{{Short description|Combination drug}} {{more citations needed|date=April 2019}} {{Drugbox | image = Estradiol valerate.svg | image_class = skin-invert-image | width = 250px | caption = | image2 = Dienogest.svg | image_class2 = skin-invert-image | width2 = 215px | caption2 = Estradiol valerate (top) and<br />dienogest (bottom)
<!--Combo data--> | type = combo | drug_name = Estradiol valerate / dienogest | component1 = Estradiol valerate | class1 = Estrogen | component2 = Dienogest | class2 = Progestogen
<!-- Clinical data --> | tradename = Lafamme, Natazia, Qlaira | Drugs.com = {{drugs.com|ppa|estradiol-and-dienogest}} | MedlinePlus = a601050 | DailyMedID = Estradiol_and_dienogest | pregnancy_AU = B3 | pregnancy_AU_comment = <ref name="Drugs.com pregnancy">{{cite web | title=Dienogest / estradiol (Natazia) Use During Pregnancy | website=Drugs.com | date=27 January 2020 | url=https://www.drugs.com/pregnancy/dienogest-estradiol.html | access-date=18 March 2020}}</ref> | pregnancy_US = N | pregnancy_US_comment = <ref name="Drugs.com pregnancy" /> | pregnancy_category = Contraindicated<ref name="Drugs.com pregnancy" /> | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM --> <!-- OTC, Rx-only, Schedule I, II, III, IV, V --> | legal_US = Rx-only | routes_of_administration = By mouth | class = Estrogen; Progestogen | ATC_prefix = G03 | ATC_suffix = AB08
<!-- Identifiers --> | CAS_number = 307334-58-3 | PubChem = 9874560 | DrugBank = | KEGG = D10461 | synonyms = EV/DNG; SH T00658ID; Bay 86-5027; BAY86-5027 }}
'''Estradiol valerate/dienogest''' ('''EV/DNG'''), sold under the brand names '''Lafamme''', '''Natazia''' and '''Qlaira''' among others, is a combination product of estradiol valerate, an estrogen, and dienogest, a progestogen, which is used in menopausal hormone therapy in and as a birth control pill to prevent pregnancy in women. It is taken by mouth.
Birth control pills containing EV/DNG are associated with a significantly increased risk of venous thromboembolism.<ref name="pmid30519125">{{cite journal | vauthors = Fruzzetti F, Cagnacci A | title = Venous thrombosis and hormonal contraception: what's new with estradiol-based hormonal contraceptives? | journal = Open Access J Contracept | volume = 9 | pages = 75–79 | date = 2018 | pmid = 30519125 | pmc = 6239102 | doi = 10.2147/OAJC.S179673 | doi-access = free }}</ref> However, they are associated with a significantly lower risk of venous thromboembolism than birth control pills containing ethinylestradiol and a progestin.<ref name="pmid30519125" />
==See also== * Estradiol valerate/cyproterone acetate * Estradiol/nomegestrol acetate * List of combined sex-hormonal preparations
==References== {{Reflist}}
==External links== * {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/estradiol%20valerate%20%252F%20dienogest | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Dienogest mixture with Estradiol valerate }}{{dead link|date=July 2025|bot=medic}}{{cbignore|bot=medic}}
{{Estrogens and antiestrogens}} {{Progestogens and antiprogestogens}} {{Estrogen receptor modulators}} {{Progesterone receptor modulators}} {{Portal bar | Medicine}}
Category:Drugs developed by Bayer Category:Combined estrogen–progestogen formulations
{{Steroid-stub}} {{Genito-urinary-drug-stub}}