NCR2 — Mediated Wiki

{{Short description|Mammalian protein found in Homo sapiens}} {{Infobox_gene}} '''Natural cytotoxicity triggering receptor 2''' is a protein that in humans is encoded by the ''NCR2'' gene.<ref name="pmid10049942">{{cite journal | vauthors = Cantoni C, Bottino C, Vitale M, Pessino A, Augugliaro R, Malaspina A, Parolini S, Moretta L, Moretta A, Biassoni R | title = NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily | journal = J Exp Med | volume = 189 | issue = 5 | pages = 787–96 |date=Jun 1999 | pmid = 10049942 | pmc = 2192947 | doi =10.1084/jem.189.5.787 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCR2 natural cytotoxicity triggering receptor 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9436}}</ref> NCR2 has also been designated as '''CD336''' (cluster of differentiation 336), '''NKp44, NKP44; NK-p44, LY95''', and '''dJ149M18.1'''.<ref>{{Cite web | url=https://www.ncbi.nlm.nih.gov/gene/9436 |title = NCR2 natural cytotoxicity triggering receptor 2 [Homo sapiens (human)] - Gene - NCBI}}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Hershkovitz O, Jivov S, Bloushtain N, etal |title=Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44. |journal=Biochemistry |volume=46 |issue= 25 |pages= 7426–36 |year= 2007 |pmid= 17536787 |doi= 10.1021/bi7000455 }} *{{cite journal | vauthors=Forte P, Lilienfeld BG, Baumann BC, Seebach JD |title=Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D. |journal=J. Immunol. |volume=175 |issue= 8 |pages= 5463–70 |year= 2005 |pmid= 16210654 |doi= 10.4049/jimmunol.175.8.5463|doi-access=free }} *{{cite journal | vauthors=Fuchs A, Cella M, Kondo T, Colonna M |title=Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. |journal=Blood |volume=106 |issue= 6 |pages= 2076–82 |year= 2005 |pmid= 15941912 |doi= 10.1182/blood-2004-12-4802 |doi-access= free }} *{{cite journal |vauthors=Poggi A, Massaro AM, Negrini S, etal |title=Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors. |journal=J. Immunol. |volume=174 |issue= 5 |pages= 2653–60 |year= 2005 |pmid= 15728472 |doi= 10.4049/jimmunol.174.5.2653|doi-access=free }} *{{cite journal |vauthors=Nowbakht P, Ionescu MC, Rohner A, etal |title=Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. |journal=Blood |volume=105 |issue= 9 |pages= 3615–22 |year= 2005 |pmid= 15657183 |doi= 10.1182/blood-2004-07-2585 |doi-access= free }} *{{cite journal | vauthors=Campbell KS, Yusa S, Kikuchi-Maki A, Catina TL |title=NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence. |journal=J. Immunol. |volume=172 |issue= 2 |pages= 899–906 |year= 2004 |pmid= 14707061 |doi= 10.4049/jimmunol.172.2.899|doi-access=free }} *{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |doi-access=free }} *{{cite journal |vauthors=Cantoni C, Ponassi M, Biassoni R, etal |title=The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity. |journal=Structure |volume=11 |issue= 6 |pages= 725–34 |year= 2004 |pmid= 12791260 |doi=10.1016/S0969-2126(03)00095-9 |doi-access=free }} *{{cite journal |vauthors=Augugliaro R, Parolini S, Castriconi R, etal |title=Selective cross-talk among natural cytotoxicity receptors in human natural killer cells. |journal=Eur. J. Immunol. |volume=33 |issue= 5 |pages= 1235–41 |year= 2003 |pmid= 12731048 |doi= 10.1002/eji.200323896 |s2cid=10724743 |doi-access=free }} *{{cite journal |vauthors=Allcock RJ, Barrow AD, Forbes S, etal |title=The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. |journal=Eur. J. Immunol. |volume=33 |issue= 2 |pages= 567–77 |year= 2003 |pmid= 12645956 |doi= 10.1002/immu.200310033 |s2cid=27147251 |doi-access=free }} *{{cite journal |vauthors=Cantoni C, Ponassi M, Biassoni R, etal |title=Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44. |journal=Acta Crystallogr. D |volume=58 |issue= Pt 10 Pt 2 |pages= 1843–5 |year= 2003 |pmid= 12351833 |doi=10.1107/S0907444902012325 }} {{refend}}

==External links== * {{MeshName|NCR2+protein,+human}} * [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/O95944 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Natural cytotoxicity triggering receptor 2 (NCR2)

{{DEFAULTSORT:Ncr2}} Category:Clusters of differentiation Category:Human proteins