P2RX6

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''P2X purinoceptor 6''' is a [[protein]] that in humans is encoded by the ''P2RX6'' [[gene]].<ref name="pmid9242461">{{cite journal | vauthors = Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T | title = Cloning of P2XM, a novel human P2X receptor gene regulated by p53 | journal = Cancer Res | volume = 57 | issue = 15 | pages = 3281–7 |date=Sep 1997 | pmid = 9242461 }}</ref><ref name="pmid10591208">{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP| title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 |date=Dec 1999 | pmid = 10591208 | doi = 10.1038/990031 | bibcode = 1999Natur.402..489D |display-authors=etal| doi-access = free }}</ref><ref name="pmid8786426">{{cite journal | vauthors = Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G | title = Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels | journal = J Neurosci | volume = 16 | issue = 8 | pages = 2495–507 |date=Sep 1996 | doi = 10.1523/JNEUROSCI.16-08-02495.1996 | pmid = 8786426 | pmc = 6578782 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9127}}</ref>

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.<ref name="entrez">{{cite web | title = Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9127}}</ref>

==See also== * [[Purinergic receptor]]

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Khakh BS, Burnstock G, Kennedy C, etal |title=International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. |journal=Pharmacol. Rev. |volume=53 |issue= 1 |pages= 107–18 |year= 2001 |doi=10.1016/S0031-6997(24)01482-0 |pmid= 11171941 }} *{{cite journal | vauthors=Soto F, Garcia-Guzman M, Karschin C, Stühmer W |title=Cloning and tissue distribution of a novel P2X receptor from rat brain. |journal=Biochem. Biophys. Res. Commun. |volume=223 |issue= 2 |pages= 456–60 |year= 1996 |pmid= 8670303 |doi= 10.1006/bbrc.1996.0915 }} *{{cite journal | vauthors=Glass R, Loesch A, Bodin P, Burnstock G |title=P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells. |journal=Cell. Mol. Life Sci. |volume=59 |issue= 5 |pages= 870–81 |year= 2002 |pmid= 12088286 |doi=10.1007/s00018-002-8474-y |s2cid=16519633 |pmc=11146110 }} *{{cite journal |vauthors=Maguire PB, Wynne KJ, Harney DF, etal |title=Identification of the phosphotyrosine proteome from thrombin activated platelets. |journal=Proteomics |volume=2 |issue= 6 |pages= 642–8 |year= 2003 |pmid= 12112843 |doi= 10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I |s2cid=22665513 |doi-access=free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |doi-access=free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Barrera NP, Ormond SJ, Henderson RM, etal |title=Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10759–65 |year= 2005 |pmid= 15657042 |doi= 10.1074/jbc.M412265200 |doi-access= free }} *{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} {{refend}}

== External links == * {{MeshName|P2RXL1+protein,+human}}

[[Category:Ion channels]]