Ninein

{{Short description|Protein in humans and other animals}} {{Infobox_gene}} '''Ninein''' is a [[protein]] that in humans is encoded by the ''NIN'' [[gene]].<ref name="pmid11004522">{{cite journal |vauthors=Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL | title = Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta | journal = Biochim Biophys Acta | volume = 1492 | issue = 2–3 | pages = 513–6 |date=Oct 2000 | pmid = 11004522 | doi = 10.1016/S0167-4781(00)00127-5}}</ref><ref name="pmid11162463">{{cite journal |vauthors=Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL | title = Genomic organization and molecular characterization of the human ninein gene | journal = Biochem. Biophys. Res. Commun. | volume = 279 | issue = 3 | pages = 989–95 |date=Feb 2001 | pmid = 11162463 | doi = 10.1006/bbrc.2000.4050 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NIN ninein (GSK3B interacting protein)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51199}}</ref>

== Function == Ninein, together with its [[paralog]] [[NINL|Ninein-like protein]] is one of the proteins important for [[centrosome|centrosomal]] function. Localization of this protein to the centrosome requires three [[leucine zipper]]s in the central [[coiled-coil]] domain. Multiple [[alternative splicing|alternatively spliced]] transcript variants that encode different [[isoform]]s have been reported.<ref name="entrez" />

This protein is important for positioning and anchoring the [[microtubule]]s minus-ends in [[epithelial cell]]s.<ref name="entrez" />

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | author=Nakajima D |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |name-list-style=vanc| author2=Okazaki N | author3=Yamakawa H | display-authors=3 | last4=Kikuno | first4=R | last5=Ohara | first5=O | last6=Nagase | first6=T | doi-access=free }} *{{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }} *{{cite journal | author=Mack GJ |title=Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome |journal=Arthritis Rheum. |volume=41 |issue= 3 |pages= 551–8 |year= 1998 |pmid= 9506584 |doi= 10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X |name-list-style=vanc| author2=Rees J | author3=Sandblom O | display-authors=3 | last4=Balczon | first4=Ronald | last5=Fritzler | first5=Marvin J. | last6=Rattner | first6=J. B. | doi-access=free}} *{{cite journal | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi= 10.1093/dnares/7.4.271|name-list-style=vanc| author2=Kikuno R | author3=Nakayama M | display-authors=3 | last4=Hirosawa | first4=M | last5=Ohara | first5=O |doi-access=free}} *{{cite journal |vauthors=Ou YY, Mack GJ, Zhang M, Rattner JB |title=CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation |journal=J. Cell Sci. |volume=115 |issue= Pt 9 |pages= 1825–35 |year= 2002 |doi=10.1242/jcs.115.9.1825 |pmid= 11956314 }} *{{cite journal |vauthors=Dammermann A, Merdes A |title=Assembly of centrosomal proteins and microtubule organization depends on PCM-1 |journal=J. Cell Biol. |volume=159 |issue= 2 |pages= 255–66 |year= 2002 |pmid= 12403812 |doi= 10.1083/jcb.200204023 | pmc=2173044 }} *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal | author=Chen CH |title=Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 975–83 |year= 2003 |pmid= 12927815 |doi=10.1016/S0006-291X(03)01510-9 |name-list-style=vanc| author2=Howng SL | author3=Cheng TS | display-authors=3 | last4=Chou | first4=Meng-Hui | last5=Huang | first5=Chi-Ying | last6=Hong | first6=Yi-Ren }} *{{cite journal |vauthors=Fritzler MJ, Zhang M, Stinton LM, Rattner JB |title=Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia |journal=BMC Pediatrics |volume=3|pages= 11 |year= 2004 |pmid= 14503922 |doi= 10.1186/1471-2431-3-11 | pmc=222907 |doi-access=free }} *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }} *{{cite journal | author=Innocenti M |title=Abi1 is essential for the formation and activation of a WAVE2 signalling complex |journal=Nat. Cell Biol. |volume=6 |issue= 4 |pages= 319–27 |year= 2004 |pmid= 15048123 |doi= 10.1038/ncb1105 |name-list-style=vanc| author2=Zucconi A | author3=Disanza A | display-authors=3 | last4=Frittoli | first4=Emanuela | last5=Areces | first5=Liliana B. | last6=Steffen | first6=Anika | last7=Stradal | first7=Theresia E. B. | last8=Fiore | first8=Pier Paolo Di | last9=Carlier | first9=Marie-France |s2cid=22767022 }} *{{cite journal | author=Vizmanos JL |title=NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder |journal=Cancer Res. |volume=64 |issue= 8 |pages= 2673–6 |year= 2004 |pmid= 15087377 |doi=10.1158/0008-5472.CAN-04-0144 |name-list-style=vanc| author2=Novo FJ | author3=Román JP | display-authors=3 | last4=Baxter | first4=EJ | last5=Lahortiga | first5=I | last6=Larráyoz | first6=MJ | last7=Odero | first7=MD | last8=Giraldo | first8=P | last9=Calasanz | first9=MJ | doi-access=free }} *{{cite journal | author=Howng SL |title=A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors |journal=FEBS Lett. |volume=566 |issue= 1–3 |pages= 162–8 |year= 2004 |pmid= 15147888 |doi= 10.1016/j.febslet.2004.04.024 |name-list-style=vanc| author2=Hsu HC | author3=Cheng TS | display-authors=3 | last4=Lee | first4=Yun-Lin | last5=Chang | first5=Li-Kwan | last6=Lu | first6=Pei-Jung | last7=Hong | first7=Yi-Ren | doi-access=free }} *{{cite journal |vauthors=Stillwell EE, Zhou J, Joshi HC |title=Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation |journal=Cell Cycle |volume=3 |issue= 7 |pages= 923–30 |year= 2006 |pmid= 15190203 |doi= 10.4161/cc.3.7.947|doi-access=free }} *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} *{{cite journal |vauthors=Delgehyr N, Sillibourne J, Bornens M |title=Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function |journal=J. Cell Sci. |volume=118 |issue= Pt 8 |pages= 1565–75 |year= 2005 |pmid= 15784680 |doi= 10.1242/jcs.02302 |doi-access= free }} *{{cite journal | author=Cheng TS |title=SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization |journal=Life Sci. |volume=78 |issue= 10 |pages= 1114–20 |year= 2006 |pmid= 16154161 |doi= 10.1016/j.lfs.2005.06.021 |name-list-style=vanc| author2=Chang LK | author3=Howng SL | display-authors=3 | last4=Lu | first4=Pei-Jung | last5=Lee | first5=Chu-I | last6=Hong | first6=Yi-Ren |url=http://ntur.lib.ntu.edu.tw//handle/246246/196401 |url-access=subscription}} {{refend}}

{{Centrosome}}

[[Category:EF-hand-containing proteins]]

{{gene-14-stub}}