{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Solute carrier organic anion transporter family member 1B3''' (SLCO1B3) also known as '''organic anion-transporting polypeptide 1B3''' (OATP1B3) is a protein that in humans is encoded by the ''SLCO1B3'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=28234}}</ref>

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

== Clinical significance == OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.<ref name="pmid18519758">{{cite journal | vauthors = Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD | title = Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer | journal = Clin. Cancer Res. | volume = 14 | issue = 11 | pages = 3312–8 |date=June 2008 | pmid = 18519758 | pmc = 2701141 | doi = 10.1158/1078-0432.CCR-07-4118 }}</ref> Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.<ref name="pmid21625523">{{cite journal | author = Heather Pressler | author2 = Tristan M. Sissung | author3 = David Venzon| author4 = Douglas K. Price | author5 = William D. Figg | title = Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression| journal = PLOS ONE| volume = 6 | issue = 5 | article-number = e20372 |date=May 2011 | pmid = 21625523 | pmc = 3098289 | doi = 10.1371/journal.pone.0020372| bibcode = 2011PLoSO...620372P | doi-access = free }}</ref>

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.<ref name="pmid21625523" />

==Substrates== Small molecules that are transported by SLCO1B3 include:<ref name="pmid18668430">{{cite journal | vauthors = Hagenbuch B, Gui C | title = Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family | journal = Xenobiotica | volume = 38 | issue = 7–8 | pages = 778–801 |date=July 2008 | pmid = 18668430 | doi = 10.1080/00498250801986951 | s2cid = 85868712 }}</ref> {{div col|colwidth=20em}} * Amanitin * Atrasentan * Bilirubin * Bosentan * BQ-123 * Bromsulphthalein (BSP) * CDCA-NBD * Cholate (CA) * Cholecystokinin octapeptide (CCK-8) * Dehydroepiandroserone-3-sulfate (DHEAS) * Deltorphin II * Demethylphalloin * Digoxin * Docetaxel * [D-penicillamine2,5]enkephalin (DPDPE) * Enalapril * Estradiol-17β-glucuronide 5–25 * Estrone-3-sulfate * Fexofenadine * Fluvastatin * Fluo-3 * Glutathione (GSH) * Glycocholate (GCA) * Glycoursodeoxycholate (GUDCA) * Irinotecan * Leukotriene C4 (LTC4) * Methotrexate * Microcystin * Monoglyucuronosyl * Olmesartan * Ouabain * Paclitaxel * Phalloidin * Pitavastatin * Rifampicin * Ro 48-5033 (Bosentan metabolite) * Rosuvastatin * SN-38 * Taurocholate (TCA) * Taurochenodeoxycholate (TCDCA) * Taurodeoxycholate (TDCA) * Tauroursodeoxycholate (TUDCA) * Telmisartan * Thyroxine (T4) * TR-14035 * Triiodothyronine (T3) * Valsartan {{Div col end}}

==See also== * Solute carrier family

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=König J, Cui Y, Nies AT, Keppler D |title=Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23161–8 |year= 2000 |pmid= 10779507 |doi= 10.1074/jbc.M001448200 |doi-access= free }} *{{cite journal |vauthors=Abe T, Unno M, Onogawa T, etal |title=LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers |journal=Gastroenterology |volume=120 |issue= 7 |pages= 1689–99 |year= 2001 |pmid= 11375950 |doi=10.1053/gast.2001.24804 |doi-access=free }} *{{cite journal |vauthors=Ismair MG, Stieger B, Cattori V, etal |title=Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver |journal=Gastroenterology |volume=121 |issue= 5 |pages= 1185–90 |year= 2001 |pmid= 11677211 |doi=10.1053/gast.2001.28704 |url=http://www.zora.uzh.ch/id/eprint/3000/4/ZORA_3000.pdf }} *{{cite journal |vauthors=Jung D, Podvinec M, Meyer UA, etal |title=Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor |journal=Gastroenterology |volume=122 |issue= 7 |pages= 1954–66 |year= 2002 |pmid= 12055601 |doi=10.1053/gast.2002.33583 |doi-access=free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Cui Y, König J, Nies AT, etal |title=Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma |journal=Lab. Invest. |volume=83 |issue= 4 |pages= 527–38 |year= 2003 |pmid= 12695556 |doi= 10.1097/01.lab.0000065015.02412.48|doi-access=free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Vavricka SR, Jung D, Fried M, etal |title=The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma |journal=J. Hepatol. |volume=40 |issue= 2 |pages= 212–8 |year= 2004 |pmid= 14739090 |doi=10.1016/j.jhep.2003.10.008 }} *{{cite journal | vauthors=Hirano M, Maeda K, Shitara Y, Sugiyama Y |title=Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans |journal=J. Pharmacol. Exp. Ther. |volume=311 |issue= 1 |pages= 139–46 |year= 2004 |pmid= 15159445 |doi= 10.1124/jpet.104.068056 |s2cid=9691203 }} *{{cite journal | vauthors=Letschert K, Keppler D, König J |title=Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8) |journal=Pharmacogenetics |volume=14 |issue= 7 |pages= 441–52 |year= 2005 |pmid= 15226676 |doi=10.1097/01.fpc.0000114744.08559.92 }} *{{cite journal |vauthors=Yamaguchi H, Okada M, Akitaya S, etal |title=Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3 |journal=J. Lipid Res. |volume=47 |issue= 6 |pages= 1196–202 |year= 2006 |pmid= 16534140 |doi= 10.1194/jlr.M500532-JLR200 |s2cid=14682342 |url= http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/50391/3/06_20121105.pdf |doi-access= free }} *{{cite journal |vauthors=Ohtsuka H, Abe T, Onogawa T, etal |title=Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene |journal=J. Gastroenterol. |volume=41 |issue= 4 |pages= 369–77 |year= 2006 |pmid= 16741617 |doi= 10.1007/s00535-006-1784-3 |s2cid=7626543 }} *{{cite journal |vauthors=Briz O, Romero MR, Martinez-Becerra P, etal |title=OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes? |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30326–35 |year= 2006 |pmid= 16877380 |doi= 10.1074/jbc.M602048200 |doi-access= free }} *{{cite journal | vauthors=Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N |title=Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=293 |issue= 1 |pages= G271–8 |year= 2007 |pmid= 17412826 |doi= 10.1152/ajpgi.00075.2007 }} *{{cite journal | vauthors=Treiber A, Schneiter R, Häusler S, Stieger B |title=Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil |journal=Drug Metab. Dispos. |volume=35 |issue= 8 |pages= 1400–7 |year= 2007 |pmid= 17496208 |doi= 10.1124/dmd.106.013615 |s2cid=2625368 }} *{{cite journal |vauthors=Muto M, Onogawa T, Suzuki T, etal |title=Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma |journal=Cancer Sci. |volume=98 |issue= 10 |pages= 1570–6 |year= 2007 |pmid= 17760952 |doi= 10.1111/j.1349-7006.2007.00570.x |s2cid=35010274 |doi-access=free |pmc=11159603 }} {{refend}}

{{Membrane transport proteins}}

Category:Solute carrier family Category: Thyroid hormone transporters

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