{{infobox enzyme | Name = Meprin A | EC_number = 3.4.24.18 | CAS_number = 148938-24-3 | GO_code = 0017090 | image = | width = | caption = }} {{Pfam_box | Symbol = Meprin | Name = Meprin A | image = | width = | caption = | InterPro= IPR008294 | SMART= | PROSITE = | SCOP = | TCDB = | OPM family= | OPM protein= | Pfam= | PDB= | Membranome family= 537 }} '''Meprin A''' ({{EC number|3.4.24.18}}, ''endopeptidase-2'', ''meprin-a'', ''meprin'', ''N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase'', ''PABA-peptide hydrolase'', ''PPH'') is an enzyme that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.<ref name="pmid18783725">{{cite journal | vauthors = Sterchi EE, Stöcker W, Bond JS | title = Meprins, membrane-bound and secreted astacin metalloproteinases | journal = Molecular Aspects of Medicine | volume = 29 | issue = 5 | pages = 309–28 | date = October 2008 | pmid = 18783725 | pmc = 2650038 | doi = 10.1016/j.mam.2008.08.002 }}</ref> This metalloprotease can be associated with inflammatory responses.<ref name="Prox_2015">{{cite journal | vauthors = Prox J, Arnold P, Becker-Pauly C | title = Meprin α and meprin β: procollagen proteinases in health and disease. | journal = Matrix Biology | date = May 2015 | volume = 44 | pages = 7–13 | doi = 10.1016/j.matbio.2015.01.010 | pmid = 25617491 | doi-access = free }}</ref> It can be found in the extracellular space where it can also form complex structures by joining its monomers together.<ref name="Prox_2015" />
Meprin A is a dimer composed of the products transcribed from the following two genes:
{| |{{protein | Name = meprin A, alpha | caption = | image = | width = | HGNCid = 7015 | Symbol = MEP1A | AltSymbols = | EntrezGene = 4224 | OMIM = 600388 | RefSeq = NM_005588 | UniProt = Q16819 | PDB = | ECnumber = 3.4.24.18 | Chromosome = 6 | Arm = p | Band = 12 | LocusSupplementaryData = -p11 }} |{{protein | Name = meprin A, beta | caption = | image = | width = | HGNCid = 7020 | Symbol = MEP1B | AltSymbols = | EntrezGene = 4225 | OMIM = 600389 | RefSeq = NM_005925 | UniProt = Q16820 | PDB = | ECnumber = 3.4.24.18 | Chromosome = 18 | Arm = q | Band = 12.2-12.3 | LocusSupplementaryData = }} |}
== References == {{Reflist}}
{{Metalloendopeptidases}} {{Enzymes}} {{Portal bar|Biology|border=no}}
Category:EC 3.4.24 Category:Single-pass transmembrane proteins
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