LPAR6

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{Infobox_gene}}

'''Lysophosphatidic acid receptor 6''', also known as '''LPA<sub>6</sub>''', '''P2RY5''' and '''GPR87''', is a protein that in humans is encoded by the ''LPAR6'' gene.<ref name="pmid11004484">{{cite journal | vauthors = Adrian K, Bernhard MK, Breitinger HG, Ogilvie A | title = Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1492 | issue = 1 | pages = 127–138 | date = June 2000 | pmid = 11004484 | doi = 10.1016/S0167-4781(00)00094-4 }}</ref><ref name="pmid9755289">{{cite journal | vauthors = Ralevic V, Burnstock G | title = Receptors for purines and pyrimidines | journal = Pharmacological Reviews | volume = 50 | issue = 3 | pages = 413–492 | date = September 1998 | pmid = 9755289 }}</ref><ref name="pmid19386608">{{cite journal | vauthors = Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S | title = Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6 | journal = The Journal of Biological Chemistry | volume = 284 | issue = 26 | pages = 17731–17741 | date = June 2009 | pmid = 19386608 | pmc = 2719412 | doi = 10.1074/jbc.M808506200 | doi-access = free }}</ref><ref name="entrez"/> LPA<sub>6</sub> is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).<ref name="pmid18297070">{{cite journal | vauthors = Pasternack SM, von Kügelgen I, Al Aboud K, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC | title = G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth | journal = Nature Genetics | volume = 40 | issue = 3 | pages = 329–334 | date = March 2008 | pmid = 18297070 | doi = 10.1038/ng.84 | s2cid = 20241237 }}</ref><ref name = "Choi_2010">{{cite journal | vauthors = Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J | title = LPA receptors: subtypes and biological actions | journal = Annual Review of Pharmacology and Toxicology | volume = 50 | issue = 1 | pages = 157–186 | date = January 2010 | pmid = 20055701 | doi = 10.1146/annurev.pharmtox.010909.105753 }}</ref>

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10161}}</ref>

== Role in hair growth/loss ==

In February 2008, researchers at the University of Bonn announced they have found the genetic basis of two distinct forms of inherited hair loss, opening a broad path to treatments for baldness. They found that mutations in the gene P2RY5 causes a rare, inherited form of hair loss called hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in hair growth was previously unknown to scientists, and with this new knowledge a focus on finding more of these genes may be able to lead to therapies for many different types of hair loss.<ref name="pmid18297070"/><ref>{{Cite web |title=Hypotrichosis simplex - About the Disease - Genetic and Rare Diseases Information Center |url=https://rarediseases.info.nih.gov/diseases/9170/hypotrichosis-simplex/ |access-date=2023-05-06 |website=rarediseases.info.nih.gov |language=en}}</ref>

In 2013, it was found that mutations in ''LPAR6'' give rise to the Cornish Rex cat breed, which has a form of ectodermal dysplasia characterised by short woolly hair which is susceptible to loss.<ref>{{cite journal | vauthors = Gandolfi B, Alhaddad H, Affolter VK, Brockman J, Haggstrom J, Joslin SE, Koehne AL, Mullikin JC, Outerbridge CA, Warren WC, Lyons LA | title = To the Root of the Curl: A Signature of a Recent Selective Sweep Identifies a Mutation That Defines the Cornish Rex Cat Breed | journal = PLOS ONE | volume = 8 | issue = 6 | article-number = e67105 | date = 2013-06-27 | pmid = 23826204 | pmc = 3694948 | doi = 10.1371/journal.pone.0067105 | doi-access = free | bibcode = 2013PLoSO...867105G }}</ref>

== See also == * Lysophospholipid receptor * P2Y receptor {{clear}} == References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Toguchida J, McGee TL, Paterson JC, Eagle JR, Tucker S, Yandell DW, Dryja TP | title = Complete genomic sequence of the human retinoblastoma susceptibility gene | journal = Genomics | volume = 17 | issue = 3 | pages = 535–543 | date = September 1993 | pmid = 7902321 | doi = 10.1006/geno.1993.1368 }} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Herzog H, Darby K, Hort YJ, Shine J | title = Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene | journal = Genome Research | volume = 6 | issue = 9 | pages = 858–861 | date = September 1996 | pmid = 8889552 | doi = 10.1101/gr.6.9.858 | doi-access = free }} * {{cite journal | vauthors = Li Q, Schachter JB, Harden TK, Nicholas RA | title = The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses | journal = Biochemical and Biophysical Research Communications | volume = 236 | issue = 2 | pages = 455–460 | date = July 1997 | pmid = 9240460 | doi = 10.1006/bbrc.1997.6984 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Ihara H, Hirukawa K, Goto S, Togari A | title = ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts | journal = Biochemical and Biophysical Research Communications | volume = 326 | issue = 2 | pages = 329–334 | date = January 2005 | pmid = 15582581 | doi = 10.1016/j.bbrc.2004.11.037 }} {{refend}}

== External links == * {{UCSC genome browser|LPAR6}} * {{UCSC gene details|LPAR6}}

Category:G protein-coupled receptors {{transmembranereceptor-stub}}