, Lee Y, Ta L, Mitchell BS | title = Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells | journal = Clinical Cancer Research | volume = 22 | issue = 13 | pages = 3320–7 | date = July 2016 | pmid = 26813358 | doi = 10.1158/1078-0432.CCR-15-2282 | doi-access = free }}</ref> Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: PA2G4 proliferation-associated 2G4, 38kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5036}}</ref>

== Interactions ==

PA2G4 has been shown to interact with ERBB3,<ref name="pmid11325528">{{cite journal | vauthors = Lessor TJ, Hamburger AW | title = Regulation of the ErbB3 binding protein Ebp1 by protein kinase C | journal = Molecular and Cellular Endocrinology | volume = 175 | issue = 1–2 | pages = 185–91 | date = April 2001 | pmid = 11325528 | doi = 10.1016/S0303-7207(01)00387-2 | s2cid = 43143635 }}</ref><ref name="pmid10682683">{{cite journal | vauthors = Yoo JY, Wang XW, Rishi AK, Lessor T, Xia XM, Gustafson TA, Hamburger AW | title = Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin | journal = British Journal of Cancer | volume = 82 | issue = 3 | pages = 683–90 | date = February 2000 | pmid = 10682683 | pmc = 2363329 | doi = 10.1054/bjoc.1999.0981 }}</ref> retinoblastoma protein,<ref name="pmid11268000">{{cite journal | vauthors = Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW | title = Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation | journal = Journal of Cellular Physiology | volume = 187 | issue = 2 | pages = 209–17 | date = May 2001 | pmid = 11268000 | doi = 10.1002/jcp.1075 | s2cid = 42721280 }}</ref> and androgen receptor.<ref name="pmid12165860">{{cite journal | vauthors = Zhang Y, Fondell JD, Wang Q, Xia X, Cheng A, Lu ML, Hamburger AW | title = Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1 | journal = Oncogene | volume = 21 | issue = 36 | pages = 5609–18 | date = August 2002 | pmid = 12165860 | doi = 10.1038/sj.onc.1205638 | doi-access = free }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Radomski N, Jost E | title = Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle | journal = Experimental Cell Research | volume = 220 | issue = 2 | pages = 434–45 | date = October 1995 | pmid = 7556453 | doi = 10.1006/excr.1995.1335 }} * {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }} * {{cite journal | vauthors = Froesch BA, Takayama S, Reed JC | title = BAG-1L protein enhances androgen receptor function | journal = The Journal of Biological Chemistry | volume = 273 | issue = 19 | pages = 11660–6 | date = May 1998 | pmid = 9565586 | doi = 10.1074/jbc.273.19.11660 | doi-access = free }} * {{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members | journal = The Journal of Biological Chemistry | volume = 274 | issue = 53 | pages = 37538–43 | date = December 1999 | pmid = 10608806 | doi = 10.1074/jbc.274.53.37538 | doi-access = free }} * {{cite journal | vauthors = Yoo JY, Wang XW, Rishi AK, Lessor T, Xia XM, Gustafson TA, Hamburger AW | title = Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin | journal = British Journal of Cancer | volume = 82 | issue = 3 | pages = 683–90 | date = February 2000 | pmid = 10682683 | pmc = 2363329 | doi = 10.1054/bjoc.1999.0981 }} * {{cite journal | vauthors = Lessor TJ, Yoo JY, Xia X, Woodford N, Hamburger AW | title = Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines | journal = Journal of Cellular Physiology | volume = 183 | issue = 3 | pages = 321–9 | date = June 2000 | pmid = 10797306 | doi = 10.1002/(SICI)1097-4652(200006)183:3<321::AID-JCP4>3.0.CO;2-O | s2cid = 1973521 }} * {{cite journal | vauthors = Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW | title = Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation | journal = Journal of Cellular Physiology | volume = 187 | issue = 2 | pages = 209–17 | date = May 2001 | pmid = 11268000 | doi = 10.1002/jcp.1075 | s2cid = 42721280 }} * {{cite journal | vauthors = Lessor TJ, Hamburger AW | title = Regulation of the ErbB3 binding protein Ebp1 by protein kinase C | journal = Molecular and Cellular Endocrinology | volume = 175 | issue = 1–2 | pages = 185–91 | date = April 2001 | pmid = 11325528 | doi = 10.1016/S0303-7207(01)00387-2 | s2cid = 43143635 }} * {{cite journal | vauthors = Xia X, Lessor TJ, Zhang Y, Woodford N, Hamburger AW | title = Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein | journal = Biochemical and Biophysical Research Communications | volume = 289 | issue = 1 | pages = 240–4 | date = November 2001 | pmid = 11708806 | doi = 10.1006/bbrc.2001.5942 }} * {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = January 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free | bibcode = 2002CBio...12....1A }} * {{cite journal | vauthors = Zhang Y, Fondell JD, Wang Q, Xia X, Cheng A, Lu ML, Hamburger AW | title = Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1 | journal = Oncogene | volume = 21 | issue = 36 | pages = 5609–18 | date = August 2002 | pmid = 12165860 | doi = 10.1038/sj.onc.1205638 | doi-access = free }} * {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4100–9 | date = November 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }} * {{cite journal | vauthors = Zhang Y, Woodford N, Xia X, Hamburger AW | title = Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases | journal = Nucleic Acids Research | volume = 31 | issue = 8 | pages = 2168–77 | date = April 2003 | pmid = 12682367 | pmc = 153746 | doi = 10.1093/nar/gkg318 }} * {{cite journal | vauthors = Squatrito M, Mancino M, Donzelli M, Areces LB, Draetta GF | title = EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes | journal = Oncogene | volume = 23 | issue = 25 | pages = 4454–65 | date = May 2004 | pmid = 15064750 | doi = 10.1038/sj.onc.1207579 | doi-access = free }} * {{cite journal | vauthors = Zhang Y, Hamburger AW | title = Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription | journal = The Journal of Biological Chemistry | volume = 279 | issue = 25 | pages = 26126–33 | date = June 2004 | pmid = 15073182 | doi = 10.1074/jbc.M314305200 | doi-access = free }} * {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = July 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }} * {{cite journal | vauthors = Zhang Y, Hamburger AW | title = Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling | journal = British Journal of Cancer | volume = 92 | issue = 1 | pages = 140–6 | date = January 2005 | pmid = 15583694 | pmc = 2361729 | doi = 10.1038/sj.bjc.6602257 }} {{refend}}