Neurogenin-2

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{Infobox_gene}} '''Neurogenin-2''' is a protein that in humans is encoded by the ''NEUROG2'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: neurogenin 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=63973}}</ref>

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.<ref name="pmid18690213">{{cite journal | vauthors = Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F | title = Neurogenin 2 controls cortical neuron migration through regulation of Rnd2 | journal = Nature | volume = 455 | issue = 7209 | pages = 114–118 | date = September 2008 | pmid = 18690213 | doi = 10.1038/nature07198 | s2cid = 2813030 | bibcode = 2008Natur.455..114H }}</ref>

It has been found to reprogram astrocytes into glutamatergic neurons when expressed.<ref>{{cite journal | vauthors = Liu F, Zhang Y, Chen F, Yuan J, Li S, Han S, Lu D, Geng J, Rao Z, Sun L, Xu J, Shi Y, Wang X, Liu Y | title = Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord | journal = Cell Death & Disease | volume = 12 | issue = 3 | pages = 225 | date = March 2021 | pmid = 33649354 | pmc = 7921562 | doi = 10.1038/s41419-021-03498-x }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Gradwohl G, Fode C, Guillemot F | title = Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors | journal = Developmental Biology | volume = 180 | issue = 1 | pages = 227–241 | date = November 1996 | pmid = 8948587 | doi = 10.1006/dbio.1996.0297 | doi-access = free }} * {{cite journal | vauthors = Simmons AD, Horton S, Abney AL, Johnson JE | title = Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers | journal = Developmental Biology | volume = 229 | issue = 2 | pages = 327–339 | date = January 2001 | pmid = 11203697 | doi = 10.1006/dbio.2000.9984 | doi-access = free }} * {{cite journal | vauthors = Kumar M, Bagchi B, Gupta SK, Meena AS, Gressens P, Mani S | title = Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells | journal = Stem Cells and Development | volume = 16 | issue = 4 | pages = 667–681 | date = August 2007 | pmid = 17784840 | doi = 10.1089/scd.2006.0115 }} * {{cite journal | vauthors = Deng S, Deng H, Le W, Xu H, Yang H, Deng X, Lv H, Xie W, Zhu S, Jankovic J | title = Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease | journal = Neuroscience Letters | volume = 468 | issue = 3 | pages = 195–197 | date = January 2010 | pmid = 19879328 | doi = 10.1016/j.neulet.2009.10.078 | s2cid = 27698762 }} * {{cite journal | vauthors = Park CH, Kang JS, Yoon EH, Shim JW, Suh-Kim H, Lee SH | title = Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro | journal = FEBS Letters | volume = 582 | issue = 5 | pages = 537–542 | date = March 2008 | pmid = 18242186 | doi = 10.1016/j.febslet.2008.01.018 | s2cid = 33390799 | doi-access = | bibcode = 2008FEBSL.582..537P }} * {{cite journal | vauthors = Fode C, Gradwohl G, Morin X, Dierich A, LeMeur M, Goridis C, Guillemot F | title = The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons | journal = Neuron | volume = 20 | issue = 3 | pages = 483–494 | date = March 1998 | pmid = 9539123 | doi = 10.1016/S0896-6273(00)80989-7 | s2cid = 16790307 | doi-access = free }} {{refend}}

Category:Human proteins