{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}}
'''NLRP10''', short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP10 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.<ref name="pmid15096476">{{cite journal |vauthors=Wang Y, Hasegawa M, Imamura R, etal |title=PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1 |journal=Int. Immunol. |volume=16 |issue=6 |pages=777–86 |date=June 2004 |pmid=15096476 |doi=10.1093/intimm/dxh081 |doi-access=free |hdl=2297/15871 |hdl-access=free }}</ref><ref name="pmid20393137">{{cite journal |vauthors=Imamura R, Wang Y, Kinoshita T, etal |title=Anti-inflammatory activity of PYNOD and its mechanism in humans and mice |journal=J. Immunol. |volume=184 |issue=10 |pages=5874–84 |date=May 2010 |pmid=20393137 |doi=10.4049/jimmunol.0900779 |doi-access=free }}</ref>
==References== {{Reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Wang Y, Hasegawa M, Imamura R, etal |title=PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. |journal=Int. Immunol. |volume=16 |issue= 6 |pages= 777–86 |year= 2004 |pmid= 15096476 |doi= 10.1093/intimm/dxh081 |doi-access= free |hdl= 2297/15871 |hdl-access= free }} *{{cite journal |vauthors=Kinoshita T, Wang Y, Hasegawa M, etal |title=PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21720–5 |year= 2005 |pmid= 15817483 |doi= 10.1074/jbc.M410057200 |doi-access= free |hdl= 2297/2649 |hdl-access= free }} *{{cite journal |vauthors=Zheng D, Mohapatra G, Kern L, etal |title=Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation |journal=Nat. Immunology |volume=24 |issue= 4 |pages= 585–594 |year= 2023 |pmid= 36941399 |doi= 10.1038/s41590-023-01450-z |s2cid=257639248 }} *{{cite journal |vauthors=Inohara N, Nuñez G |title=NODs: intracellular proteins involved in inflammation and apoptosis. |journal=Nat. Rev. Immunol. |volume=3 |issue= 5 |pages= 371–82 |year= 2003 |pmid= 12766759 |doi= 10.1038/nri1086 |s2cid=8088987 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Tschopp J, Martinon F, Burns K |title=NALPs: a novel protein family involved in inflammation. |journal=Nat. Rev. Mol. Cell Biol. |volume=4 |issue= 2 |pages= 95–104 |year= 2003 |pmid= 12563287 |doi= 10.1038/nrm1019 |s2cid=31417018 }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}} *{{cite journal |vauthors=Ha HJ, Kim DS, Hahn Y |title=A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence. |journal=Biochem. Genet. |volume=47 |issue= 9–10 |pages= 665–70 |year= 2009 |pmid= 19544093 |doi= 10.1007/s10528-009-9262-2 |s2cid=31002187 }} *{{cite journal |vauthors=Ha HJ, Kim DS, Hahn Y |title=A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence. |journal=Biochem. Genet. |volume=47 |issue= 9–10 |pages= 665–70 |year= 2009 |pmid= 19544093 |doi= 10.1007/s10528-009-9262-2 |s2cid=31002187 }} {{refend}} {{NOD-like receptors}}
Category:LRR proteins Category:NOD-like receptors Category:Genes on human chromosome 11
{{Transmembranereceptor-stub}}