Owen McCarty

{{Infobox scientist | name = Owen McCarty | alma_mater = University of Buffalo<br> Johns Hopkins University | website = https://www.ohsu.edu/people/owen-jt-mccarty-phd-faha }} '''Owen McCarty''' is an American biomedical engineer who studies the dynamics of the vascular system in the context of cancer metastasis, cardiovascular disease, and inflammation. He is the Douglas Strain Professor and Chair of the Biomedical Engineering Department at Oregon Health & Science University (OHSU) and a fellow of the American Heart Association.<ref>{{Cite web|title=Owen McCarty|url=https://inbt.jhu.edu/psoc/people/owen-mccarthy/|access-date=2022-02-08|language=en-US}}</ref>

== Education and career == McCarty received his B.S. in Chemical Engineering from SUNY-Buffalo. He attended Johns Hopkins University to pursue his Ph.D. with Konstantinos Konstantopoulos and investigate tumor cell receptors for white blood cells and platelets.<ref>{{Cite book|last1=McCarty|first1=O.|last2=Konstantopoulos|first2=K.|title=Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015) |chapter=Molecular mechanisms of platelet-tumor cell adhesion under flow |date=October 1999|chapter-url=https://ieeexplore.ieee.org/document/802096/;jsessionid=DmTbQairDhhfQePOKSKAnlYzbghvyASy4QBEhiWNfYbyT95lEhGa!1229044999|volume=1|pages=61 vol.1–|doi=10.1109/IEMBS.1999.802096|isbn=0-7803-5674-8 |s2cid=86118001 }}</ref> He completed his post-doctoral training under the mentorship of Steve Watson as a Wellcome Trust Fellow in the Pharmacology Department at the University of Oxford and University of Birmingham. In 2005, he accepted a faculty position in the Department of Biomedical Engineering at Oregon Health & Science University. He has served as chair of the Biomedical Engineering Department since 2019 and orchestrated collaborative partnerships with OHSU's School of Medicine, School of Dentistry, and external institutions.

== Current work and achievements == McCarty investigates fluid mechanics and cellular biology of the vasculature with the goal of translating these insights into molecular-targeted therapies. His research program has helped take two drug candidates to clinical trials and has also provided insight on the anti-cancer effects of aspirin.<ref>{{Cite web|date=2016-12-24|title=New study explains how low-dose aspirin may prevent cancer|url=https://www.medicalnewstoday.com/articles/314889|access-date=2022-02-08|website=www.medicalnewstoday.com|language=en}}</ref><ref>{{Cite journal|last1=Mitrugno|first1=Annachiara|last2=Sylman|first2=Joanna L.|last3=Ngo|first3=Anh T. P.|last4=Pang|first4=Jiaqing|last5=Sears|first5=Rosalie C.|last6=Williams|first6=Craig D.|last7=McCarty|first7=Owen J. T.|date=2017-02-01|title=Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC|journal=American Journal of Physiology. Cell Physiology|volume=312|issue=2|pages=C176–C189|doi=10.1152/ajpcell.00196.2016|issn=0363-6143|pmc=5336594|pmid=27903583}}</ref><ref>{{Cite journal |last1=Lorentz |first1=Christina U. |last2=Verbout |first2=Norah G. |last3=Wallisch |first3=Michael |last4=Hagen |first4=Matthew W. |last5=Shatzel |first5=Joseph J. |last6=Olson |first6=Sven R. |last7=Puy |first7=Cristina |last8=Hinds |first8=Monica T. |last9=McCarty |first9=Owen J.T. |last10=Gailani |first10=David |last11=Gruber |first11=András |last12=Tucker |first12=Erik I. |date=2019-04-01 |title=Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial |journal=Arteriosclerosis, Thrombosis, and Vascular Biology |volume=39 |issue=4 |pages=799–809 |doi=10.1161/ATVBAHA.118.312328 |pmc=6494446 |pmid=30700130}}</ref>

== Honors and awards == {{BLP unsourced section|date=March 2022}} * 2002: Howard & Jacqueline Chertkof Endowed Fellowship, Johns Hopkins University * 2003: University Merit Review Award, University of Oxford * 2004 British Journal of Haematology Research Trust Award * 2004: Paper of the Year in the Platelets Section of the Journal of Thrombosis and Haemostasis * 2004: International Society on Thrombosis and Haemostasis Young Investigator Award * 2005: Gordon Research Conference Speaker Award * 2007: Paper of the Year in the Platelets Section of the Journal of Thrombosis and Haemostasis * 2009: American Heart Association Karl Link New Investigator Award in Thrombosis * 2010: American Heart Association Kenneth M. Brinkhous Young Investigator in Thrombosis Finalist * 2013: American Heart Association Established Investigator Award * 2014: Fellow of the American Heart Association * 2019: Best Basic Science Award at the International Sepsis Forum * 2021: Douglas Strain Endowed Professorship, OHSU Department of Biomedical Engineering

