Nucleoporin 54

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Nucleoporin 54''' ('''Nup54''') is a protein that in humans is encoded by the ''NUP54'' gene.<ref name="pmid8707840">{{cite journal | vauthors = Hu T, Guan T, Gerace L | title = Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins | journal = J Cell Biol | volume = 134 | issue = 3 | pages = 589–601 | date = Sep 1996 | pmid = 8707840 | pmc = 2120945 | doi = 10.1083/jcb.134.3.589 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NUP54 nucleoporin 54kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=53371| access-date = }}</ref>

== Function ==

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.<ref name="entrez" />

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Stoffler D, Fahrenkrog B, Aebi U | title = The nuclear pore complex: from molecular architecture to functional dynamics | journal = Curr. Opin. Cell Biol. | volume = 11 | issue = 3 | pages = 391–401 | year = 1999 | pmid = 10395558 | doi = 10.1016/S0955-0674(99)80055-6 }} * {{cite journal | vauthors = Bodoor K, Shaikh S, Enarson P, Chowdhury S, Salina D, Raharjo WH, Burke B | title = Function and assembly of nuclear pore complex proteins | journal = Biochem. Cell Biol. | volume = 77 | issue = 4 | pages = 321–329 | year = 1999 | pmid = 10546895 | doi = 10.1139/bcb-77-4-321 }} * {{cite journal | vauthors = Finlay DR, Meier E, Bradley P, Horecka J, Forbes DJ | title = A complex of nuclear pore proteins required for pore function | journal = J. Cell Biol. | volume = 114 | issue = 1 | pages = 169–183 | year = 1991 | pmid = 2050741 | pmc = 2289063 | doi = 10.1083/jcb.114.1.169 }} * {{cite journal | vauthors = Buss F, Stewart M | title = Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62 | journal = J. Cell Biol. | volume = 128 | issue = 3 | pages = 251–261 | year = 1995 | pmid = 7531196 | pmc = 2120351 | doi = 10.1083/jcb.128.3.251 }} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Guan T, Müller S, Klier G, Panté N, Blevitt JM, Haner M, Paschal B, Aebi U, Gerace L | title = Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex | journal = Mol. Biol. Cell | volume = 6 | issue = 11 | pages = 1591–1603 | year = 1996 | pmid = 8589458 | pmc = 301313 | doi = 10.1091/mbc.6.11.1591 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Popov S, Rexach M, Ratner L, Blobel G, Bukrinsky M | title = Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex | journal = J. Biol. Chem. | volume = 273 | issue = 21 | pages = 13347–13352 | year = 1998 | pmid = 9582382 | doi = 10.1074/jbc.273.21.13347 | doi-access = free }} * {{cite journal | vauthors = Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL | title = Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 17 | pages = 9543–9548 | year = 2000 | pmid = 10931946 | pmc = 16901 | doi = 10.1073/pnas.160270997 | bibcode = 2000PNAS...97.9543H | doi-access = free }} {{refend}}

== External links == * [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q7Z3B4 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Nucleoporin p54

Category:Nuclear pore complex