Mir-145

{{Short description|Non-coding RNA in the species Homo sapiens}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{Infobox gene}} {{Infobox rfam | Name = mir-145 | image = RF00675.png | width = | caption = Conserved secondary structure of mir-145 | Symbol = mir-145 | AltSymbols = | Rfam = RF00675 | miRBase_family = MIPF0000079 | RNA_type = microRNA | Tax_domain = ''Eukaryota;'' | HGNCid = | OMIM = }}

In molecular biology, '''mir-145 microRNA''' is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.<ref name="entrez">{{cite web | title = Entrez Gene: MicroRNA 145 | url = https://www.ncbi.nlm.nih.gov/gene/406937 | access-date = 2015-01-26 <!-- T13:30:41.834879-08:00 --> }}</ref>

==Targets== MicroRNAs are involved in down-regulation of a variety of target genes. Götte ''et al''. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin in breast cancer and endometriosis cells, resulting in a reduction of cell motility.<ref>{{cite journal | vauthors = Adammek M | title = MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors. | journal = Fertility and Sterility | volume = 99 | issue = 5 | pages = 1346–1355.e5 | date = 2013 | pmid = 23312222 | doi = 10.1016/j.fertnstert.2012.11.055 | doi-access = free }}</ref><ref name="Gotte_2010">{{cite journal | vauthors = Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW | title = miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness | journal = Oncogene | volume = 29 | issue = 50 | pages = 6569–6580 | date = Dec 2010 | pmid = 20818426 | doi = 10.1038/onc.2010.386 | s2cid = 11455884 }}</ref> Larsson ''et al''.<ref name="Larsson_2009">{{cite journal | vauthors = Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, Arrondel C, Gerwins P, Kurschat C, Schermer B, Benzing T, Harvey SJ, Kreuger J, Lindahl P | title = Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1 | journal = Genome Medicine | volume = 1 | issue = 11 | article-number = 108 | date = Nov 2009 | pmid = 19917099 | pmc = 2808743 | doi = 10.1186/gm108 | doi-access = free }}</ref> showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang ''et al''.<ref name="Zhang_2011" />

==Role in cancer== miR-145 is hypothesised to be a tumor suppressor.<ref name="Sachdeva_2009">{{cite journal | vauthors = Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY | title = p53 represses c-Myc through induction of the tumor suppressor miR-145 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 9 | pages = 3207–3212 | date = Mar 2009 | pmid = 19202062 | pmc = 2651330 | doi = 10.1073/pnas.0808042106 | doi-access = free | bibcode = 2009PNAS..106.3207S }}</ref> miR-145 has been shown to be down-regulated in breast cancer.<ref name="Gotte_2010" /> miR-145 is also involved in colon cancer<ref name="Zhang_2011">{{cite journal | vauthors = Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S | title = Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene | journal = Cancer | volume = 117 | issue = 1 | pages = 86–95 | date = Jan 2011 | pmid = 20737575 | pmc = 2995010 | doi = 10.1002/cncr.25522 }}</ref><ref name="Slaby_2007">{{cite journal | vauthors = Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, Nenutil R, Vyzula R | title = Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer | journal = Oncology | volume = 72 | issue = 5–6 | pages = 397–402 | year = 2007 | pmid = 18196926 | doi = 10.1159/000113489 | s2cid = 207615720 }}</ref><ref>{{Cite journal | vauthors = Mazza T, Mazzoccoli G, Fusilli C, Capocefalo D, Panza A, Biagini T, Castellana S, Gentile A, De Cata A | title = Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer | journal = Nucleic Acids Research | volume = 44 | issue = 9 | pages = 4025–4036 | date = 2016-05-19 | pmid = 27067546 | pmc = 4872111 | doi = 10.1093/nar/gkw245 | issn = 1362-4962 }}</ref> and acute myeloid leukemia.<ref name="Starczynowski_2011">{{cite journal | vauthors = Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, Kuchenbauer F, Hirst M, Tohyama K, Humphries RK, Lam WL, Marra M, Karsan A | title = Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations | journal = Blood | volume = 117 | issue = 2 | pages = 595–607 | date = Jan 2011 | pmid = 20962326 | doi = 10.1182/blood-2010-03-277012 | url = http://www.bloodjournal.org/content/117/2/595?sso-checked=true | doi-access = free }}</ref>

