Organification is a biochemical process that takes place in the thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO)[1] Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".[2]

Thionamides can block organification.[3]

References

  1. ^ Shargel L, Mutnick AH, Souney PF (May 2007). Comprehensive Pharmacy Review. Lippincott Williams and Wilkins. p. 1181. ISBN 978-0-7817-7403-1.
  2. ^ Molinam PE, Ashman R. Endocrine Physiology. Third ed. McGraw Hill Professional. p. 81. ISBN 978-0-07-161302-6.
  3. ^ "Thionamides". Meyler's Side Effects of Drugs. Sixteenth ed. Oxford: Elsevier. January 2016. pp. 874–889. doi:10.1016/b978-0-444-53717-1.01537-7. ISBN 978-0-444-53716-4. Retrieved 2021-02-18.