{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Nardilysin''' is a protein that in humans is encoded by the ''NRD1'' gene.<ref name="pmid9581555">{{cite journal |vauthors=Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P | title = Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family | journal = Biochem J | volume = 327 | issue = 3| pages = 773–9 |date=May 1998 | doi = 10.1042/bj3270773 | pmid = 9581555 | pmc = 1218856 }}</ref><ref name="pmid9479496">{{cite journal |vauthors=Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R | title = Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues | journal = Genomics | volume = 47 | issue = 2 | pages = 238–45 |date=Apr 1998 | pmid = 9479496 | doi = 10.1006/geno.1997.5078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4898}}</ref>
==Interactions== NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.<ref name=pmid11432822>{{cite journal |last=Nishi |first=E |author2=Prat A |author3=Hospital V |author4=Elenius K |author5=Klagsbrun M |date=Jul 2001 |title=N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration |journal=EMBO J. |volume=20 |issue=13 |pages=3342–50 |location = England| issn = 0261-4189| pmid = 11432822 |doi = 10.1093/emboj/20.13.3342 |pmc=125525 }}</ref>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Seidah NG, Prat A |title=Precursor convertases in the secretory pathway, cytosol and extracellular milieu. |journal=Essays Biochem. |volume=38 |pages= 79–94 |year= 2003 |pmid= 12463163 |doi= 10.1042/bse0380079}} *{{cite journal |vauthors=Hospital V, Prat A |title=Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation. |journal=Protein Pept. Lett. |volume=11 |issue= 5 |pages= 501–8 |year= 2005 |pmid= 15544571 |doi=10.2174/0929866043406508 }} *{{cite journal |vauthors=Winter AG, Pierotti AR |title=Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines. |journal=Biochem. J. |volume=351 |issue= 3|pages= 755–64 |year= 2001 |pmid= 11042131 |doi= 10.1042/0264-6021:3510755| pmc=1221416 }} *{{cite journal |vauthors=Nishi E, Prat A, Hospital V, etal |title=N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. |journal=EMBO J. |volume=20 |issue= 13 |pages= 3342–50 |year= 2001 |pmid= 11432822 |doi= 10.1093/emboj/20.13.3342 | pmc=125525 }} *{{cite journal |vauthors=Ma Z, Csuhai E, Chow KM, Hersh LB |title=Expression of the acidic stretch of nardilysin as a functional binding domain. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9447–52 |year= 2001 |pmid= 11478915 |doi=10.1021/bi010538x }} *{{cite journal |vauthors=Hospital V, Nishi E, Klagsbrun M, etal |title=The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). |journal=Biochem. J. |volume=367 |issue= Pt 1 |pages= 229–38 |year= 2003 |pmid= 12095415 |doi= 10.1042/BJ20020822 | pmc=1222870 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Chow KM, Oakley O, Goodman J, etal |title=Nardilysin cleaves peptides at monobasic sites. |journal=Biochemistry |volume=42 |issue= 7 |pages= 2239–44 |year= 2003 |pmid= 12590613 |doi= 10.1021/bi027178d }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} *{{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access=free }} *{{cite journal |vauthors=Nishi E, Hiraoka Y, Yoshida K, etal |title=Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 31164–72 |year= 2006 |pmid= 16923819 |doi= 10.1074/jbc.M601316200 |doi-access= free }} *{{cite journal |vauthors=Bernstein HG, Stricker R, Dobrowolny H, etal |title=Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons. |journal=Neuroscience |volume=146 |issue= 4 |pages= 1513–23 |year= 2007 |pmid= 17442499 |doi= 10.1016/j.neuroscience.2007.02.057 |s2cid=8060302 }} {{refend}}
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