POU2F1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''POU domain, class 2, transcription factor 1''' is a protein that in humans is encoded by the ''POU2F1'' gene.<ref name="pmid1887216">{{cite journal | vauthors = Roberts SB, Segil N, Heintz N | title = Differential phosphorylation of the transcription factor Oct1 during the cell cycle | journal = Science | volume = 253 | issue = 5023 | pages = 1022–6 | date = October 1991 | pmid = 1887216 | doi = 10.1126/science.1887216 | s2cid = 23291453 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5451}}</ref>

== Interactions ==

POU2F1 has been shown to interact with: {{div col|colwidth=20em}} * EPRS,<ref name = pmid9537509>{{cite journal | vauthors = Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T | title = Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase | journal = FEBS Lett. | volume = 424 | issue = 1–2 | pages = 27–32 | date = March 1998 | pmid = 9537509 | doi = 10.1016/s0014-5793(98)00131-8| s2cid = 872132 | doi-access = free | bibcode = 1998FEBSL.424...27N }}</ref> * Glucocorticoid receptor,<ref name = pmid10480874>{{cite journal | vauthors = Préfontaine GG, Walther R, Giffin W, Lemieux ME, Pope L, Haché RJ | title = Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter | journal = J. Biol. Chem. | volume = 274 | issue = 38 | pages = 26713–9 | date = September 1999 | pmid = 10480874 | doi = 10.1074/jbc.274.38.26713| doi-access = free }}</ref><ref name = pmid10490647>{{cite journal | vauthors = Wang JM, Préfontaine GG, Lemieux ME, Pope L, Akimenko MA, Haché RJ | title = Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding | journal = Mol. Cell. Biol. | volume = 19 | issue = 10 | pages = 7106–22 | date = October 1999 | pmid = 10490647 | pmc = 84705 | doi = 10.1128/mcb.19.10.7106}}</ref><ref name = pmid9584182>{{cite journal | vauthors = Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ | title = Recruitment of octamer transcription factors to DNA by glucocorticoid receptor | journal = Mol. Cell. Biol. | volume = 18 | issue = 6 | pages = 3416–30 | date = June 1998 | pmid = 9584182 | pmc = 108923 | doi = 10.1128/mcb.18.6.3416}}</ref> * Glyceraldehyde 3-phosphate dehydrogenase,<ref name = pmid12887926/> * Host cell factor C1,<ref name = pmid9889203>{{cite journal | vauthors = La Boissière S, Hughes T, O'Hare P | title = HCF-dependent nuclear import of VP16 | journal = EMBO J. | volume = 18 | issue = 2 | pages = 480–9 | date = January 1999 | pmid = 9889203 | pmc = 1171141 | doi = 10.1093/emboj/18.2.480 }}</ref><ref name = pmid8454622>{{cite journal | vauthors = Kristie TM, Sharp PA | title = Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) | journal = J. Biol. Chem. | volume = 268 | issue = 9 | pages = 6525–34 | date = March 1993 | doi = 10.1016/S0021-9258(18)53282-8 | pmid = 8454622 | doi-access = free }}</ref> * Ku80,<ref name = pmid11279128>{{cite journal | vauthors = Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ | title = The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 16848–56 | date = May 2001 | pmid = 11279128 | doi = 10.1074/jbc.M100768200 | doi-access = free }}</ref><ref name = pmid12393188>{{cite journal | vauthors = Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M | title = Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication | journal = Biochim. Biophys. Acta | volume = 1578 | issue = 1–3 | pages = 59–72 | date = October 2002 | pmid = 12393188 | doi = 10.1016/s0167-4781(02)00497-9}}</ref> * MNAT1<ref name = pmid9368058>{{cite journal | vauthors = Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG | title = The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors | journal = J. Biol. Chem. | volume = 272 | issue = 47 | pages = 29852–8 | date = November 1997 | pmid = 9368058 | doi = 10.1074/jbc.272.47.29852| doi-access = free }}</ref> * NPAT,<ref name = pmid12887926>{{cite journal | vauthors = McKnight S | title = Gene switching by metabolic enzymes--how did you get on the invitation list? | journal = Cell | volume = 114 | issue = 2 | pages = 150–2 | date = July 2003 | pmid = 12887915 | doi = 10.1016/s0092-8674(03)00563-4| s2cid = 895360 | doi-access = free }}</ref> * Nuclear receptor co-repressor 2,<ref name = pmid11134019>{{cite journal | vauthors = Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K | title = Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor | journal = J. Biol. Chem. | volume = 276 | issue = 13 | pages = 9720–5 | date = March 2001 | pmid = 11134019 | doi = 10.1074/jbc.M008531200 | doi-access = free }}</ref> * POU2AF1,<ref name = pmid9418884/><ref name = pmid10541551>{{cite journal | vauthors = Chasman D, Cepek K, Sharp PA, Pabo CO | title = Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface | journal = Genes Dev. | volume = 13 | issue = 20 | pages = 2650–7 | date = October 1999 | pmid = 10541551 | pmc = 317104 | doi = 10.1101/gad.13.20.2650}}</ref><ref name = pmid11380252>{{cite journal | vauthors = Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B | title = Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator | journal = Biochemistry | volume = 40 | issue = 22 | pages = 6580–8 | date = June 2001 | pmid = 11380252 | doi = 10.1021/bi010095x}}</ref> * RELA,<ref name = pmid12019209>{{cite journal | vauthors = van Heel DA, Udalova IA, De Silva AP, McGovern DP, Kinouchi Y, Hull J, Lench NJ, Cardon LR, Carey AH, Jewell DP, Kwiatkowski D | title = Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors | journal = Hum. Mol. Genet. | volume = 11 | issue = 11 | pages = 1281–9 | date = May 2002 | pmid = 12019209 | doi = 10.1093/hmg/11.11.1281| doi-access = free }}</ref> * Retinoid X receptor alpha,<ref name = pmid10480874/><ref name = pmid10383413>{{cite journal | vauthors = Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, ((Mori Ji)), Kumagai M, Hashizume K | title = Functional interaction between Oct-1 and retinoid X receptor | journal = J. Biol. Chem. | volume = 274 | issue = 27 | pages = 19103–8 | date = July 1999 | pmid = 10383413 | doi = 10.1074/jbc.274.27.19103| doi-access = free }}</ref> * SNAPC4,<ref name = pmid9418884>{{cite journal | vauthors = Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N | title = The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1 | journal = Mol. Cell. Biol. | volume = 18 | issue = 1 | pages = 368–77 | date = January 1998 | pmid = 9418884 | pmc = 121507 | doi = 10.1128/mcb.18.1.368}}</ref><ref name = pmid11856838>{{cite journal | vauthors = Hovde S, Brooks A, Strong K, Geiger JH | title = Crystallization of the Oct-1/SNAP190 peptide/DNA complex | journal = Acta Crystallogr. D | volume = 58 | issue = Pt 3 | pages = 511–2 | date = March 2002 | pmid = 11856838 | doi = 10.1107/s0907444901021461}}</ref> * Sp1 transcription factor,<ref name = pmid8668525>{{cite journal | vauthors = Ström AC, Forsberg M, Lillhager P, Westin G | title = The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression | journal = Nucleic Acids Res. | volume = 24 | issue = 11 | pages = 1981–6 | date = June 1996 | pmid = 8668525 | pmc = 145891 | doi = 10.1093/nar/24.11.1981}}</ref><ref name = pmid10976766>{{cite journal | vauthors = Gunther M, Laithier M, Brison O | title = A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening | journal = Mol. Cell. Biochem. | volume = 210 | issue = 1–2 | pages = 131–42 | date = July 2000 | pmid = 10976766 | doi = 10.1023/A:1007177623283| s2cid = 1339642 }}</ref> and * TATA binding protein.<ref name = pmid8202368>{{cite journal | vauthors = Zwilling S, Annweiler A, Wirth T | title = The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP | journal = Nucleic Acids Res. | volume = 22 | issue = 9 | pages = 1655–62 | date = May 1994 | pmid = 8202368 | pmc = 308045 | doi = 10.1093/nar/22.9.1655}}</ref> {{Div col end}}

