NELL1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Protein kinase C-binding protein NELL1''' also known as '''NEL-like protein 1''' (NELL1) or '''Nel-related protein 1''' (NRP1) is a protein that in humans is encoded by the ''NELL1'' gene.<ref name="pmid8975702">{{cite journal | vauthors = Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, Kanemoto N, Nakamura Y, Hirai Y, Maekawa H, Takahashi E | title = Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats | journal = Genomics | volume = 38 | issue = 3 | pages = 273–6 |date=Mar 1997 | pmid = 8975702 | doi =10.1006/geno.1996.0628 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NELL1 NEL-like 1 (chicken)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4745}}</ref><ref name="medicalxpress">{{cite web | title = Study reveals bone-building protein's impact on bone stem cells| url = http://medicalxpress.com/news/2015-06-reveals-bone-building-protein-impact-bone.html}}</ref>

== Function ==

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.<ref name="entrez"/>

Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.<ref name="medicalxpress"/>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Auffray C, Behar G, Bois F, etal |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 }} *{{cite journal |vauthors=Ting K, Vastardis H, Mulliken JB, etal |title=Human NELL-1 expressed in unilateral coronal synostosis. |journal=J. Bone Miner. Res. |volume=14 |issue= 1 |pages= 80–9 |year= 1999 |pmid= 9893069 |doi=10.1359/jbmr.1999.14.1.80 |s2cid=25664089 |doi-access=free }} *{{cite journal | vauthors=Luce MJ, Burrows PD |title=The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage. |journal=Gene |volume=231 |issue= 1–2 |pages= 121–6 |year= 1999 |pmid= 10231576 |doi=10.1016/S0378-1119(99)00093-1 }} *{{cite journal |vauthors=Kuroda S, Oyasu M, Kawakami M, etal |title=Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2 |journal=Biochem. Biophys. Res. Commun. |volume=265 |issue= 1 |pages= 79–86 |year= 1999 |pmid= 10548494 |doi= 10.1006/bbrc.1999.1638 }} *{{cite journal |vauthors=Maeda K, Matsuhashi S, Tabuchi K, etal |title=Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors |journal=Neurol. Med. Chir. (Tokyo) |volume=41 |issue= 12 |pages= 582–8; discussion 589 |year= 2002 |pmid= 11803583 |doi=10.2176/nmc.41.582 |doi-access=free }} *{{cite journal |vauthors=Zhang X, Kuroda S, Carpenter D, etal |title=Craniosynostosis in transgenic mice overexpressing Nell-1 |journal=J. Clin. Invest. |volume=110 |issue= 6 |pages= 861–70 |year= 2002 |pmid= 12235118 |doi=10.1172/JCI15375 | pmc=151127 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Okamoto K, Matsuzaka Y, Yoshikawa Y, etal |title=Identification of NAD+-dependent isocitrate dehydrogenase 3 gamma-like (IDH3GL) gene and its genetic polymorphisms |journal=Gene |volume=323 |pages= 141–8 |year= 2004 |pmid= 14659887 |doi=10.1016/j.gene.2003.09.014 }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Tsutsumi S, Kamata N, Vokes TJ, etal |title=The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD) |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1255–61 |year= 2004 |pmid= 15124103 |doi= 10.1086/421527 | pmc=1182089 }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |doi-access=free }} *{{cite journal |vauthors=Truong T, Zhang X, Pathmanathan D, etal |title=Craniosynostosis-associated gene nell-1 is regulated by runx2 |journal=J. Bone Miner. Res. |volume=22 |issue= 1 |pages= 7–18 |year= 2007 |pmid= 17042739 |doi= 10.1359/jbmr.061012 |s2cid=24485075 |doi-access=free }} *{{cite journal |vauthors=Jin Z, Mori Y, Yang J, etal |title=Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma |journal=Oncogene |volume=26 |issue= 43 |pages= 6332–40 |year= 2007 |pmid= 17452981 |doi= 10.1038/sj.onc.1210461 |doi-access= free }} {{refend}}

Category:Human proteins

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