{{short description|Croatian biochemist|bot=PearBOT 5}} {{Infobox scientist | image = Nenad Ban (Scientist).jpg | image_size = 200px | name = Nenad Ban | birth_date = {{birth date and age|1966|5|3|mf=yes}} | birth_place = Zagreb, Croatia | field = Biochemistry and Biophysics | work_institution = ETH Zurich | alma_mater = University of Zagreb, Croatia, University of California at Riverside | doctoral_advisor = Alexander McPherson | academic_advisors = Thomas A. Steitz | known_for = Structural biology, structure and function of the ribosome, structure and function of multi-enzymes | prizes = Newcomb Cleveland Prize {{small|(2001)}}<br>Rössler Prize {{small|(2009)}}<br>Heinrich Wieland Prize {{small|(2010)}}<br>Ernst Jung Prize {{small|(2017)}}<br>Otto Naegeli Prize {{small|(2018)}} | spouse = Eilika Weber-Ban | footnotes = }} '''Nenad Ban''' is a biochemist born in Zagreb, Croatia who currently works at the ETH Zurich, Swiss Federal Institute of Technology, as a professor of Structural Molecular Biology. He is a pioneer in studying gene expression mechanisms and the participating protein synthesis machinery.
==Career== Nenad Ban was born in 1966 in Zagreb. His parents, Jasna and Zvonimir, were scientists and university professors.<ref name="Jutarnji">{{cite web | url=http://www.jutarnji.hr/genijalni-hrvatski-znanstvenik-kojem-je-za-dlaku-izmakla-nobelova-nagrada-covjek-koji-je-rijesio-jedan-od-najvecih-misterija-molekularne-biologije/1528157/ | title=Genijalnom Hrvatu za dlaku izmakla nobelova nagrada: Upoznajte čovjeka koji je riješio jedan od najvećih misterija molekularne biologije | work=Jutarnji list | date= 26 February 2016 | last=Rudež | first=Tanja | language=hr | accessdate=26 February 2016}}</ref> He received a degree in molecular biology at the Faculty of Science, University of Zagreb and decided to continue with his studies in the United States where he obtained a PhD degree at the University of California, Riverside in the laboratory of Alexander McPherson. He carried out his postdoctoral studies at Yale University in the laboratory of Thomas A. Steitz.
Already in high school he developed an interest in understanding the mechanisms of protein synthesis, which led him to the laboratory of Prof. Zeljko Kucan and Ivana Weygand in Zagreb where he investigated tRNA synthetases, enzymes that charge tRNAs with amino acids to prepare them as substrates for protein synthesis on the ribosome. These interests brought him to the Department of Molecular Biophysics and Biochemistry at Yale University where he determined the atomic structure of the large ribosomal subunit by X-ray crystallography, as part of the group in the laboratory of Thomas A. Steitz. These results demonstrated that the ribosome is a ribozyme.<ref name="Ban Nissen Hansen Moore pp. 905–920">{{cite journal | last1=Ban | first1=Nenad | last2=Nissen | first2=Poul | last3=Hansen | first3=Jeffrey | last4=Moore | first4=Peter B. | last5=Steitz | first5=Thomas A. | title=The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=289 | issue=5481 | date=11 August 2000 | issn=0036-8075 | doi=10.1126/science.289.5481.905 | pages=905–920| pmid=10937989 | bibcode=2000Sci...289..905B }}</ref>