== See also == * Octamer transcription factor

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Hsieh CL, Sturm R, Herr W, Francke U | title = The gene for the ubiquitous octamer-binding protein Oct–1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1 | journal = Genomics | volume = 6 | issue = 4 | pages = 666–72 | year = 1990 | pmid = 2341156 | doi = 10.1016/0888-7543(90)90502-L | doi-access = free }} * {{cite journal | vauthors = Sturm RA, Das G, Herr W | title = The ubiquitous octamer-binding protein Oct–1 contains a POU domain with a homeo box subdomain | journal = Genes Dev. | volume = 2 | issue = 12A | pages = 1582–99 | year = 1989 | pmid = 2905684 | doi = 10.1101/gad.2.12a.1582 | doi-access = free }} * {{cite journal | vauthors = Nakshatri H, Nakshatri P, Currie RA | title = Interaction of Oct–1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter | journal = J. Biol. Chem. | volume = 270 | issue = 33 | pages = 19613–23 | year = 1995 | pmid = 7642649 | doi = 10.1074/jbc.270.33.19613 | doi-access = free | hdl = 1805/18867 | hdl-access = free }} * {{cite journal | vauthors = Cox M, van Tilborg PJ, de Laat W, Boelens R, van Leeuwen HC, van der Vliet PC, Kaptein R | title = Solution structure of the Oct–1 POU homeodomain determined by NMR and restrained molecular dynamics | journal = J. Biomol. NMR | volume = 6 | issue = 1 | pages = 23–32 | year = 1995 | pmid = 7663141 | doi = 10.1007/BF00417488 | s2cid = 26063646 }} * {{cite journal | vauthors = Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H | title = In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor | journal = J. Virol. | volume = 67 | issue = 10 | pages = 6224–33 | year = 1993 | doi = 10.1128/JVI.67.10.6224-6233.1993 | pmid = 7690421 | pmc = 238044 }} * {{cite journal | vauthors = Zwilling S, König H, Wirth T | title = High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors | journal = EMBO J. | volume = 14 | issue = 6 | pages = 1198–208 | year = 1995 | pmid = 7720710 | pmc = 398197 | doi = 10.1002/j.1460-2075.1995.tb07103.x}} * {{cite journal | vauthors = Sturm RA, Eyre HJ, Baker E, Sutherland GR |authorlink4=Grant Robert Sutherland | title = The human OTF1 locus which overlaps the CD3Z gene is located at 1q22→q23 | journal = Cytogenet. Cell Genet. | volume = 68 | issue = 3–4 | pages = 231–2 | year = 1995 | pmid = 7842742 | doi = 10.1159/000133919 }} * {{cite journal | vauthors = Klemm JD, Rould MA, Aurora R, Herr W, Pabo CO | title = Crystal structure of the Oct–1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules | journal = Cell | volume = 77 | issue = 1 | pages = 21–32 | year = 1994 | pmid = 8156594 | doi = 10.1016/0092-8674(94)90231-3 | s2cid = 36371069 }} * {{cite journal | vauthors = Zwilling S, Annweiler A, Wirth T | title = The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP | journal = Nucleic Acids Res. | volume = 22 | issue = 9 | pages = 1655–62 | year = 1994 | pmid = 8202368 | pmc = 308045 | doi = 10.1093/nar/22.9.1655 }} * {{cite journal | vauthors = Kristie TM, Sharp PA | title = Purification of the cellular C1 factor required for the stable recognition of the Oct–1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) | journal = J. Biol. Chem. | volume = 268 | issue = 9 | pages = 6525–34 | year = 1993 | doi = 10.1016/S0021-9258(18)53282-8 | pmid = 8454622 | doi-access = free }} * {{cite journal | vauthors = Assa-Munt N, Mortishire-Smith RJ, Aurora R, Herr W, Wright PE | title = The solution structure of the Oct–1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain | journal = Cell | volume = 73 | issue = 1 | pages = 193–205 | year = 1993 | pmid = 8462099 | doi = 10.1016/0092-8674(93)90171-L | s2cid = 24276357 }} * {{cite journal | vauthors = Dekker N, Cox M, Boelens R, Verrijzer CP, van der Vliet PC, Kaptein R | title = Solution structure of the POU-specific DNA-binding domain of Oct–1 | journal = Nature | volume = 362 | issue = 6423 | pages = 852–5 | year = 1993 | pmid = 8479524 | doi = 10.1038/362852a0 | bibcode = 1993Natur.362..852D | s2cid = 21540451 }} * {{cite journal | vauthors = Ström AC, Forsberg M, Lillhager P, Westin G | title = The transcription factors Sp1 and Oct–1 interact physically to regulate human U2 snRNA gene expression | journal = Nucleic Acids Res. | volume = 24 | issue = 11 | pages = 1981–6 | year = 1996 | pmid = 8668525 | pmc = 145891 | doi = 10.1093/nar/24.11.1981 }} * {{cite journal | vauthors = Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG | title = The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors | journal = J. Biol. Chem. | volume = 272 | issue = 47 | pages = 29852–8 | year = 1997 | pmid = 9368058 | doi = 10.1074/jbc.272.47.29852 | doi-access = free }} * {{cite journal | vauthors = Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N | title = The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct–1 | journal = Mol. Cell. Biol. | volume = 18 | issue = 1 | pages = 368–77 | year = 1998 | pmid = 9418884 | pmc = 121507 | doi = 10.1128/mcb.18.1.368}} * {{cite journal | vauthors = Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T | title = Interaction of Oct–1 and automodification domain of poly(ADP-ribose) synthetase | journal = FEBS Lett. | volume = 424 | issue = 1–2 | pages = 27–32 | year = 1998 | pmid = 9537509 | doi = 10.1016/S0014-5793(98)00131-8 | s2cid = 872132 | doi-access = free | bibcode = 1998FEBSL.424...27N }} * {{cite journal | vauthors = Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ | title = Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor | journal = Mol. Cell. Biol. | volume = 18 | issue = 6 | pages = 3416–30 | year = 1998 | pmid = 9584182 | pmc = 108923 | doi = 10.1128/MCB.18.6.3416}} * {{cite journal | vauthors = La Boissière S, Hughes T, O'Hare P | title = HCF-dependent nuclear import of VP16 | journal = EMBO J. | volume = 18 | issue = 2 | pages = 480–9 | year = 1999 | pmid = 9889203 | pmc = 1171141 | doi = 10.1093/emboj/18.2.480 }} {{refend}}

== External links == * {{MeshName|POU2F1+protein,+human}}

Category:POU-domain proteins