Neuropeptides B/W receptor 2

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Neuropeptides B/W receptor 2''', also known as '''NPBW2''', is a human protein encoded by the NPBWR2 gene.<ref name="entrez">{{cite web | title = Entrez Gene: NPBWR2 neuropeptides B/W receptor 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2832}}</ref>

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.<ref name="entrez" />

==See also== * Neuropeptide B/W receptor

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=O'Dowd BF, Scheideler MA, Nguyen T, etal |title=The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain |journal=Genomics |volume=28 |issue= 1 |pages= 84–91 |year= 1995 |pmid= 7590751 |doi=10.1006/geno.1995.1109 }} *{{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |doi-access= free }} *{{cite journal |vauthors=Shimomura Y, Harada M, Goto M, etal |title=Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8 |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 35826–32 |year= 2002 |pmid= 12130646 |doi= 10.1074/jbc.M205337200 |doi-access= free }} *{{cite journal |vauthors=Brezillon S, Lannoy V, Franssen JD, etal |title=Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8 |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 776–83 |year= 2003 |pmid= 12401809 |doi= 10.1074/jbc.M206396200 |doi-access= free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Tanaka H, Yoshida T, Miyamoto N, etal |title=Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 6251–6 |year= 2003 |pmid= 12719537 |doi= 10.1073/pnas.0837789100 | pmc=156358 |bibcode=2003PNAS..100.6251T |doi-access=free }} *{{cite journal |vauthors=Mazzocchi G, Rebuffat P, Ziolkowska A, etal |title=G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 6 |pages= 3466–71 |year= 2005 |pmid= 15797961 |doi= 10.1210/jc.2004-2132 |doi-access= free }} {{refend}}

==External links== *{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3003 | title = Neuropeptide B/W Receptors: NPBW2 | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-09 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303175126/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3003 | url-status = dead }}

{{DEFAULTSORT:Neuropeptides B W receptor 2}} Category:G protein-coupled receptors {{transmembranereceptor-stub}}