{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Neuropilin 2''' ('''NRP2''') is a protein that in humans is encoded by the ''NRP2'' gene.<ref name="pmid9529250">{{cite journal | vauthors = Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M | title = Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor | journal = Cell | volume = 92 | issue = 6 | pages = 735–45 | date = March 1998 | pmid = 9529250 | doi = 10.1016/S0092-8674(00)81402-6 | s2cid = 547080 | doi-access = free }}</ref><ref name="pmid9331348">{{cite journal | vauthors = Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M | title = Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III | journal = Neuron | volume = 19 | issue = 3 | pages = 547–59 | date = September 1997 | pmid = 9331348 | doi = 10.1016/S0896-6273(00)80371-2 | s2cid = 17985062 | doi-access = free }}</ref>
This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease.<ref>{{Cite journal|last1=Harman|first1=Jennifer L.|last2=Sayers|first2=Jacob|last3=Chapman|first3=Chey|last4=Pellet-Many|first4=Caroline | name-list-style = vanc |date=2020-07-21|title=Emerging Roles for Neuropilin-2 in Cardiovascular Disease |journal=International Journal of Molecular Sciences |volume=21|issue=14|pages=5154|doi=10.3390/ijms21145154|pmid=32708258|pmc=7404143|doi-access=free}}</ref><ref>{{cite journal | vauthors = Kofler N, Simons M | title = The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature | journal = Current Opinion in Hematology | volume = 23 | issue = 3 | pages = 260–7 | date = May 2016 | pmid = 26849476 | pmc = 4957701 | doi = 10.1097/MOH.0000000000000233 }}</ref><ref>{{cite journal | vauthors = Peng K, Bai Y, Zhu Q, Hu B, Xu Y | title = Targeting VEGF-neuropilin interactions: a promising antitumor strategy | journal = Drug Discovery Today | volume = 24 | issue = 2 | pages = 656–664 | date = February 2019 | pmid = 30315890 | doi = 10.1016/j.drudis.2018.10.004 | s2cid = 52979538 }}</ref><ref name="pmid9390514">{{cite journal | vauthors = Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H | title = Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice | journal = Neuron | volume = 19 | issue = 5 | pages = 995–1005 | date = November 1997 | pmid = 9390514 | doi = 10.1016/s0896-6273(00)80392-x | s2cid = 17769318 | doi-access = free }}</ref> Multiple transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NRP2 neuropilin 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8828}}</ref>
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z | title = Vascular endothelial growth factor (VEGF) and its receptors | journal = FASEB Journal | volume = 13 | issue = 1 | pages = 9–22 | date = January 1999 | pmid = 9872925 | doi = 10.1096/fasebj.13.1.9| doi-access = free | s2cid = 1151216 }} * {{cite journal | vauthors = Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD | title = Neuropilin is a semaphorin III receptor | journal = Cell | volume = 90 | issue = 4 | pages = 753–62 | date = August 1997 | pmid = 9288754 | doi = 10.1016/S0092-8674(00)80535-8 | s2cid = 17268123 | doi-access = free }} * {{cite journal | vauthors = Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL | title = Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity | journal = Neuron | volume = 21 | issue = 5 | pages = 1079–92 | date = November 1998 | pmid = 9856463 | doi = 10.1016/S0896-6273(00)80625-X | s2cid = 18445456 | doi-access = free }} * {{cite journal | vauthors = Chen H, He Z, Bagri A, Tessier-Lavigne M | title = Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins | journal = Neuron | volume = 21 | issue = 6 | pages = 1283–90 | date = December 1998 | pmid = 9883722 | doi = 10.1016/S0896-6273(00)80648-0 | doi-access = free }} * {{cite journal | vauthors = Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM | title = Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors | journal = Nature Neuroscience | volume = 1 | issue = 6 | pages = 487–93 | date = October 1998 | pmid = 10196546 | doi = 10.1038/2203 | s2cid = 38320889 }} * {{cite journal | vauthors = Rossignol M, Beggs AH, Pierce EA, Klagsbrun M | title = Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively | journal = Genomics | volume = 57 | issue = 3 | pages = 459–60 | date = May 1999 | pmid = 10329017 | doi = 10.1006/geno.1999.5790 }} * {{cite journal | vauthors = Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM | display-authors = 6 | title = Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates | journal = Cell | volume = 99 | issue = 1 | pages = 71–80 | date = October 1999 | pmid = 10520995 | doi = 10.1016/S0092-8674(00)80063-X | s2cid = 17386412 | doi-access = free }} * {{cite journal | vauthors = Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G | title = Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected] | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18040–5 | date = June 2000 | pmid = 10748121 | doi = 10.1074/jbc.M909259199 | doi-access = free }} * {{cite journal | vauthors = Handa A, Tokunaga T, Tsuchida T, Lee YH, Kijima H, Yamazaki H, Ueyama Y, Fukuda H, Nakamura M | display-authors = 6 | title = Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma | journal = International Journal of Oncology | volume = 17 | issue = 2 | pages = 291–5 | date = August 2000 | pmid = 10891538 | doi = 10.3892/ijo.17.2.291 }} * {{cite journal | vauthors = Rossignol M, Gagnon ML, Klagsbrun M | title = Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms | journal = Genomics | volume = 70 | issue = 2 | pages = 211–22 | date = December 2000 | pmid = 11112349 | doi = 10.1006/geno.2000.6381 }} * {{cite journal | vauthors = Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G | title = Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18688–94 | date = June 2001 | pmid = 11278319 | doi = 10.1074/jbc.M006909200 | doi-access = free }} * {{cite journal | vauthors = Cohen T, Gluzman-Poltorak Z, Brodzky A, Meytal V, Sabo E, Misselevich I, Hassoun M, Boss JH, Resnick M, Shneyvas D, Eldar S, Neufeld G | display-authors = 6 | title = Neuroendocrine cells along the digestive tract express neuropilin-2 | journal = Biochemical and Biophysical Research Communications | volume = 284 | issue = 2 | pages = 395–403 | date = June 2001 | pmid = 11394892 | doi = 10.1006/bbrc.2001.4958 }} * {{cite journal | vauthors = Herzog Y, Kalcheim C, Kahane N, Reshef R, Neufeld G | title = Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins | journal = Mechanisms of Development | volume = 109 | issue = 1 | pages = 115–9 | date = November 2001 | pmid = 11677062 | doi = 10.1016/S0925-4773(01)00518-4 | s2cid = 18341197 | doi-access = }} * {{cite journal | vauthors = Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A, Honda Y | title = Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 1 | pages = 383–8 | date = January 2002 | pmid = 11756651 | pmc = 117569 | doi = 10.1073/pnas.012074399 | bibcode = 2002PNAS...99..383O | doi-access = free }} * {{cite journal | vauthors = Fakhari M, Pullirsch D, Abraham D, Paya K, Hofbauer R, Holzfeind P, Hofmann M, Aharinejad S | display-authors = 6 | title = Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma | journal = Cancer | volume = 94 | issue = 1 | pages = 258–63 | date = January 2002 | pmid = 11815985 | doi = 10.1002/cncr.10177 | s2cid = 45773136 | doi-access = free }} * {{cite journal | vauthors = Cohen T, Herzog Y, Brodzky A, Greenson JK, Eldar S, Gluzman-Poltorak Z, Neufeld G, Resnick MB | display-authors = 6 | title = Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours | journal = The Journal of Pathology | volume = 198 | issue = 1 | pages = 77–82 | date = September 2002 | pmid = 12210066 | doi = 10.1002/path.1179 | s2cid = 24579823 | doi-access = free }} * {{cite journal | vauthors = Kawakami T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Abe Y, Osamura Y, Inoue H, Ueyama Y, Nakamura M | display-authors = 6 | title = Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma | journal = Cancer | volume = 95 | issue = 10 | pages = 2196–201 | date = November 2002 | pmid = 12412174 | doi = 10.1002/cncr.10936 | s2cid = 28744286 | doi-access = }} {{refend}}
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