Since 2000 Nenad Ban is a professor of structural molecular biology at the ETH Zurich.<ref>{{cite web |url=https://www.mol.biol.ethz.ch/groups/ban_group/nenad |title=ETH Zurich: Prof. Nenad Ban |publisher=Mol.biol.ethz.ch |date=2013-02-05 |accessdate=2013-09-09 |url-status=dead |archiveurl=https://web.archive.org/web/20130910092029/http://www.mol.biol.ethz.ch/groups/ban_group/nenad |archivedate=2013-09-10 }}</ref> (Swiss Federal Institute of Technology). His group is investigating protein synthesis both in terms of the chemistry of the process and with respect to how it is regulated, how proteins co-translationally fold,<ref name="Ferbitz Maier Patzelt Bukau pp. 590–596">{{cite journal | last1=Ferbitz | first1=Lars | last2=Maier | first2=Timm | last3=Patzelt | first3=Holger | last4=Bukau | first4=Bernd | last5=Deuerling | first5=Elke | last6=Ban | first6=Nenad | title=Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins | journal=Nature | publisher=Springer Science and Business Media LLC | volume=431 | issue=7008 | date=29 August 2004 | issn=0028-0836 | doi=10.1038/nature02899 | pages=590–596| pmid=15334087 | bibcode=2004Natur.431..590F | s2cid=4427021 | url=http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-37064 }}</ref><ref name="Kramer Rauch Rist Vorderwülbecke 2002 pp. 171–174">{{cite journal | last1=Kramer | first1=Günter | last2=Rauch | first2=Thomas | last3=Rist | first3=Wolfgang | last4=Vorderwülbecke | first4=Sonja | last5=Patzelt | first5=Holger | last6=Schulze-Specking | first6=Agnes | last7=Ban | first7=Nenad | last8=Deuerling | first8=Elke | last9=Bukau | first9=Bernd | title=L23 protein functions as a chaperone docking site on the ribosome | journal=Nature | publisher=Springer Science and Business Media LLC | volume=419 | issue=6903 | year=2002 | issn=0028-0836 | doi=10.1038/nature01047 | pages=171–174| pmid=12226666 | bibcode=2002Natur.419..171K | s2cid=2365591 | url=http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-37215 }}</ref> how they are co-translationally modified,<ref name="Bingel-Erlenmeyer Kohler Kramer Sandikci pp. 108–111">{{cite journal | last1=Bingel-Erlenmeyer | first1=Rouven | last2=Kohler | first2=Rebecca | last3=Kramer | first3=Günter | last4=Sandikci | first4=Arzu | last5=Antolić | first5=Snježana | last6=Maier | first6=Timm | last7=Schaffitzel | first7=Christiane | last8=Wiedmann | first8=Brigitte | last9=Bukau | first9=Bernd | last10=Ban | first10=Nenad | title=A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing | journal=Nature | publisher=Springer Science and Business Media LLC | volume=452 | issue=7183 | date=20 February 2008 | issn=0028-0836 | doi=10.1038/nature06683 | pages=108–111| pmid=18288106 | bibcode=2008Natur.452..108B | s2cid=4411842 }}</ref> and how they are targeted to membranes<ref name="Ataide Schmitz Shen Ke pp. 881–886">{{cite journal |last1=Ataide |first1=Sandro F. |last2=Schmitz |first2=Nikolaus |last3=Shen |first3=Kuang |last4=Ke |first4=Ailong |last5=Shan |first5=Shu-ou |last6=Doudna |first6=Jennifer A. |last7=Ban |first7=Nenad |date=18 February 2011 |title=The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor |journal=Science |publisher=American Association for the Advancement of Science (AAAS) |volume=331 |issue=6019 |pages=881–886 |bibcode=2011Sci...331..881A |doi=10.1126/science.1196473 |issn=0036-8075 |pmc=3758919 |pmid=21330537}}</ref> and sorted to different cellular compartments.