{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Nucleoporin 153''' ('''Nup153''') is a protein which in humans is encoded by the ''NUP153'' gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and is required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin.<ref name="Moroianu1">{{cite journal |vauthors=Moroianu J, Blobel G, Radu A |title=RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9699–704 |year= 1997 |pmid= 9275187 |doi=10.1073/pnas.94.18.9699 | pmc=23253 |bibcode=1997PNAS...94.9699M |doi-access=free }}</ref> On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.
== Background == {{main|Nuclear pore}} Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG.
== Structure == Nucleoporin 153 has a mass of 153 kDA (hence its name). It is filamentous, and it contains three distinct domains: an N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats.<ref name="entrez">{{cite web | title = Entrez Gene: NUP153 nucleoporin 153kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9972}}</ref>
==Interactions== NUP153 has been shown to interact with SENP2<ref name=pmid11896061>{{cite journal |last=Hang |first=Jun |author2=Dasso Mary |date=May 2002|title=Association of the human SUMO-1 protease SENP2 with the nuclear pore |journal=J. Biol. Chem. |volume=277 |issue=22 |pages=19961–6 | issn = 0021-9258| pmid = 11896061 |doi = 10.1074/jbc.M201799200 |doi-access=free }}</ref><ref name=pmid12192048>{{cite journal |last=Zhang |first=Hong |author2=Saitoh Hisato |author3=Matunis Michael J |date=September 2002|title=Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex |journal=Mol. Cell. Biol. |volume=22 |issue=18 |pages=6498–508 | issn = 0270-7306| pmid = 12192048 |doi=10.1128/MCB.22.18.6498-6508.2002 |pmc=135644 }}</ref> and KPNB1.<ref name=pmid10202161>{{cite journal |last=Nakielny |first=S |author2=Shaikh S |author3=Burke B |author4=Dreyfuss G |date=April 1999|title=Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain |journal=EMBO J. |volume=18 |issue=7 |pages=1982–95 | issn = 0261-4189| pmid = 10202161 |doi = 10.1093/emboj/18.7.1982 |pmc=1171283 }}</ref><ref name=pmid10749866>{{cite journal |last=Kehlenbach |first=R H |author2=Gerace L |date=June 2000|title=Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro |journal=J. Biol. Chem. |volume=275 |issue=23 |pages=17848–56 | issn = 0021-9258| pmid = 10749866 |doi = 10.1074/jbc.M001455200 |doi-access=free }}</ref><ref name=pmid11266456>{{cite journal |last=Ben-Efraim |first=I |author2=Gerace L |date=January 2001|title=Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import |journal=J. Cell Biol. |volume=152 |issue=2 |pages=411–7 | issn = 0021-9525| pmid = 11266456 |doi=10.1083/jcb.152.2.411 |pmc=2199621 }}</ref>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal | author=Moroianu J |title=Nuclear import and export pathways. |journal=J. Cell. Biochem. |volume=Suppl 32-33 |pages= 76–83 |year= 2000 |issue=S32 |pmid= 10629106 |doi=10.1002/(SICI)1097-4644(1999)75:32+<76::AID-JCB10>3.0.CO;2-Q |s2cid=45613755 }} *{{cite journal | author=Adam SA |title=The nuclear pore complex. |journal=Genome Biol. |volume=2 |issue= 9 |article-number= REVIEWS0007 |year= 2002 |pmid= 11574060 |doi= 10.1186/gb-2001-2-9-reviews0007 | pmc=138961 |doi-access=free }} *{{cite journal |vauthors=McMorrow I, Bastos R, Horton H, Burke B |title=Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153. |journal=Biochim. Biophys. Acta |volume=1217 |issue= 2 |pages= 219–23 |year= 1994 |pmid= 8110839 |doi= 10.1016/0167-4781(94)90040-X}} *{{cite journal |vauthors=Yaseen NR, Blobel G |title=Cloning