| Class | Sirtuin-6 (SIRT6) inhibitor |
|---|---|
| Cas number | 887686-02-4 |
| Chembl | 1588664 |
| Chemspiderid | 4997276 |
| Pubchem | 6496840 |
| Iupac name | 5-[[3-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid |
| C | 19 |
| H | 14 |
| N | 2 |
| O | 6 |
| Smiles | C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O |
| Stdinchi | 1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26) |
| Stdinchikey | HTJWLEGCECXGSQ-UHFFFAOYSA-N |
OSS-128167 is a drug which acts as a sirtuin-6 (SIRT6) inhibitor. It has pro-inflammatory effects and accelerates cellular aging; however, it shows anti-viral and anti-cancer properties which are useful in research, and has also demonstrated potential medical applications for SIRT6 inhibitors such as in the treatment of some forms of asthma.[1][2][3][4][5]
References
- ^ Jiang H, Cheng ST, Ren JH, Ren F, Yu HB, Wang Q, Huang AL, Chen J (2019). "SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors α". Frontiers in Pharmacology. 10. doi:10.3389/fphar.2019.01270. PMC 6823301. PMID 31708789
- ^ Yang J, Li Y, Zhang Y, Fang X, Chen N, Zhou X, Wang X (July 2020). "Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling". Journal of Experimental & Clinical Cancer Research. 39 (1). doi:10.1186/s13046-020-01623-w. PMC 7382040. PMID 32711549
- ^ Huang Y, Zhang J, Xu D, Peng Y, Jin Y, Zhang L (May 2021). "SIRT6‑specific inhibitor OSS‑128167 exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress". Molecular Medicine Reports. 23 (5). doi:10.3892/mmr.2021.12006. PMC 7986000. PMID 33760202
- ^ Zhou H, Liu S, Zhang N, Fang K, Zong J, An Y, Chang X (December 2022). "Downregulation of Sirt6 by CD38 promotes cell senescence and aging". Aging. 14 (23): 9730–9757. doi:10.18632/aging.204425. PMC 9792202. PMID 36490326
- ^ Quan J, Wen X, Su G, Zhong Y, Huang T, Xiong Z, Huang J, Lv Y, Li S, Luo S, Luo C, Cai X, Lai X, Xiang Y, Zheng SG, Shao Y, Lin H, Gao X, Tang J, Lai T (December 2023). "Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling". Nature Communications. 14 (1). Bibcode:2023NatCo..14.8525Q. doi:10.1038/s41467-023-44179-x. PMC 10746710. PMID 38135684