{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Neuronal pentraxin-1''' (NP1) is a protein that in humans is encoded by the '''''NPTX1''''' gene.<ref name="pmid8884281">{{cite journal |vauthors=Omeis IA, Hsu YC, Perin MS | title = Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization | journal = Genomics | volume = 36 | issue = 3 | pages = 543–5 |date=September 1996 | pmid = 8884281 | doi = 10.1006/geno.1996.0503 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: neuronal pentraxin I| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4884}}</ref>
== Function ==
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.<ref name="entrez"/>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS |title=Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17786–92 |year= 2000 |pmid= 10748068 |doi= 10.1074/jbc.M002254200 |doi-access= free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}} *{{cite journal |vauthors=Abad MA, Enguita M, DeGregorio-Rocasolano N, etal |title=Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain. |journal=J. Neurosci. |volume=26 |issue= 49 |pages= 12735–47 |year= 2006 |pmid= 17151277 |pmc=6674827 |doi= 10.1523/JNEUROSCI.0575-06.2006 |doi-access= free }} *{{cite journal |vauthors=Takahashi T, Strittmatter SM |title=Plexina1 autoinhibition by the plexin sema domain. |journal=Neuron |volume=29 |issue= 2 |pages= 429–39 |year= 2001 |pmid= 11239433 |doi= 10.1016/S0896-6273(01)00216-1|doi-access=free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Poulsen TT, Pedersen N, Perin MS, etal |title=Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. |journal=Lung Cancer |volume=50 |issue= 3 |pages= 329–37 |year= 2005 |pmid= 16115696 |doi= 10.1016/j.lungcan.2005.06.011 }} *{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }} {{refend}}
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