{{short description|Molecular biologist}} {{Use dmy dates|date=April 2022}}{{Infobox scientist | fields = Molecular Biology | workplaces = John Innes Centre | alma_mater = LMU Munich }} '''Myriam Charpentier''' is a molecular biologist, who specialises in cell and developmental biology at the John Innes Centre, Norwich. Charpentier studies the environmental and biological stimulus of nuclear calcium signalling in plants.
She obtained her PhD in Plant Molecular Biology from LMU Munich. Following this, Charpentier joined the John Innes Centre in 2009, and became a David Philips fellow<ref>{{cite web|url=https://bbsrc.ukri.org/skills/leadership/our-fellows/david-phillips/ |title=David Phillips fellows |accessdate=2020-03-31 |website=United Kingdom Research and Innovation}}</ref> and group leader in 2017.
Charpentier investigates what produces calcium oscillations and how calcium channels affect plant development and has published extensively on this topic.<ref>{{Cite journal|last=Charpentier|first=Myriam|date=2018-07-30|title=Calcium signals in the plant nucleus: origin and function|journal=Journal of Experimental Botany|language=en|volume=69|issue=17|pages=4165–4173|doi=10.1093/jxb/ery160|pmid=29718301|issn=0022-0957|doi-access=free}}</ref><ref>{{Cite journal|last1=Kelner|first1=Audrey|last2=Leitão|first2=Nuno|last3=Chabaud|first3=Mireille|last4=Charpentier|first4=Myriam|last5=de Carvalho-Niebel|first5=Fernanda|date=2018-02-27|title=Dual Color Sensors for Simultaneous Analysis of Calcium Signal Dynamics in the Nuclear and Cytoplasmic Compartments of Plant Cells|journal=Frontiers in Plant Science|volume=9|pages=245|doi=10.3389/fpls.2018.00245|issn=1664-462X|pmc=5835324|pmid=29535753|doi-access=free }}</ref> Nuclear calcium machinery is common to all land plants, her laboratory is exploring how this has evolved and functions across different species. Dr. Charpentier has also published on topics including the dynamic organisation of the nucleus,<ref>{{Cite journal|last1=Thorpe|first1=Stephen D.|last2=Charpentier|first2=Myriam|date=2017-01-02|title=Highlight on the dynamic organization of the nucleus|journal=Nucleus|language=en|volume=8|issue=1|pages=2–10|doi=10.1080/19491034.2016.1243634|issn=1949-1034|pmc=5287096|pmid=27715428}}</ref> and on legume symbiosis<ref>{{Cite journal|last1=Murray|first1=Jeremy D.|last2=Muni|first2=RajaSekhara Reddy Duvvuru|last3=Torres-Jerez|first3=Ivone|last4=Tang|first4=Yuhong|last5=Allen|first5=Stacy|last6=Andriankaja|first6=Megan|last7=Li|first7=Guangming|last8=Laxmi|first8=Ashverya|last9=Cheng|first9=Xiaofei|last10=Wen|first10=Jiangqi|last11=Vaughan|first11=David|date=January 2011|title=Vapyrin, a gene essential for intracellular progression of arbuscular mycorrhizal symbiosis, is also essential for infection by rhizobia in the nodule symbiosis of Medicago truncatula: VAPYRIN is required for rhizobial and mycorrhizal symbioses|journal=The Plant Journal|language=en|volume=65|issue=2|pages=244–252|doi=10.1111/j.1365-313X.2010.04415.x|pmid=21223389|doi-access=free}}</ref> and nitrogen fixation.<ref>{{Cite journal|last1=Charpentier|first1=Myriam|last2=Oldroyd|first2=Giles|date=October 2010|title=How close are we to nitrogen-fixing cereals?|journal=Current Opinion in Plant Biology|language=en|volume=13|issue=5|pages=556–564|doi=10.1016/j.pbi.2010.08.003|pmid=20817544}}</ref>
Charpentier's work with Giles Oldroyd led to the discovery of cyclic nucleotide–gated ion channel 15s (CNGS15s).<ref>{{Cite web|url=https://phys.org/news/2016-05-scientists-link-nitrogen-fixation.html|title=Scientists discover missing link in plant nitrogen fixation process|website=phys.org|language=en-us|access-date=2019-03-08}}</ref><ref>{{Cite web|url=https://www.sciencedaily.com/releases/2016/05/160526151933.htm|title=Missing link in plant nitrogen fixation process discovered|website=ScienceDaily|language=en|access-date=2019-03-08}}</ref> These proteins are key in the process to move calcium into the nucleus, an important part of the signal to the plant that nitrogen-fixing bacteria are in the soil nearby.<ref>{{Cite journal|last1=Oldroyd|first1=Giles E. D.|last2=Morris|first2=Richard J.|last3=Sanders|first3=Dale|last4=Véry|first4=Anne-Aliénor|last5=Thouin|first5=Julien|last6=Soumpourou|first6=Eleni|last7=Findlay|first7=Kim|last8=Radhakrishnan|first8=Guru V.|last9=Martins|first9=Teresa Vaz|date=2016-05-27|title=Nuclear-localized cyclic nucleotide–gated channels mediate symbiotic calcium oscillations|journal=Science|language=en|volume=352|issue=6289|pages=1102–1105|doi=10.1126/science.aae0109|issn=0036-8075|pmid=27230377|bibcode=2016Sci...352.1102C|s2cid=206646218}}</ref>
More recently, in 2019, Charpentier's group discovered that nuclear calcium signalling plays another important role in plant roots, besides symbiosis. Her team showed that calcium can be released by the nucleus of root apical meristem – the region of the growing root. Using genetic approaches, the team could modulate nuclear calcium signatures to obtain longer or shorter roots in the model organism ''Arabidopsis thaliana''.<ref>{{Cite journal|last1=Leitão|first1=Nuno|last2=Dangeville|first2=Pierre|last3=Carter|first3=Ross|last4=Charpentier|first4=Myriam|date=25 October 2019|title=Nuclear calcium signatures are associated with root development|journal=Nature Communications|language=en|volume=10|issue=1|pages=4865|doi=10.1038/s41467-019-12845-8|issn=2041-1723|pmc=6814746|pmid=31653864|bibcode=2019NatCo..10.4865L}}</ref>
== References == {{reflist}}
== External links == * [https://www.jic.ac.uk/people/myriam-charpentier/ Profile on John Innes Centre site]
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{{DEFAULTSORT:Charpentier, Myriam}} Category:Living people Category:21st-century British biologists Category:21st-century women biologists Category:Year of birth missing (living people) Category:British molecular biologists Category:LMU Munich alumni Category:Women molecular biologists Category:Place of birth missing (living people)