== Publications == * '''McCarty, O. J'''., Mousa, S. A., Bray, P. F., & Konstantopoulos, K. (2000). Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions. ''Blood, The Journal of the American Society of Hematology'', ''96''(5), 1789-1797.<ref>{{Cite journal|last1=McCarty|first1=Owen J. T.|last2=Mousa|first2=Shaker A.|last3=Bray|first3=Paul F.|last4=Konstantopoulos|first4=Konstantinos|date=2000-09-01|title=Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions|url=https://doi.org/10.1182/blood.V96.5.1789|journal=Blood|volume=96|issue=5|pages=1789–1797|doi=10.1182/blood.V96.5.1789|pmid=10961878 |issn=0006-4971|url-access=subscription}}</ref> *'''McCarty, O. J'''., Larson, M. K., Auger, J. M., Kalia, N., Atkinson, B. T., Pearce, A. C., ... & Watson, S. P. (2005). Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. ''Journal of biological chemistry'', ''280''(47), 39474-39484.<ref>{{Cite journal|last1=McCarty|first1=Owen J. T.|last2=Larson|first2=Mark K.|last3=Auger|first3=Jocelyn M.|last4=Kalia|first4=Neena|last5=Atkinson|first5=Ben T.|last6=Pearce|first6=Andrew C.|last7=Ruf|first7=Sandra|last8=Henderson|first8=Robert B.|last9=Tybulewicz|first9=Victor L. J.|last10=Machesky|first10=Laura M.|last11=Watson|first11=Steve P.|date=2005-11-25|title=Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow *|journal=Journal of Biological Chemistry|language=English|volume=280|issue=47|pages=39474–39484|doi=10.1074/jbc.M504672200|issn=0021-9258|pmid=16195235|pmc=1395485 |doi-access=free }}</ref> *Cheng, Q., Tucker, E. I., Pine, M. S., Sisler, I., Matafonov, A., Sun, M. F., ... '''McCarty, O. J. T.''', ... & Gailani, D. (2010). A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo. ''Blood, The Journal of the American Society of Hematology'', ''116''(19), 3981-3989.<ref>{{Cite journal|last1=Cheng|first1=Qiufang|last2=Tucker|first2=Erik I.|last3=Pine|first3=Meghann S.|last4=Sisler|first4=India|last5=Matafonov|first5=Anton|last6=Sun|first6=Mao-fu|last7=White-Adams|first7=Tara C.|last8=Smith|first8=Stephanie A.|last9=Hanson|first9=Stephen R.|last10=McCarty|first10=Owen J. T.|last11=Renné|first11=Thomas|date=2010-11-11|title=A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo|url=https://doi.org/10.1182/blood-2010-02-270918|journal=Blood|volume=116|issue=19|pages=3981–3989|doi=10.1182/blood-2010-02-270918|pmid=20634381 |pmc=2981546 |issn=0006-4971}}</ref> *Aslan, J. E., & '''McCarty, O. J.''' (2013). Rho GTPases in platelet function. ''Journal of Thrombosis and Haemostasis'', ''11''(1), 35-46.<ref>{{Cite journal|last1=Aslan|first1=J. E.|last2=Mccarty|first2=O. J. T.|date=2013|title=Rho GTPases in platelet function|journal=Journal of Thrombosis and Haemostasis|language=en|volume=11|issue=1|pages=35–46|doi=10.1111/jth.12051|issn=1538-7836|pmc=3928789|pmid=23121917}}</ref> *Itakura, A., & '''McCarty, O. J.''' (2013). Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy. ''American Journal of Physiology. Cell Physiology'', ''305''(3), C348-C354.<ref>{{Cite journal|last1=Itakura|first1=Asako|last2=McCarty|first2=Owen J. T.|date=2013-08-01|title=Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy|journal=American Journal of Physiology. Cell Physiology|volume=305|issue=3|pages=C348–C354|doi=10.1152/ajpcell.00108.2013|issn=0363-6143|pmc=3742850|pmid=23720022}}</ref>

== References == {{reflist}}

{{DEFAULTSORT:McCarty, Owen}} Category:Living people Category:21st-century American scientists Category:American biomedical engineers Category:Year of birth missing (living people) Category:Oregon Health & Science University faculty