Solute carrier organic anion transporter family member 1B1

{{Short description|Protein found in humans}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Solute carrier organic anion transporter family member 1B1''' is a protein that in humans is encoded by the ''SLCO1B1'' gene.<ref name="pmid10358072">{{cite journal | vauthors = Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H | title = Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 | journal = J Biol Chem | volume = 274 | issue = 24 | pages = 17159–63 | date = Jul 1999 | pmid = 10358072 | doi = 10.1074/jbc.274.24.17159 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10599}}</ref> Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.<ref name=art1>{{cite journal | vauthors = Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M | title = SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink | journal = Clinical Pharmacology & Therapeutics | volume = 94 | issue = 6 | pages = 695–701 | year = 2013 | pmid = 23942138 | pmc = 3831180 | doi = 10.1038/clpt.2013.161 }}</ref> Clinical guidelines exist that can guide dosing of simvastatin based on ''SLCO1B1'' gene variant using genotyping or whole exome sequencing.<ref name=art2>{{cite journal | vauthors = Huser V, Cimino JJ | title = Providing pharmacogenomics clinical decision support using whole genome sequencing data as input | journal = AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science | volume = 2013 | pages = 81 | year = 2013 | pmid = 24303303 }}</ref>

==See also== * Solute carrier family

==References== {{reflist}} {{Clear}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors = Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG | title = A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters | journal = J. Biol. Chem. | volume = 274 | issue = 52 | pages = 37161–8 | year = 2000 | pmid = 10601278 | doi = 10.1074/jbc.274.52.37161 | doi-access = free}} *{{cite journal | vauthors = König J, Cui Y, Nies AT, Keppler D | title = A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane | journal = Am. J. Physiol. Gastrointest. Liver Physiol. | volume = 278 | issue = 1 | pages = G156–64 | year = 2000 | pmid = 10644574 | doi = 10.1152/ajpgi.2000.278.1.G156| s2cid = 7358020 | doi-access = free }} *{{cite journal | vauthors = Rollinger-Holzinger I, Eibl B, Pauly M, Griesser U, Hentges F, Auer B, Pall G, Schratzberger P, Niederwieser D, Weiss EH, Zwierzina H | title = LST1: a gene with extensive alternative splicing and immunomodulatory function | journal = J. Immunol. | volume = 164 | issue = 6 | pages = 3169–76 | year = 2000 | pmid = 10706707 | doi = 10.4049/jimmunol.164.6.3169 | doi-access = free }} *{{cite journal | vauthors = König J, Cui Y, Nies AT, Keppler D | title = Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide | journal = J. Biol. Chem. | volume = 275 | issue = 30 | pages = 23161–8 | year = 2000 | pmid = 10779507 | doi = 10.1074/jbc.M001448200 | doi-access = free }} *{{cite journal | vauthors = Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A | title = Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family | journal = Biochem. Biophys. Res. Commun. | volume = 273 | issue = 1 | pages = 251–60 | year = 2000 | pmid = 10873595 | doi = 10.1006/bbrc.2000.2922 }} *{{cite journal | vauthors = Cui Y, König J, Leier I, Buchholz U, Keppler D | title = Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 | journal = J. Biol. Chem. | volume = 276 | issue = 13 | pages = 9626–30 | year = 2001 | pmid = 11134001 | doi = 10.1074/jbc.M004968200 | doi-access = free }} *{{cite journal | vauthors = Tirona RG, Leake BF, Merino G, Kim RB | title = Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans | journal = J. Biol. Chem. | volume = 276 | issue = 38 | pages = 35669–75 | year = 2001 | pmid = 11477075 | doi = 10.1074/jbc.M103792200 | doi-access =free }} *{{cite journal | vauthors = Jung D, Hagenbuch B, Gresh L, Pontoglio M, Meier PJ, Kullak-Ublick GA | title = Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha | journal = J. Biol. Chem. | volume = 276 | issue = 40 | pages = 37206–14 | year = 2001 | pmid = 11483603 | doi = 10.1074/jbc.M103988200 | doi-access = free }} *{{cite journal | vauthors = Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T | title = Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis | journal = J. Pharmacol. Exp. Ther. | volume = 302 | issue = 2 | pages = 804–13 | year = 2002 | pmid = 12130747 | doi = 10.1124/jpet.302.2.804 }} *{{cite journal | vauthors = Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J | title = A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43058–63 | year = 2003 | pmid = 12196548 | doi = 10.1074/jbc.M207735200 | doi-access = free }} *{{cite journal | vauthors = Tirona RG, Leake BF, Wolkoff AW, Kim RB | title = Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation | journal = J. Pharmacol. Exp. Ther. | volume = 304 | issue = 1 | pages = 223–8 | year = 2003 | pmid = 12490595 | doi = 10.1124/jpet.102.043026 | s2cid = 1475068 }} *{{cite journal | vauthors = Wang P, Kim RB, Chowdhury JR, Wolkoff AW | title = The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport | journal = J. Biol. Chem. | volume = 278 | issue = 23 | pages = 20695–9 | year = 2003 | pmid = 12670950 | doi = 10.1074/jbc.M301100200 | doi-access = free }} *{{cite journal | vauthors = Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y | title = Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics | journal = Clin. Pharmacol. Ther. | volume = 73 | issue = 6 | pages = 554–65 | year = 2003 | pmid = 12811365 | doi = 10.1016/S0009-9236(03)00060-2 | s2cid = 6570648 }} *{{cite journal | vauthors = Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C, Backman JT, Kerb R, Schwab M, Neuvonen PJ, Eichelbaum M, Kivistö KT | title = High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1) | journal = Pharmacogenetics | volume = 14 | issue = 7 | pages = 429–40 | year = 2005 | pmid = 15226675 | doi = 10.1097/01.fpc.0000114750.08559.32 }} *{{cite journal | vauthors = Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS | title = Risk factors for severe hyperbilirubinemia in neonates | journal = Pediatr. Res. | volume = 56 | issue = 5 | pages = 682–9 | year = 2005 | pmid = 15319464 | doi = 10.1203/01.PDR.0000141846.37253.AF | doi-access = free }} *{{cite journal | vauthors = Campbell SD, de Morais SM, Xu JJ | title = Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia | journal = Chem. Biol. Interact. | volume = 150 | issue = 2 | pages = 179–87 | year = 2005 | pmid = 15535988 | doi = 10.1016/j.cbi.2004.08.008 }} *{{cite journal | vauthors = Huang CS, Huang MJ, Lin MS, Yang SS, Teng HC, Tang KS | title = Genetic factors related to unconjugated hyperbilirubinemia amongst adults | journal = Pharmacogenet. Genomics | volume = 15 | issue = 1 | pages = 43–50 | year = 2005 | pmid = 15864125 | doi = 10.1097/01213011-200501000-00007 | s2cid = 24247125 }} *{{cite journal | vauthors = Katz DA, Carr R, Grimm DR, Xiong H, Holley-Shanks R, Mueller T, Leake B, Wang Q, Han L, Wang PG, Edeki T, Sahelijo L, Doan T, Allen A, Spear BB, Kim RB | title = Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics | journal = Clin. Pharmacol. Ther. | volume = 79 | issue = 3 | pages = 186–96 | year = 2006 | pmid = 16513443 | doi = 10.1016/j.clpt.2005.11.003 | s2cid = 21496707 }} {{refend}}

Category:Solute carrier family Category: Thyroid hormone transporters