== References == {{reflist|30em}} {{clear}}

== Further reading == {{refbegin|33em}} * {{cite journal | vauthors = Zhang J, Guo H, Qian G, Ge S, Ji H, Hu X, Chen W | title = MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network | journal = Molecular Cancer | volume = 9 | article-number = 211 | date = Aug 2010 | pmid = 20687965 | pmc = 2924312 | doi = 10.1186/1476-4598-9-211 | doi-access = free }} * {{cite journal | vauthors = Zaman MS, Chen Y, Deng G, Shahryari V, Suh SO, Saini S, Majid S, Liu J, Khatri G, Tanaka Y, Dahiya R | title = The functional significance of microRNA-145 in prostate cancer | journal = British Journal of Cancer | volume = 103 | issue = 2 | pages = 256–264 | date = Jul 2010 | pmid = 20588276 | pmc = 2906737 | doi = 10.1038/sj.bjc.6605742 }} * {{cite journal | vauthors = Sachdeva M, Mo YY | title = miR-145-mediated suppression of cell growth, invasion and metastasis | journal = American Journal of Translational Research | volume = 2 | issue = 2 | pages = 170–180 | date = Mar 2010 | pmid = 20407606 | pmc = 2855636 }} * {{cite journal | vauthors = Kano M, Seki N, Kikkawa N, Fujimura L, Hoshino I, Akutsu Y, Chiyomaru T, Enokida H, Nakagawa M, Matsubara H | title = miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma | journal = International Journal of Cancer | volume = 127 | issue = 12 | pages = 2804–2814 | date = Dec 2010 | pmid = 21351259 | doi = 10.1002/ijc.25284 | s2cid = 25480039 | doi-access = free }} * {{cite journal | vauthors = Chiyomaru T, Enokida H, Tatarano S, Kawahara K, Uchida Y, Nishiyama K, Fujimura L, Kikkawa N, Seki N, Nakagawa M | title = miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer | journal = British Journal of Cancer | volume = 102 | issue = 5 | pages = 883–891 | date = Mar 2010 | pmid = 20160723 | pmc = 2833258 | doi = 10.1038/sj.bjc.6605570 }} * {{cite journal | vauthors = Gregersen LH, Jacobsen AB, Frankel LB, Wen J, Krogh A, Lund AH | title = MicroRNA-145 targets YES and STAT1 in colon cancer cells | journal = PLOS ONE | volume = 5 | issue = 1 | article-number = e8836 | date = Jan 2010 | pmid = 20098684 | pmc = 2809101 | doi = 10.1371/journal.pone.0008836 | editor1-last = Kudla | editor1-first = Grzegorz | doi-access = free | bibcode = 2010PLoSO...5.8836G }} * {{cite journal | vauthors = Sachdeva M, Mo YY | title = MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1 | journal = Cancer Research | volume = 70 | issue = 1 | pages = 378–387 | date = Jan 2010 | pmid = 19996288 | pmc = 2805032 | doi = 10.1158/0008-5472.CAN-09-2021 }} * {{cite journal | vauthors = Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, Arrondel C, Gerwins P, Kurschat C, Schermer B, Benzing T, Harvey SJ, Kreuger J, Lindahl P | title = Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1 | journal = Genome Medicine | volume = 1 | issue = 11 | article-number = 108 | date = Nov 2009 | pmid = 19917099 | pmc = 2808743 | doi = 10.1186/gm108 | doi-access = free }} * {{cite journal | vauthors = Ostenfeld MS, Bramsen JB, Lamy P, Villadsen SB, Fristrup N, Sørensen KD, Ulhøi B, Borre M, Kjems J, Dyrskjøt L, Orntoft TF | title = miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors | journal = Oncogene | volume = 29 | issue = 7 | pages = 1073–1084 | date = Feb 2010 | pmid = 19915607 | doi = 10.1038/onc.2009.395 | s2cid = 25309570 }} * {{cite journal | vauthors = Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, Hirst M, Hogge D, Marra M, Wells RA, Buckstein R, Lam W, Humphries RK, Karsan A | title = Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype | journal = Nature Medicine | volume = 16 | issue = 1 | pages = 49–58 | date = Jan 2010 | pmid = 19898489 | doi = 10.1038/nm.2054 | s2cid = 7987486 }} * {{cite journal | vauthors = Arndt GM, Dossey L, Cullen LM, Lai A, Druker R, Eisbacher M, Zhang C, Tran N, Fan H, Retzlaff K, Bittner A, Raponi M | title = Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer | journal = BMC Cancer | volume = 9 | article-number = 374 | date = Oct 2009 | pmid = 19843336 | pmc = 2770572 | doi = 10.1186/1471-2407-9-374 | doi-access = free }} * {{cite journal | vauthors = Zhang C | title = MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease | journal = Cell Cycle | location = Georgetown, Tex. | volume = 8 | issue = 21 | pages = 3469–3473 | date = Nov 2009 | pmid = 19829088 | pmc = 3593963 | doi = 10.4161/cc.8.21.9837 }} * {{cite journal | vauthors = Zeng L, Carter AD, Childs SJ | title = miR-145 directs intestinal maturation in zebrafish | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 42 | pages = 17793–17798 | date = Oct 2009 | pmid = 19805048 | pmc = 2764920 | doi = 10.1073/pnas.0903693106 | doi-access = free | bibcode = 2009PNAS..10617793Z }} * {{cite journal | vauthors = Spizzo R, Nicoloso MS, Lupini L, Lu Y, Fogarty J, Rossi S, Zagatti B, Fabbri M, Veronese A, Liu X, Davuluri R, Croce CM, Mills G, Negrini M, Calin GA | title = miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells | journal = Cell Death and Differentiation | volume = 17 | issue = 2 | pages = 246–254 | date = Feb 2010 | pmid = 19730444 | pmc = 3648637 | doi = 10.1038/cdd.2009.117 }} * {{cite journal | vauthors = Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN | title = MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury | journal = Genes & Development | volume = 23 | issue = 18 | pages = 2166–2178 | date = Sep 2009 | pmid = 19720868 | pmc = 2751981 | doi = 10.1101/gad.1842409 }} * {{cite journal | vauthors = Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D | title = miR-145 and miR-143 regulate smooth muscle cell fate and plasticity | journal = Nature | volume = 460 | issue = 7256 | pages = 705–710 | date = Aug 2009 | pmid = 19578358 | pmc = 2769203 | doi = 10.1038/nature08195 | bibcode = 2009Natur.460..705C }} * {{cite journal | vauthors = Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, Lu Q, Deitch EA, Huo Y, Delphin ES, Zhang C | title = MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation | journal = Circulation Research | volume = 105 | issue = 2 | pages = 158–166 | date = Jul 2009 | pmid = 19542014 | pmc = 2728297 | doi = 10.1161/CIRCRESAHA.109.197517 }} * {{cite journal | vauthors = Cho WC, Chow AS, Au JS | title = Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation | journal = European Journal of Cancer | location = Oxford, England | volume = 45 | issue = 12 | pages = 2197–2206 | date = Aug 2009 | pmid = 19493678 | doi = 10.1016/j.ejca.2009.04.039 }} * {{cite journal | vauthors = Chivukula RR, Mendell JT | title = Abate and switch: miR-145 in stem cell differentiation | journal = Cell | volume = 137 | issue = 4 | pages = 606–608 | date = May 2009 | pmid = 19450510 | doi = 10.1016/j.cell.2009.04.059 | doi-access = free }} * {{cite journal | vauthors = Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS | title = MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells | journal = Cell | volume = 137 | issue = 4 | pages = 647–658 | date = May 2009 | pmid = 19409607 | doi = 10.1016/j.cell.2009.02.038 | s2cid = 18601406 | doi-access = free }} * {{cite journal | vauthors = La Rocca G, Badin M, Shi B, Xu SQ, Deangelis T, Sepp-Lorenzinoi L, Baserga R | title = Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway | journal = Journal of Cellular Physiology | volume = 220 | issue = 2 | pages = 485–491 | date = Aug 2009 | pmid = 19391107 | doi = 10.1002/jcp.21796 | s2cid = 44343336 }} * {{cite journal | vauthors = Wang S, Bian C, Yang Z, Bo Y, Li J, Zeng L, Zhou H, Zhao RC | title = miR-145 inhibits breast cancer cell growth through RTKN | journal = International Journal of Oncology | volume = 34 | issue = 5 | pages = 1461–1466 | date = May 2009 | pmid = 19360360 | doi = 10.3892/ijo_00000275 | doi-access = free }} * {{cite journal | vauthors = Zheng L, Pu J, Qi T, Qi M, Li D, Xiang X, Huang K, Tong Q | title = miRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells | journal = Molecular Cancer Research | volume = 11 | issue = 2 | pages = 182–193 | date = Feb 2013 | pmid = 23233482 | doi = 10.1158/1541-7786.MCR-12-0534 | doi-access = free }} {{refend}}

== External links == * {{Rfam|id=RF00675|name=mir-145 microRNA precursor family}} {{miRNA precursor families}}

Category:MicroRNA Category:Tumor suppressor genes