Neurotrimin is a protein that in humans is encoded by the NTM gene.[1][2]

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML) on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined.[2]

References

  1. ^ Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL (Apr 1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J Neurosci. 15 (3 Pt 2): 2141–56. doi:10.1523/JNEUROSCI.15-03-02141.1995. PMC 6578143. PMID 7891157
  2. ^ "Entrez Gene: HNT neurotrimin"

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res.. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548
  • Wistow G, Bernstein SL, Wyatt MK, etal (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis.. 8: 205–20. PMID 12107410
  • Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
  • Sellar GC, Watt KP, Rabiasz GJ, etal (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.". Nat. Genet.. 34 (3): 337–43. doi:10.1038/ng1183. PMID 12819783. S2CID 24411276
  • Clark HF, Gurney AL, Abaya E, etal (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res.. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci.. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161
  • Liu J, Li G, Peng X, etal (2004). "The cloning and preliminarily functional analysis of the human neurotrimin gene.". Science in China Series C: Life Sciences. 47 (2): 158–64. doi:10.1360/03yc0072. PMID 15379248. S2CID 12684887
  • Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res.. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334