<ref name="Estrozi Boehringer Shan Ban pp. 88–90">{{cite journal |last1=Estrozi |first1=Leandro F |last2=Boehringer |first2=Daniel |last3=Shan |first3=Shu-ou |last4=Ban |first4=Nenad |last5=Schaffitzel |first5=Christiane |date=12 December 2010 |title=Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor |journal=Nature Structural & Molecular Biology |publisher=Springer Science and Business Media LLC |volume=18 |issue=1 |pages=88–90 |doi=10.1038/nsmb.1952 |issn=1545-9993 |pmc=3764645 |pmid=21151118}}</ref><ref name="Schaffitzel Oswald Berger Ishikawa pp. 503–506">{{cite journal | last1=Schaffitzel | first1=Christiane | last2=Oswald | first2=Miro | last3=Berger | first3=Imre | last4=Ishikawa | first4=Takashi | last5=Abrahams | first5=Jan Pieter | last6=Koerten | first6=Henk K. | last7=Koning | first7=Roman I. | last8=Ban | first8=Nenad | title=Structure of the E. coli signal recognition particle bound to a translating ribosome | journal=Nature | publisher=Springer Science and Business Media LLC | volume=444 | issue=7118 | date=29 October 2006 | issn=0028-0836 | doi=10.1038/nature05182 | pages=503–506| pmid=17086205 | bibcode=2006Natur.444..503S | s2cid=4400092 | hdl=1887/3620885 | hdl-access=free }}</ref><ref>{{Cite journal |last1=Kobayashi |first1=Kan |last2=Jomaa |first2=Ahmad |last3=Lee |first3=Jae Ho |last4=Chandrasekar |first4=Sowmya |last5=Boehringer |first5=Daniel |last6=Shan |first6=Shu-ou |last7=Ban |first7=Nenad |date=2018-04-20 |title=Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex |journal=Science |language=en |volume=360 |issue=6386 |pages=323–327 |doi=10.1126/science.aar7924 |issn=0036-8075 |pmc=6309883 |pmid=29567807}}</ref><ref>{{Cite journal |last1=Jomaa |first1=Ahmad |last2=Gamerdinger |first2=Martin |last3=Hsieh |first3=Hao-Hsuan |last4=Wallisch |first4=Annalena |last5=Chandrasekaran |first5=Viswanathan |last6=Ulusoy |first6=Zeynel |last7=Scaiola |first7=Alain |last8=Hegde |first8=Ramanujan S. |last9=Shan |first9=Shu-ou |last10=Ban |first10=Nenad |last11=Deuerling |first11=Elke |date=2022-02-25 |title=Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting |journal=Science |language=en |volume=375 |issue=6583 |pages=839–844 |doi=10.1126/science.abl6459 |issn=0036-8075 |pmc=7612438 |pmid=35201867}}</ref>
Nenad Ban’s group at ETH Zurich revealed the mechanisms behind the key steps in eukaryotic cytoplasmic and mitochondrial translation with a broad impact on a wide range of fields in biology, chemistry and biomedicine.<ref name="Klinge Voigts-Hoffmann Leibundgut Arpagaus pp. 941–948">{{cite journal | last1=Klinge | first1=Sebastian | last2=Voigts-Hoffmann | first2=Felix | last3=Leibundgut | first3=Marc | last4=Arpagaus | first4=Sofia | last5=Ban | first5=Nenad | title=Crystal Structure of the Eukaryotic 60 S Ribosomal Subunit in Complex with Initiation Factor 6 | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=334 | issue=6058 | date=18 November 2011 | issn=0036-8075 | doi=10.1126/science.1211204 | pages=941–948| pmid=22052974 | bibcode=2011Sci...334..941K | s2cid=206536444 }}</ref><ref name="Rabl Leibundgut Ataide Haag pp. 730–736">{{cite journal | last1=Rabl | first1=Julius | last2=Leibundgut | first2=Marc | last3=Ataide | first3=Sandro F. | last4=Haag | first4=Andrea | last5=Ban | first5=Nenad | title=Crystal Structure of the Eukaryotic 40 S Ribosomal Subunit in Complex with Initiation Factor 1 | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=331 | issue=6018 | date=11 February 2011 | issn=0036-8075 | doi=10.1126/science.1198308 | pages=730–736| pmid=21205638 | bibcode=2011Sci...331..730R | hdl=20.500.11850/153130 | s2cid=24771575 | hdl-access=free }}</ref>
