NXPH1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Neurexophilin-1''' is a protein that in humans is encoded by the ''NXPH1'' gene.<ref name="pmid9570794">{{cite journal |vauthors=Missler M, Sudhof TC | title = Neurexophilins form a conserved family of neuropeptide-like glycoproteins | journal = J Neurosci | volume = 18 | issue = 10 | pages = 3630–8 |date=Jun 1998 | pmid = 9570794 | pmc = 6793134| doi = 10.1523/JNEUROSCI.18-10-03630.1998| doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NXPH1 neurexophilin 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=30010}}</ref>

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.<ref name="entrez" />

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | author=Ohira M |title=Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma |journal=Cancer Lett. |volume=197 |issue= 1–2 |pages= 63–68 |year= 2003 |pmid= 12880961 |doi=10.1016/S0304-3835(03)00085-5 |name-list-style=vanc| author2=Morohashi A | author3=Nakamura Y | display-authors=3 | last4=Isogai | first4=E | last5=Furuya | first5=K | last6=Hamano | first6=S | last7=Machida | first7=T | last8=Aoyama | first8=M | last9=Fukumura | first9=M }} *{{cite journal | author=Petrenko AG |title=Structure and evolution of neurexophilin |journal=J. Neurosci. |volume=16 |issue= 14 |pages= 4360–9 |year= 1996 |pmid= 8699246 |doi= 10.1523/JNEUROSCI.16-14-04360.1996|name-list-style=vanc| author2=Ullrich B | author3=Missler M | display-authors=3 | last4=Krasnoperov | first4=V | last5=Rosahl | first5=TW | last6=Südhof | first6=TC |pmc=6578849 | doi-access=free}} *{{cite journal |vauthors=Missler M, Hammer RE, Südhof TC |title=Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34716–34723 |year= 1999 |pmid= 9856994 |doi=10.1074/jbc.273.52.34716 |doi-access=free }} *{{cite journal |vauthors=Clarris HJ, McKeown S, Key B |title=Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb |journal=Int. J. Dev. Biol. |volume=46 |issue= 4 |pages= 649–52 |year= 2003 |pmid= 12141453 }} *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal | author=Scherer SW |title=Human chromosome 7: DNA sequence and biology |journal=Science |volume=300 |issue= 5620 |pages= 767–772 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |name-list-style=vanc| author2=Cheung J | author3=MacDonald JR | display-authors=3 | last4=Osborne | first4=LR | last5=Nakabayashi | first5=K | last6=Herbrick | first6=JA | last7=Carson | first7=AR | last8=Parker-Katiraee | first8=L | last9=Skaug | first9=J |bibcode=2003Sci...300..767S }} *{{cite journal | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–164 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |name-list-style=vanc| author2=Fulton RS | author3=Fulton LA | display-authors=3 | last4=Graves | first4=Tina A. | last5=Pepin | first5=Kymberlie H. | last6=Wagner-Mcpherson | first6=Caryn | last7=Layman | first7=Dan | last8=Maas | first8=Jason | last9=Jaeger | first9=Sara |bibcode=2003Natur.424..157H | doi-access=free }} *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }} *{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} {{refend}}