NLGN3

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Neuroligin-3''' is a protein that in humans is encoded by the ''NLGN3'' gene.<ref name="pmid10767552">{{cite journal | vauthors = Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI | title = The structure and expression of the human neuroligin-3 gene | journal = Gene | volume = 246 | issue = 1–2 | pages = 303–10 |date=May 2000 | pmid = 10767552 | doi =10.1016/S0378-1119(00)00049-4 }}</ref><ref name="pmid10819331">{{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 2 | pages = 143–50 |date=Sep 2000 | pmid = 10819331 | doi =10.1093/dnares/7.2.143 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLGN3 neuroligin 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54413}}</ref>

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism spectrum disorders (ASDs).<ref>{{cite journal |last1=Uchigashima |first1=Motokazu |last2=Cheung |first2=Amy |last3=Futai |first3=Kensuke |date=October 2021 |title=Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction |journal= Frontiers in Molecular Neuroscience|volume=6 |issue=14 |article-number=749164 |doi=10.3389/fnmol.2021.749164 |doi-access=free |pmc=8526735 |pmid=34690695 }}</ref><ref>{{cite journal |last1=Qin |first1=Liming |last2=Liu |first2=Zhili |last3=Guo |first3=Sile |last4=Han |first4=Ying |last5=Wang |first5=Xiankun |last6=Ren |first6=Wen |last7=Chen |first7=Jiewen |last8=Zhen |first8=Hefu |last9=Nie |first9=Chao |last10=Xing |first10=Ke-Ke |last11=Chen |first11=Tao |last12=Südhof |first12=Thomas C |last13=Sun |first13=Yuzhe |last14=Zhang |first14=Bo |display-authors=5 |date=January 2025 |title=Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number |journal=Molecular Psychiatry |volume=30 |issue=1 |pages=84–96 |doi=10.1038/s41380-024-02659-6 |pmc=11649564 |pmid=39003414 }}</ref> Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: NLGN3 neuroligin 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54413}}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Missler M, Fernandez-Chacon R, Südhof TC |title=The making of neurexins |journal=J. Neurochem. |volume=71 |issue= 4 |pages= 1339–47 |year= 1998 |pmid= 9751164 |doi=10.1046/j.1471-4159.1998.71041339.x |doi-access=free }} *{{cite journal | vauthors=Cantallops I, Cline HT |title=Synapse formation: if it looks like a duck and quacks like a duck ... |journal=Curr. Biol. |volume=10 |issue= 17 |pages= R620–3 |year= 2000 |pmid= 10996085 |doi=10.1016/S0960-9822(00)00663-1 |doi-access=free }} *{{cite journal | vauthors=Ichtchenko K, Nguyen T, Südhof TC |title=Structures, alternative splicing, and neurexin binding of multiple neuroligins |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2676–82 |year= 1996 |pmid= 8576240 |doi=10.1074/jbc.271.5.2676 |doi-access=free }} *{{cite journal |vauthors=Irie M, Hata Y, Takeuchi M, etal |title=Binding of neuroligins to PSD-95 |journal=Science |volume=277 |issue= 5331 |pages= 1511–5 |year= 1997 |pmid= 9278515 |doi=10.1126/science.277.5331.1511 }} *{{cite journal | vauthors=Nguyen T, Südhof TC |title=Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 26032–9 |year= 1997 |pmid= 9325340 |doi=10.1074/jbc.272.41.26032 |doi-access=free }} *{{cite journal | vauthors=Gilbert M, Smith J, Roskams AJ, Auld VJ |title=Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia |journal=Glia |volume=34 |issue= 3 |pages= 151–64 |year= 2001 |pmid= 11329178 |doi=10.1002/glia.1050 |s2cid=19247385 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Jamain S, Quach H, Betancur C, etal |title=Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 27–9 |year= 2003 |pmid= 12669065 |doi= 10.1038/ng1136 | pmc=1925054 }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |bibcode=2004NaGen..36...40O |doi-access= free }} *{{cite journal |vauthors=Vincent JB, Kolozsvari D, Roberts WS, etal |title=Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=129 |issue= 1 |pages= 82–4 |year= 2005 |pmid= 15274046 |doi= 10.1002/ajmg.b.30069 |s2cid=24799609 |doi-access=free }} *{{cite journal |vauthors=Gauthier J, Bonnel A, St-Onge J, etal |title=NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=132 |issue= 1 |pages= 74–5 |year= 2005 |pmid= 15389766 |doi= 10.1002/ajmg.b.30066 |s2cid=43148256 }} *{{cite journal |vauthors=Yan J, Oliveira G, Coutinho A, etal |title=Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients |journal=Mol. Psychiatry |volume=10 |issue= 4 |pages= 329–32 |year= 2005 |pmid= 15622415 |doi= 10.1038/sj.mp.4001629 |hdl=10400.18/346 |s2cid=17530049 |hdl-access=free }} *{{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |doi-access= free }} *{{cite journal |vauthors=Blasi F, Bacchelli E, Pesaresi G, etal |title=Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 3 |pages= 220–1 |year= 2006 |pmid= 16508939 |doi= 10.1002/ajmg.b.30287 |s2cid=42297317 }} *{{cite journal |vauthors=Talebizadeh Z, Lam DY, Theodoro MF, etal |title=Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism |journal=J. Med. Genet. |volume=43 |issue= 5 |pages= e21 |year= 2006 |pmid= 16648374 |doi= 10.1136/jmg.2005.036897 | pmc=2564526 }} *{{cite journal |vauthors=Yamakawa H, Oyama S, Mitsuhashi H, etal |title=Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 1 |pages= 41–6 |year= 2007 |pmid= 17292328 |doi= 10.1016/j.bbrc.2007.01.127 |bibcode=2007BBRC..355...41Y }} {{refend}}