His group also contributed to our understanding of giant multifunctional enzymes involved in fatty acid synthesis offering mechanistic insights into substrate shuttling and delivery in such megasynthases.<ref name="Maier Leibundgut Ban pp. 1315–1322">{{cite journal | last1=Maier | first1=Timm | last2=Leibundgut | first2=Marc | last3=Ban | first3=Nenad | title=The Crystal Structure of a Mammalian Fatty Acid Synthase | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=321 | issue=5894 | date=5 September 2008 | issn=0036-8075 | doi=10.1126/science.1161269 | pages=1315–1322| pmid=18772430 | bibcode=2008Sci...321.1315M | s2cid=3168991 }}</ref><ref name="Leibundgut Jenni Frick Ban pp. 288–290">{{cite journal | last1=Leibundgut | first1=Marc | last2=Jenni | first2=Simon | last3=Frick | first3=Christian | last4=Ban | first4=Nenad | title=Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=316 | issue=5822 | date=13 April 2007 | issn=0036-8075 | doi=10.1126/science.1138249 | pages=288–290| pmid=17431182 | bibcode=2007Sci...316..288L | s2cid=32176226 }}</ref><ref name="Jenni Leibundgut Boehringer Frick pp. 254–261">{{cite journal | last1=Jenni | first1=Simon | last2=Leibundgut | first2=Marc | last3=Boehringer | first3=Daniel | last4=Frick | first4=Christian | last5=Mikolásek | first5=Bohdan | last6=Ban | first6=Nenad | title=Structure of Fungal Fatty Acid Synthase and Implications for Iterative Substrate Shuttling | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=316 | issue=5822 | date=13 April 2007 | issn=0036-8075 | doi=10.1126/science.1138248 | pages=254–261| pmid=17431175 | bibcode=2007Sci...316..254J | s2cid=12820568 }}</ref><ref name="Maier Jenni Ban pp. 1258–1262">{{cite journal | last1=Maier | first1=Timm | last2=Jenni | first2=Simon | last3=Ban | first3=Nenad | title=Architecture of Mammalian Fatty Acid Synthase at 4.5 Å Resolution | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=311 | issue=5765 | date=3 March 2006 | issn=0036-8075 | doi=10.1126/science.1123248 | pages=1258–1262| pmid=16513975 | bibcode=2006Sci...311.1258M | s2cid=39658597 }}</ref><ref name="Jenni Leibundgut Maier Ban pp. 1263–1267">{{cite journal | last1=Jenni | first1=Simon | last2=Leibundgut | first2=Marc | last3=Maier | first3=Timm | last4=Ban | first4=Nenad | title=Architecture of a Fungal Fatty Acid Synthase at 5 Å Resolution | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=311 | issue=5765 | date=3 March 2006 | issn=0036-8075 | doi=10.1126/science.1123251 | pages=1263–1267| pmid=16513976 | bibcode=2006Sci...311.1263J | s2cid=2191407 }}</ref>
==Honors== Nenad Ban is a member of the National Academy of Sciences, the European Molecular Biology Organization (EMBO), the German Academy of Sciences, the Croatian Academy of Arts and Sciences and the recipient of several prizes and awards including the Heinrich Wieland Prize,<ref>{{cite web |url=http://www.heinrich-wieland-preis.de/index/getnews/id/13 |title=Heinrich Wieland Prize |publisher=Heinrich-wieland-preis.de |date=2010-10-28 |accessdate=2013-09-09 |url-status=dead |archiveurl=https://archive.today/20130630232857/http://www.heinrich-wieland-preis.de/index/getnews/id/13 |archivedate=2013-06-30 }}</ref> Rössler Prize of the ETH Zurich,<ref>{{cite web|url=http://www.ethz.ch/media/pressreleases/2009/detail_EN?pr_id=888 |title=ETH Zürich – Archiv 2009 |publisher=Ethz.ch |date= |accessdate=2013-09-09}}</ref> the