Nucleoporin 205

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Nucleoporin 205''' ('''Nup205''') is a protein that in humans is encoded by the ''NUP205'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: NUP205 nucleoporin 205kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23165}}</ref><ref name="pmid9039502">{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res. | volume = 3 | issue = 5 | pages = 321–9, 341–54 | date = October 1996 | pmid = 9039502 | doi = 10.1093/dnares/3.5.321 | doi-access = free }}</ref><ref name="pmid9348540">{{cite journal | vauthors = Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E | title = Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly | journal = Mol. Biol. Cell | volume = 8 | issue = 10 | pages = 2017–38 | date = October 1997 | pmid = 9348540 | pmc = 25664 | doi = 10.1091/mbc.8.10.2017 | url = http://www.molbiolcell.org/cgi/content/abstract/8/10/2017 }}</ref>

== Function == Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.<ref name="entrez"/> It has also been recently shown that Nup205 is required for proper viral gene expression.<ref>{{cite journal | vauthors = Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG | date = Nov 2014 | title = Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression | journal = J Virol | volume = 88 | issue = 22| pages = 13249–59 | doi = 10.1128/JVI.00933-14 | pmid = 25210169 | pmc = 4249058 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Hawryluk-Gara LA, Shibuya EK, Wozniak RW | title = Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex | journal = Mol. Biol. Cell | volume = 16 | issue = 5 | pages = 2382–94 | year = 2005 | pmid = 15703211 | pmc = 1087243 | doi = 10.1091/mbc.E04-10-0857 }} * {{cite journal | vauthors = Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E | title = Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly | journal = Mol. Biol. Cell | volume = 8 | issue = 10 | pages = 2017–38 | year = 1997 | pmid = 9348540 | pmc = 25664 | doi = 10.1091/mbc.8.10.2017 }} * {{cite journal | vauthors = Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S | title = Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1 | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45091–8 | year = 2002 | pmid = 12228227 | doi = 10.1074/jbc.M207439200 | doi-access = free }} * {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }} * {{cite journal | vauthors = Hase ME, Cordes VC | title = Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex | journal = Mol. Biol. Cell | volume = 14 | issue = 5 | pages = 1923–40 | year = 2003 | pmid = 12802065 | pmc = 165087 | doi = 10.1091/mbc.E02-09-0620 | hdl = 11858/00-001M-0000-0028-3D33-F }} * {{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res. | volume = 3 | issue = 5 | pages = 321–9, 341–54 | year = 1996 | pmid = 9039502 | doi = 10.1093/dnares/3.5.321 | doi-access = free }} * {{cite journal | vauthors = Sowa ME, Bennett EJ, Gygi SP, Harper JW | title = Defining the human deubiquitinating enzyme interaction landscape | journal = Cell | volume = 138 | issue = 2 | pages = 389–403 | year = 2009 | pmid = 19615732 | pmc = 2716422 | doi = 10.1016/j.cell.2009.04.042 }} * {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }} {{refend}}

Category:Nuclear pore complex