NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.[1][2][3]
Function
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.[3]
References
- ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018
- ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269
- ^ "Entrez Gene: NLRP7 NLR family, pyrin domain containing 7"
Further reading
- Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol.. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987
- Moglabey YB, Kircheisen R, Seoud M, etal (1999). "Genetic mapping of a maternal locus responsible for familial hydatidiform moles.". Hum. Mol. Genet.. 8 (4): 667–71. doi:10.1093/hmg/8.4.667. PMID 10072436
- Grenier JM, Wang L, Manji GA, etal (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.". FEBS Lett.. 530 (1–3): 73–8. Bibcode:2002FEBSL.530...73G. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. S2CID 25023390
- Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
- Grimwood J, Gordon LA, Olsen A, etal (2004). "The DNA sequence and biology of human chromosome 19.". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824
- Okada K, Hirota E, Mizutani Y, etal (2005). "Oncogenic role of NALP7 in testicular seminomas.". Cancer Sci.. 95 (12): 949–54. doi:10.1111/j.1349-7006.2004.tb03182.x. PMC 11158205. PMID 15596043. S2CID 13403889
- Kinoshita T, Wang Y, Hasegawa M, etal (2005). "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.". J. Biol. Chem.. 280 (23): 21720–5. doi:10.1074/jbc.M410057200. hdl:2297/2649. PMID 15817483
- Murdoch S, Djuric U, Mazhar B, etal (2006). "Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans.". Nat. Genet.. 38 (3): 300–2. doi:10.1038/ng1740. PMID 16462743. S2CID 28580007
- Bestor TH, Bourc'his D (2006). "Genetics and epigenetics of hydatidiform moles.". Nat. Genet.. 38 (3): 274–6. doi:10.1038/ng0306-274. PMID 16501554. S2CID 22981053
- Djuric U, El-Maarri O, Lamb B, etal (2007). "Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation.". Hum. Genet.. 120 (3): 390–5. doi:10.1007/s00439-006-0192-3. PMID 16874523. S2CID 10117000
- Qian J, Deveault C, Bagga R, etal (2007). "Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations.". Hum. Mutat.. 28 (7): 741. doi:10.1002/humu.9498. PMID 17579354. S2CID 43136262