NAV2

{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}}

'''Neuron navigator 2''' is a protein that in humans is encoded by the ''NAV2'' gene.<ref name="pmid12079279">{{cite journal | vauthors = Maes T, Barcelo A, Buesa C | title = Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans | journal = Genomics | volume = 80 | issue = 1 | pages = 21–30 |date=Jun 2002 | pmid = 12079279 | doi =10.1006/geno.2002.6799 }}</ref><ref name="pmid12062803">{{cite journal | vauthors = Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A | title = Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms | journal = Gene | volume = 290 | issue = 1–2 | pages = 73–94 |date=Jun 2002 | pmid = 12062803 | doi =10.1016/S0378-1119(02)00567-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NAV2 neuron navigator 2|url=https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=89797}}</ref> The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. NAV2 is an atRA-responsive gene.<ref name="entrez"/>

The neuron navigator is also theorized to play a role in cellular growth and migration.<ref>{{Cite web |title=NAV2 neuron navigator 2 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=89797 |access-date=2022-05-05 |website=www.ncbi.nlm.nih.gov}}</ref> In addition, different isoforms have been discovered for this gene. Connections have been drawn to Nav2 having an association with human neurocognitive disorders Alzheimer's disease and age-related phenotypes. It has been discussed that future studies of Nav2 could provide crucial information in understanding the pathophysiology of the disease and its related phenotypes.<ref>{{Citation |last1=Xu |first1=Chun |title=Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease |date=2020-01-01 |url=https://www.sciencedirect.com/science/article/pii/B9780128158685000013 |work=Genetics, Neurology, Behavior, and Diet in Dementia |pages=3–24 |editor-last=Martin |editor-first=Colin R. |publisher=Academic Press |language=en |isbn=978-0-12-815868-5 |access-date=2022-05-05 |last2=Su |first2=Brenda Bin |last3=Lozano |first3=Stephanie |last4=Wang |first4=Kesheng |editor2-last=Preedy |editor2-first=Victor R.}}</ref>

== NAV2 association == The NAV2 gene, which is extensively expressed in the brain and is important to nervous system development, may play a role in Alzheimer's disease.<ref name="Alzheimer 2017"/> Alzheimer's disease is a chronic neurological illness whose prevalence rises rapidly as people reach the age of 65. According to reports, Alzheimer's disease is one of the top ten main causes of death in the United States. There are 50 introns and 38 exons in the neuron navigator 2 (NAV2) gene.<ref name="Alzheimer 2017">{{Cite journal |last1=Wang |first1=Ke-Sheng |last2=Liu |first2=Ying |last3=Xu |first3=Chun |last4=Liu |first4=Xuefeng |last5=Luo |first5=Xingguang |date=2017-09-15 |title=Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease |journal=Journal of Neuroimmunology |volume=310 |pages=60–65 |doi=10.1016/j.jneuroim.2017.06.010 |issn=0165-5728 |pmc=6167010 |pmid=28778446}}</ref> The NAV2 gene was shown to be strongly expressed in the brain, as well as the kidney, liver, thyroid, mammary gland, and spinal cord (and may be involved in cell proliferation, migration, and nervous system development).<ref name="Alzheimer 2017"/> NAV2 has recently been linked to episodic memory scores in Alzheimer's patients. To date, no study has looked into the link between the NAV2 gene and the risk or AAO of Alzheimer's disease.<ref name="Alzheimer 2017"/> NAV2 may be one of the processes linking blood pressure, cardiovascular disease, and neurodegenerative disorders, according to this study. NAV2 was found to be overexpressed in human colorectal cancer in another gene expression analysis, suggesting that it could be used as a predictive biomarker as well as a possible therapeutic target for colorectal cancer. However, the conducted study may have some limitations, so more research is needed to adequately understand the purpose of NAV2.<ref name="Alzheimer 2017"/>

== References == {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |doi-access=free|ref=none }} *{{Citation |last1=Xu |first1=Chun |title=Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease |date=2020-01-01 |url=https://www.sciencedirect.com/science/article/pii/B9780128158685000013 |work=Genetics, Neurology, Behavior, and Diet in Dementia |pages=3–24 |editor-last=Martin |editor-first=Colin R. |publisher=Academic Press |language=en |isbn=978-0-12-815868-5 |access-date=2022-05-05 |last2=Su |first2=Brenda Bin |last3=Lozano |first3=Stephanie |last4=Wang |first4=Kesheng |editor2-last=Preedy |editor2-first=Victor R.|ref=none}} *{{cite journal |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |doi-access=free |ref=none}} *{{cite journal |vauthors=Nagase T, Kikuno R, Ishikawa KI, etal |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65 |doi-access=free |ref=none}} *{{cite journal |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |bibcode=2000PNAS...97.3491D |doi-access=free |ref=none}} *{{cite journal | vauthors=Merrill RA, Plum LA, Kaiser ME, Clagett-Dame M |title=A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3422–7 |year= 2002 |pmid= 11904404 |doi= 10.1073/pnas.052017399 | pmc=122539 |bibcode=2002PNAS...99.3422M |doi-access=free |ref=none}} *{{cite journal |vauthors=Ishiguro H, Shimokawa T, Tsunoda T, etal |title=Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas |journal=Oncogene |volume=21 |issue= 41 |pages= 6387–94 |year= 2002 |pmid= 12214280 |doi= 10.1038/sj.onc.1205751 |doi-access= |s2cid=20205673 |ref=none}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free |ref=none}} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free |ref=none}} *{{cite journal |vauthors=Mitin NY, Ramocki MB, Zullo AJ, etal |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353–61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 |doi-access= free |ref=none}} *{{cite journal |vauthors=Tsutsumi S, Kamata N, Vokes TJ, etal |title=The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD) |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1255–61 |year= 2004 |pmid= 15124103 |doi= 10.1086/421527 | pmc=1182089 |ref=none}} *{{cite journal |vauthors=Peeters PJ, Baker A, Goris I, etal |title=Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53 |journal=Brain Res. Dev. Brain Res. |volume=150 |issue= 2 |pages= 89–101 |year= 2004 |pmid= 15158073 |doi= 10.1016/j.devbrainres.2004.03.004 |ref=none}} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |ref=none}} *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |ref=none}} *{{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |ref=none}} *{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free |ref=none}} {{refend}}

Category:Human proteins

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