{{Short description|Protein family}} {{infobox protein | Name = neuropeptide Y receptor Y1 | caption = | image = | width = | HGNCid = 7956 | Symbol = NPY1R | AltSymbols = NPYR | EntrezGene = 4886 | OMIM = 162641 | RefSeq = NM_000909 | UniProt = P25929 | PDB = | ECnumber = | Chromosome = 4 | Arm = q | Band = 31.3 | LocusSupplementaryData = -q32 }} {{infobox protein | Name = neuropeptide Y receptor Y2 | caption = | image = | width = | HGNCid = 7957 | Symbol = NPY2R | AltSymbols = | EntrezGene = 4887 | OMIM = 162642 | RefSeq = NM_000910 | UniProt = P49146 | PDB = | ECnumber = | Chromosome = 4 | Arm = q | Band = 31 | LocusSupplementaryData = }} {{infobox protein | Name = pancreatic polypeptide receptor 1 | caption = | image = | width = | HGNCid = 9329 | Symbol = PPYR1 | AltSymbols = NPY4R, Y4, PP1 | EntrezGene = 5540 | OMIM = 601790 | RefSeq = NM_005972 | UniProt = P50391 | PDB = | ECnumber = | Chromosome = 10 | Arm = q | Band = 11.2 | LocusSupplementaryData = }} {{infobox protein | Name = neuropeptide Y receptor Y5 | caption = | image = | width = | HGNCid = 7958 | Symbol = NPY5R | AltSymbols = | EntrezGene = 4889 | OMIM = 602001 | RefSeq = NM_006174 | UniProt = Q15761 | PDB = | ECnumber = | Chromosome = 4 | Arm = q | Band = 31 | LocusSupplementaryData = -q32 }} '''Neuropeptide Y receptors''' are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.<ref name="pmid9549761">{{cite journal | vauthors = Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T | title = XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors | journal = Pharmacol. Rev. | volume = 50 | issue = 1 | pages = 143–50 | date = March 1998 | pmid = 9549761 | url = http://pharmrev.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9549761 | url-status = dead }}</ref> These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.<ref name="pmid15337373">{{cite journal | author = Heilig M | title = The NPY system in stress, anxiety and depression | journal = Neuropeptides | volume = 38 | issue = 4 | pages = 213–24 |date=August 2004 | pmid = 15337373 | doi = 10.1016/j.npep.2004.05.002 | s2cid = 37034137 }}</ref><ref name="pmid16738800">{{cite journal | author = Harro J | title = CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies | journal = Amino Acids | volume = 31 | issue = 3 | pages = 215–30 |date=October 2006 | pmid = 16738800 | doi = 10.1007/s00726-006-0334-x | s2cid = 2017793 }}</ref><ref name="pmid17979774">{{cite journal |vauthors=Eaton K, Sallee FR, Sah R | title = Relevance of neuropeptide Y (NPY) in psychiatry | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1645–59 | year = 2007 | pmid = 17979774 | doi = 10.2174/156802607782341037 }}</ref><ref name="pmid18221213">{{cite journal |vauthors=Xapelli S, Agasse F, Ferreira R, Silva AP, Malva JO | title = Neuropeptide Y as an endogenous antiepileptic, neuroprotective and pro-neurogenic peptide | journal = Recent Patents on CNS Drug Discovery | volume = 1 | issue = 3 | pages = 315–24 |date=November 2006 | pmid = 18221213 | doi = 10.2174/157488906778773689 }}</ref><ref name="pmid17979780">{{cite journal |vauthors=Vona-Davis LC, McFadden DW | title = NPY family of hormones: clinical relevance and potential use in gastrointestinal disease | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1710–20 | year = 2007 | pmid = 17979780 | doi = 10.2174/156802607782340966 }}</ref><ref name="pmid18725086">{{cite journal |vauthors=Lindner D, Stichel J, Beck-Sickinger AG | title = Molecular recognition of the NPY hormone family by their receptors | journal = Nutrition (Burbank, Los Angeles County, Calif.) | volume = 24 | issue = 9 | pages = 907–17 |date=September 2008 | pmid = 18725086 | doi = 10.1016/j.nut.2008.06.025 }}</ref>
Activated neuropeptide receptors release the G<sub>i</sub> subunit from the heterotrimeric G protein complex. The G<sub>i</sub> subunit in turn inhibits the production of the second messenger cAMP from ATP.
Only the crystal structure of Y1 in complex with two antagonist is available.<ref>{{cite journal | vauthors = Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B | title = 1 receptor | journal = Nature | volume = 556 | issue = 7702 | pages = 520–524 | date = April 2018 | pmid = 29670288 | pmc = 5920736 | doi = 10.1038/s41586-018-0046-x }}</ref>
==Types== There are five known mammalian neuropeptide Y receptors designated Y<sub>1</sub> through Y<sub>5</sub>.<ref name="pmid15337367">{{cite journal |vauthors=Larhammar D, Salaneck E | title = Molecular evolution of NPY receptor subtypes | journal = Neuropeptides | volume = 38 | issue = 4 | pages = 141–51 | year = 2004 | pmid = 15337367 | doi = 10.1016/j.npep.2004.06.002 | s2cid = 43696257 }}</ref> Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.<ref name="pmid17785427">{{cite journal |vauthors=Kamiji MM, Inui A | title = Neuropeptide y receptor selective ligands in the treatment of obesity | journal = Endocrine Reviews | volume = 28 | issue = 6 | pages = 664–84 |date=October 2007 | pmid = 17785427 | doi = 10.1210/er.2007-0003 | doi-access = free }}</ref><ref name="pmid17979781">{{cite journal | author = MacNeil DJ | title = NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1721–33 | year = 2007 | pmid = 17979781 | doi = 10.2174/156802607782341028 }}</ref><ref name="pmid17979782">{{cite journal |vauthors=Kamiji MM, Inui A | title = NPY Y2 and Y4 receptors selective ligands: promising anti-obesity drugs? | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1734–42 | year = 2007 | pmid = 17979782 | doi = 10.2174/156802607782340957 }}</ref> * Y<sub>1</sub> - {{Gene|NPY1R}} * Y<sub>2</sub> - {{Gene|NPY2R}} * Y<sub>4</sub> - {{Gene|PPYR1}} * Y<sub>5</sub> - {{Gene|NPY5R}}
==Antagonists==
*BIBP-3226 *Lu AA-33810 *BIIE-0246 *UR-AK49
==References== {{Reflist|2}}
==External links== *{{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1292 | title = Neuropeptide Y Receptors | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2007-10-25 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303193341/http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1292 | url-status = dead }} * {{MeshName|Neuropeptide+Y+Receptor}}
{{G protein-coupled receptors}} {{Neuropeptide receptors}}
Category:G protein-coupled receptors
{{transmembranereceptor-stub}}