Latsis prize,<ref name="ETH Zürich 2020">{{cite web | title=Preistragende des Latsis-Preises | website=ETH Zürich | date=30 November 2020 | url=https://ethz.ch/de/forschung/wissenschaftspreise-und-veranstaltungen/latsis-preis/latsis-preistragende.html | language=de | access-date=27 November 2021 | archive-date=27 November 2021 | archive-url=https://web.archive.org/web/20211127115913/https://ethz.ch/de/forschung/wissenschaftspreise-und-veranstaltungen/latsis-preis/latsis-preistragende.html | url-status=dead }}</ref> the Friedrich Miescher Prize of the Swiss Society for Biochemistry,<ref>{{cite web |author=scnat.ch |url=http://www.swissbiochem.ch/FMA/Awardees.php |title=Awardees |publisher=Swissbiochem.ch |date= |accessdate=2013-09-09 |archive-url=https://web.archive.org/web/20131029185313/http://www.swissbiochem.ch/FMA/Awardees.php |archive-date=2013-10-29 |url-status=dead }}</ref> Spiridon Brusina medal, the AAAS Newcomb Cleveland Prize.<ref>{{cite web |url=http://www.aaas.org/aboutaaas/awards/newcomb/newcomb_winners.shtml |title=Newcomb Cleveland Prize – Recipients |publisher=AAAS |date= |accessdate=2013-09-09 |archive-url=https://web.archive.org/web/20121023152927/http://www.aaas.org/aboutaaas/awards/newcomb/newcomb_winners.shtml |archive-date=2012-10-23 |url-status=dead }}</ref> and the Jung Prize.<ref>{{cite web | url=https://www.jung-stiftung.de/en/die-jung-stiftung-1/ernst-jung-preis-fuer-medizin/2017/laureates-2017 | title=Professor Tobias Moser and Professor Nenad Ban | work=jung-stiftung.de | accessdate=2017-01-09 | archive-date=2017-01-10 | archive-url=https://web.archive.org/web/20170110090558/https://www.jung-stiftung.de/en/die-jung-stiftung-1/ernst-jung-preis-fuer-medizin/2017/laureates-2017 | url-status=dead }}</ref>
==Personal life== Ban is married to Eilika Weber, a German scientist whom he met in the United States during his doctoral study. They have two sons, Arvid and Ivo.<ref name="Jutarnji"/>
==References== {{Reflist|30em}}
==External links== *[https://web.archive.org/web/20130412001431/http://www.mol.biol.ethz.ch/groups/ban_group/index Nenad Ban Laboratory Website at ETH Zurich] *[http://www.bangroup.ethz.ch/research/eukaryotic_ribosome.html Resources on Eukaryotic Ribosome Structure] *[https://web.archive.org/web/20160427170630/http://www.bangroup.ethz.ch/research/eukaryotic_translation_initiation.html Resources on Eukaryotic Translation Initiation] *[https://archive.today/20130626181619/http://www.faculty.uci.edu/scripts/UCIFacultyProfiles/fac_detail.CFM?ID=3340 Alexander McPherson Laboratory Website at UC Irvine] *[http://www.yale.edu/steitz/ Thomas Steitz Laboratory Website at Yale] *[http://websrv.leopoldina.org/de/mitglieder/mitgliederverzeichnis/member/1307/ Nenad Ban Leopoldina Profile] {{Webarchive|url=https://web.archive.org/web/20160304065110/http://websrv.leopoldina.org/de/mitglieder/mitgliederverzeichnis/member/1307/ |date=2016-03-04 }}
{{Authority control}}
{{DEFAULTSORT:Ban, Nenad}} Category:Living people Category:1966 births Category:21st-century Croatian scientists Category:Swiss biologists Category:Academic staff of ETH Zurich Category:Faculty of Science, University of Zagreb alumni Category:Yale University alumni Category:Croatian biochemists Category:Croatian expatriates in the United States Category:Croatian expatriates in Switzerland Category:Scientists from Zagreb Category:Foreign associates of the National Academy of Sciences