and characterization of human karyopherin beta3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4451–6 |year= 1997 |pmid= 9114010 |doi=10.1073/pnas.94.9.4451 | pmc=20743 |bibcode=1997PNAS...94.4451Y |doi-access=free }} *{{cite journal |vauthors=Zolotukhin AS, Felber BK |title=Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. |journal=J. Virol. |volume=73 |issue= 1 |pages= 120–7 |year= 1999 |pmid= 9847314 |doi= 10.1128/JVI.73.1.120-127.1999| pmc=103815 }} *{{cite journal |vauthors=Ullman KS, Shah S, Powers MA, Forbes DJ |title=The nucleoporin nup153 plays a critical role in multiple types of nuclear export. |journal=Mol. Biol. Cell |volume=10 |issue= 3 |pages= 649–64 |year= 1999 |pmid= 10069809 |doi= 10.1091/mbc.10.3.649| pmc=25193 }} *{{cite journal |vauthors=Nakielny S, Shaikh S, Burke B, Dreyfuss G |title=Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1982–95 |year= 1999 |pmid= 10202161 |doi= 10.1093/emboj/18.7.1982 | pmc=1171283 }} *{{cite journal |vauthors=Bachi A, Braun IC, Rodrigues JP, etal |title=The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. |journal=RNA |volume=6 |issue= 1 |pages= 136–58 |year= 2000 |pmid= 10668806 |doi=10.1017/S1355838200991994 | pmc=1369901 }} *{{cite journal |vauthors=Kehlenbach RH, Gerace L |title=Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17848–56 |year= 2000 |pmid= 10749866 |doi= 10.1074/jbc.M001455200 |doi-access= free }} *{{cite journal |vauthors=Kutay U, Hartmann E, Treichel N, etal |title=Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40163–8 |year= 2001 |pmid= 11024021 |doi= 10.1074/jbc.M006242200 |doi-access= free |hdl= 11858/00-001M-0000-0015-3D4E-B |hdl-access= free }} *{{cite journal |vauthors=Herold A, Suyama M, Rodrigues JP, etal |title=TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8996–9008 |year= 2000 |pmid= 11073998 |doi=10.1128/MCB.20.23.8996-9008.2000 | pmc=86553 }} *{{cite journal |vauthors=Hofmann W, Reichart B, Ewald A, etal |title=Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin. |journal=J. Cell Biol. |volume=152 |issue= 5 |pages= 895–910 |year= 2001 |pmid= 11238447 |doi=10.1083/jcb.152.5.895 | pmc=2198816 }} *{{cite journal |vauthors=Ben-Efraim I, Gerace L |title=Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. |journal=J. Cell Biol. |volume=152 |issue= 2 |pages= 411–7 |year= 2001 |pmid= 11266456 |doi=10.1083/jcb.152.2.411 | pmc=2199621 }} *{{cite journal |vauthors=Dimaano C, Ball JR, Prunuske AJ, Ullman KS |title=RNA association defines a functionally conserved domain in the nuclear pore protein Nup153. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45349–57 |year= 2002 |pmid= 11567018 |doi= 10.1074/jbc.M102592200 |doi-access= free }} *{{cite journal |vauthors=Walther TC, Fornerod M, Pickersgill H, etal |title=The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. |journal=EMBO J. |volume=20 |issue= 20 |pages= 5703–14 |year= 2001 |pmid= 11598013 |doi= 10.1093/emboj/20.20.5703 | pmc=125666 }} *{{cite journal |vauthors=Brownawell AM, Macara IG |title=Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. |journal=J. Cell Biol. |volume=156 |issue= 1 |pages= 53–64 |year= 2002 |pmid= 11777942 |doi= 10.1083/jcb.200110082 | pmc=2173575 }} *{{cite journal |vauthors=Hang J, Dasso M |title=Association of the human SUMO-1 protease SENP2 with the nuclear pore. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19961–6 |year= 2002 |pmid= 11896061 |doi= 10.1074/jbc.M201799200 |doi-access= free }} {{refend}} {{PDB Gallery|geneid=9972}}
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Category:Nuclear pore complex